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• W3085587511 abstract "MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could improve the progression of breast cancer. Our results indicate that up-regulation of miR-548 significantly inhibits cell proliferation, migration andinvasion, and induces apoptosis in breast cancer cells. Further studies showed that miR-548 could specifically inhibit E2F3 expression. Moreover, rescue test showed that up-regulation of E2F2 could reverse the effect of miR-548 on proliferation, migration, invasion and apoptosis of breast cancer cells. In general, miR-548 could improve the progression of breast cancer. By targeting E2F2, which may make a potential target for the treatment of breast cancer." @default.
• W3085587511 created "2020-09-21" @default.
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• W3085587511 date "2020-09-09" @default.
• W3085587511 modified "2023-09-27" @default.
• W3085587511 title "MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3" @default.
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• W3085587511 doi "https://doi.org/10.1007/s10616-020-00418-3" @default.
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