FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085569899> ?p ?o ?g. }

• W3085569899 endingPage "873" @default.
• W3085569899 startingPage "873" @default.
• W3085569899 abstract "Some withanolides, particularly the family of steroidal lactones, show anticancer effects, but this is rarely reported for withanolide C (WHC)—especially anti-breast cancer effects. The subject of this study is to evaluate the ability of WHC to regulate the proliferation of breast cancer cells, using both time and concentration in treatment with WHC. In terms of ATP depletion, WHC induced more antiproliferation to three breast cancer cell lines, SKBR3, MCF7, and MDA-MB-231, than to normal breast M10 cell lines. SKBR3 and MCF7 cells showing higher sensitivity to WHC were used to explore the antiproliferation mechanism. Flow cytometric apoptosis analyses showed that subG1 phase and annexin V population were increased in breast cancer cells after WHC treatment. Western blotting showed that cleaved forms of the apoptotic proteins poly (ADP-ribose) polymerase (c-PARP) and cleaved caspase 3 (c-Cas 3) were increased in breast cancer cells. Flow cytometric oxidative stress analyses showed that WHC triggered reactive oxygen species (ROS) and mitochondrial superoxide (MitoSOX) production as well as glutathione depletion. In contrast, normal breast M10 cells showed lower levels of ROS and annexin V expression than breast cancer cells. Flow cytometric DNA damage analyses showed that WHC triggered γH2AX and 8-oxo-2′-deoxyguanosine (8-oxodG) expression in breast cancer cells. Moreover, N-acetylcysteine (NAC) pretreatment reverted oxidative stress-mediated ATP depletion, apoptosis, and DNA damage. Therefore, WHC kills breast cancer cells depending on oxidative stress-associated mechanisms." @default.
• W3085569899 created "2020-09-21" @default.
• W3085569899 creator A5005529087 @default.
• W3085569899 creator A5007119516 @default.
• W3085569899 creator A5030960192 @default.
• W3085569899 creator A5035146670 @default.
• W3085569899 creator A5040790736 @default.
• W3085569899 creator A5052414336 @default.
• W3085569899 creator A5060755845 @default.
• W3085569899 creator A5084088122 @default.
• W3085569899 date "2020-09-16" @default.
• W3085569899 modified "2023-10-14" @default.
• W3085569899 title "Withanolide C Inhibits Proliferation of Breast Cancer Cells via Oxidative Stress-Mediated Apoptosis and DNA Damage" @default.
• W3085569899 cites W1965564922 @default.
• W3085569899 cites W1972779889 @default.
• W3085569899 cites W1987092520 @default.
• W3085569899 cites W1988857580 @default.
• W3085569899 cites W1994930469 @default.
• W3085569899 cites W2011293304 @default.
• W3085569899 cites W2012879968 @default.
• W3085569899 cites W2036640994 @default.
• W3085569899 cites W2039386203 @default.
• W3085569899 cites W2041511542 @default.
• W3085569899 cites W2049660337 @default.
• W3085569899 cites W2061110648 @default.
• W3085569899 cites W2071912398 @default.
• W3085569899 cites W2084046711 @default.
• W3085569899 cites W2092118074 @default.
• W3085569899 cites W2103037071 @default.
• W3085569899 cites W2106281303 @default.
• W3085569899 cites W2107070385 @default.
• W3085569899 cites W2111573377 @default.
• W3085569899 cites W2113313289 @default.
• W3085569899 cites W2113433800 @default.
• W3085569899 cites W2149428444 @default.
• W3085569899 cites W2152802447 @default.
• W3085569899 cites W2224595412 @default.
• W3085569899 cites W2548196609 @default.
• W3085569899 cites W2728625906 @default.
• W3085569899 cites W2751023845 @default.
• W3085569899 cites W2752163938 @default.
• W3085569899 cites W2770024163 @default.
• W3085569899 cites W2782888904 @default.
• W3085569899 cites W2802794863 @default.
• W3085569899 cites W2809911985 @default.
• W3085569899 cites W2810519118 @default.
• W3085569899 cites W2877199190 @default.
• W3085569899 cites W2888734518 @default.
• W3085569899 cites W2915774090 @default.
• W3085569899 cites W2922402510 @default.
• W3085569899 cites W2948938002 @default.
• W3085569899 cites W2953948521 @default.
• W3085569899 cites W2971395209 @default.
• W3085569899 cites W2995975007 @default.
• W3085569899 cites W3037960840 @default.
• W3085569899 doi "https://doi.org/10.3390/antiox9090873" @default.
• W3085569899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7555407" @default.
• W3085569899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32947878" @default.
• W3085569899 hasPublicationYear "2020" @default.
• W3085569899 type Work @default.
• W3085569899 sameAs 3085569899 @default.
• W3085569899 citedByCount "13" @default.
• W3085569899 countsByYear W30855698992021 @default.
• W3085569899 countsByYear W30855698992022 @default.
• W3085569899 countsByYear W30855698992023 @default.
• W3085569899 crossrefType "journal-article" @default.
• W3085569899 hasAuthorship W3085569899A5005529087 @default.
• W3085569899 hasAuthorship W3085569899A5007119516 @default.
• W3085569899 hasAuthorship W3085569899A5030960192 @default.
• W3085569899 hasAuthorship W3085569899A5035146670 @default.
• W3085569899 hasAuthorship W3085569899A5040790736 @default.
• W3085569899 hasAuthorship W3085569899A5052414336 @default.
• W3085569899 hasAuthorship W3085569899A5060755845 @default.
• W3085569899 hasAuthorship W3085569899A5084088122 @default.
• W3085569899 hasBestOaLocation W30855698991 @default.
• W3085569899 hasConcept C121608353 @default.
• W3085569899 hasConcept C126322002 @default.
• W3085569899 hasConcept C143425029 @default.
• W3085569899 hasConcept C182979987 @default.
• W3085569899 hasConcept C185592680 @default.
• W3085569899 hasConcept C190283241 @default.
• W3085569899 hasConcept C191560914 @default.
• W3085569899 hasConcept C2776151105 @default.
• W3085569899 hasConcept C2994423619 @default.
• W3085569899 hasConcept C48349386 @default.
• W3085569899 hasConcept C502942594 @default.
• W3085569899 hasConcept C530470458 @default.
• W3085569899 hasConcept C552990157 @default.
• W3085569899 hasConcept C55493867 @default.
• W3085569899 hasConcept C71924100 @default.
• W3085569899 hasConcept C75217442 @default.
• W3085569899 hasConcept C82381507 @default.
• W3085569899 hasConcept C86803240 @default.
• W3085569899 hasConcept C88634738 @default.
• W3085569899 hasConcept C96232424 @default.
• W3085569899 hasConceptScore W3085569899C121608353 @default.
• W3085569899 hasConceptScore W3085569899C126322002 @default.
• W3085569899 hasConceptScore W3085569899C143425029 @default.

• next