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- W3085548914 abstract "Abstract Background Gastric cancer (GC) is the common cause of cancer-related deaths worldwide and inflammation represents the early phases in the GC. Objective To review the tumor necrosis factor (TNF)-α-308 G>A (GG, GA, and AA) in GC by meta-analysis studies for any differences in TNF-α-308 G>A gene polymorphisms. Methods Case–control studies published from 2003 to 2017 were identified by searching PubMed, EMASE, and the Internet with the English language. The analysis published on TNF-α-308 G>A polymorphism was analyzed and a limited number of articles were included in the present study. TNF-α-308 G>A from 4,157 patients and 5,185 healthy controls was evaluated. Studies were evaluated using Cochrane Q -test and publication bias was evaluated by constructing funnel plots. Results Overall, TNF-α-308 GA genotype showed significant association [ P < 0.0001, odds ratio (OR), 95% confidence interval (CI) = 0.82 (0.74–0.91)]. However, meta-analysis of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) between GC patients and controls showed nonsignificant association with GC [ P > 0.05, recessive model: OR = 1.38, 95% CI: 1.15–1.66; dominant model: OR = 1.23, 95% CI: 1.09–1.39; (G/A) vs. (G/G): OR = 1.15, 95% CI: 1.02–1.28; (A/A) vs. (G/G): OR = 1.44, 95% CI: 1.19–1.73]. Analysis stratified by ethnicity showed same results in Asian and Caucasian populations. Conclusions Results revealed nonsignificant association of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) and GC. TNF-α-308GA genotype showed significant association whereas homozygous genotype AA did not show association with GC risk." @default.
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- W3085548914 date "2020-06-01" @default.
- W3085548914 modified "2023-10-17" @default.
- W3085548914 title "A meta-analysis of tumor necrosis factor-α-308 G>A polymorphism in gastric cancer" @default.
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- W3085548914 doi "https://doi.org/10.1515/abm-2020-0014" @default.
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