FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085640399> ?p ?o ?g. }

• W3085640399 endingPage "514" @default.
• W3085640399 startingPage "503" @default.
• W3085640399 abstract "Background: Renal cell carcinoma (RCC) is one of the most common and malignant tumors in the urinary system. The aim of this research was to investigate the mechanism and clinical significance of miR-4461 in the RCC progression. Materials and Methods: Twenty-eight (28) paired RCC tissue samples and adjacent nontumor tissue samples, as well as RCC cell lines were used to measure the expression of miR-4461 and protein phosphatase 1 regulatory subunit 3C (PPP1R3C) transcript by real-time quantitative PCR. The target relationship between miR-4461 and PPP1R3C was predicted by TargetScan and further verified by dual-luciferase reporter gene assay and RNA pull-down assay. Cell Counting Kit-8 (CCK-8) assay and BrdU ELISA assay were performed to measure RCC cell viability and proliferation. In addition, caspase-3 activity assay and cell adhesion assay were implemented to measure RCC cell apoptosis and adhesion. Results: MiR-4461 was lowly expressed both in RCC tissues and cells, while upregulated PPP1R3C was tested in RCC tissues and cells. In addition, miR-4461 was validated to directly target PPP1R3C, thereby negatively regulating PPP1R3C. Particularly, miR-4461 exerted a clear inhibitory effect on the malignant phenotypes of RCC cells by binding and inhibiting PPP1R3C. Conclusion: MiR-4461, which served as a tumor suppressor, inhibited RCC progression by targeting and downregulating PPP1R3C." @default.
• W3085640399 created "2020-09-21" @default.
• W3085640399 creator A5019681478 @default.
• W3085640399 creator A5029468966 @default.
• W3085640399 creator A5069842224 @default.
• W3085640399 creator A5077498694 @default.
• W3085640399 date "2022-08-01" @default.
• W3085640399 modified "2023-10-05" @default.
• W3085640399 title "MiR-4461 Inhibits Tumorigenesis of Renal Cell Carcinoma by Targeting PPP1R3C" @default.
• W3085640399 cites W1987318711 @default.
• W3085640399 cites W1987977871 @default.
• W3085640399 cites W2035396608 @default.
• W3085640399 cites W2037075168 @default.
• W3085640399 cites W2038295374 @default.
• W3085640399 cites W2142878546 @default.
• W3085640399 cites W2163169932 @default.
• W3085640399 cites W2193001123 @default.
• W3085640399 cites W2242872397 @default.
• W3085640399 cites W2264436887 @default.
• W3085640399 cites W2273595698 @default.
• W3085640399 cites W2404501375 @default.
• W3085640399 cites W2519942994 @default.
• W3085640399 cites W2529526566 @default.
• W3085640399 cites W2553644640 @default.
• W3085640399 cites W2557897759 @default.
• W3085640399 cites W2559771401 @default.
• W3085640399 cites W2571217738 @default.
• W3085640399 cites W2605205463 @default.
• W3085640399 cites W2615072496 @default.
• W3085640399 cites W2616070469 @default.
• W3085640399 cites W2618956957 @default.
• W3085640399 cites W2743246611 @default.
• W3085640399 cites W2767201918 @default.
• W3085640399 cites W2796748396 @default.
• W3085640399 cites W2799468412 @default.
• W3085640399 cites W2801994090 @default.
• W3085640399 cites W2811193802 @default.
• W3085640399 cites W2886245314 @default.
• W3085640399 cites W2890782403 @default.
• W3085640399 cites W2901427501 @default.
• W3085640399 cites W2947550553 @default.
• W3085640399 cites W2949175413 @default.
• W3085640399 cites W2952777458 @default.
• W3085640399 cites W2976596173 @default.
• W3085640399 cites W2982105993 @default.
• W3085640399 cites W2997675748 @default.
• W3085640399 cites W2999853926 @default.
• W3085640399 cites W3000120095 @default.
• W3085640399 cites W3004681686 @default.
• W3085640399 cites W3006335555 @default.
• W3085640399 cites W4210983935 @default.
• W3085640399 doi "https://doi.org/10.1089/cbr.2020.3846" @default.
• W3085640399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32915648" @default.
• W3085640399 hasPublicationYear "2022" @default.
• W3085640399 type Work @default.
• W3085640399 sameAs 3085640399 @default.
• W3085640399 citedByCount "5" @default.
• W3085640399 countsByYear W30856403992021 @default.
• W3085640399 countsByYear W30856403992022 @default.
• W3085640399 countsByYear W30856403992023 @default.
• W3085640399 crossrefType "journal-article" @default.
• W3085640399 hasAuthorship W3085640399A5019681478 @default.
• W3085640399 hasAuthorship W3085640399A5029468966 @default.
• W3085640399 hasAuthorship W3085640399A5069842224 @default.
• W3085640399 hasAuthorship W3085640399A5077498694 @default.
• W3085640399 hasConcept C121608353 @default.
• W3085640399 hasConcept C142724271 @default.
• W3085640399 hasConcept C1491633281 @default.
• W3085640399 hasConcept C153911025 @default.
• W3085640399 hasConcept C2777472916 @default.
• W3085640399 hasConcept C502942594 @default.
• W3085640399 hasConcept C53227056 @default.
• W3085640399 hasConcept C54355233 @default.
• W3085640399 hasConcept C555283112 @default.
• W3085640399 hasConcept C62112901 @default.
• W3085640399 hasConcept C71924100 @default.
• W3085640399 hasConcept C81885089 @default.
• W3085640399 hasConcept C85789140 @default.
• W3085640399 hasConcept C86803240 @default.
• W3085640399 hasConceptScore W3085640399C121608353 @default.
• W3085640399 hasConceptScore W3085640399C142724271 @default.
• W3085640399 hasConceptScore W3085640399C1491633281 @default.
• W3085640399 hasConceptScore W3085640399C153911025 @default.
• W3085640399 hasConceptScore W3085640399C2777472916 @default.
• W3085640399 hasConceptScore W3085640399C502942594 @default.
• W3085640399 hasConceptScore W3085640399C53227056 @default.
• W3085640399 hasConceptScore W3085640399C54355233 @default.
• W3085640399 hasConceptScore W3085640399C555283112 @default.
• W3085640399 hasConceptScore W3085640399C62112901 @default.
• W3085640399 hasConceptScore W3085640399C71924100 @default.
• W3085640399 hasConceptScore W3085640399C81885089 @default.
• W3085640399 hasConceptScore W3085640399C85789140 @default.
• W3085640399 hasConceptScore W3085640399C86803240 @default.
• W3085640399 hasIssue "6" @default.
• W3085640399 hasLocation W30856403991 @default.
• W3085640399 hasLocation W30856403992 @default.
• W3085640399 hasOpenAccess W3085640399 @default.
• W3085640399 hasPrimaryLocation W30856403991 @default.

• next