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- W3085620154 abstract "There are hundreds of EGFR mutations reported in lung cancer, but not all EGFR mutations are created equal.1 Most EGFR mutations are deletions in exon 19 (del19) and substitution of arginine for leucine at codon 858 of exon 21 (L858R). EGFR del19 and L858R are often referred to as the common (or classic) EGFR mutations, accounting for up to 80% to 85% of all EGFR mutations.1 Currently available EGFR tyrosine kinase inhibitors (TKIs), including first-generation gefitinib and erlotinib, second-generation afatinib and dacomitinib, and third-generation osimertinib have been proven to control lung cancer with EGFR del19 or L858R mutations in phase 3 trials." @default.
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- W3085620154 date "2020-09-01" @default.
- W3085620154 modified "2023-09-30" @default.
- W3085620154 title "Not All EGFR Exon 20 Insertions Are Created Equal" @default.
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- W3085620154 doi "https://doi.org/10.1016/j.jtocrr.2020.100069" @default.
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