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• W3085646968 endingPage "112830" @default.
• W3085646968 startingPage "112830" @default.
• W3085646968 abstract "Podophyllotoxins and epipodophyllotoxins, possess excellent activity against both drug-sensitive and drug-resistant even multidrug-resistant cancer cells via inhibition of tubulin polymerization. Several podophyllotoxin/epipodophyllotoxin derivatives such as etoposide and teniposide have already been applied for cancer therapy, revealing their potential as putative anticancer drugs. Hybridization of podophyllotoxin/epipodophyllotoxin moiety with other anticancer pharmacophores is a promising strategy to develop novel drug candidates so as to overcome drug resistance and improve the specificity, and numerous of podophyllotoxin/epipodophyllotoxin hybrids exhibit excellent in vitro antiproliferative and in vivo anticancer potency. This review emphasizes the recent development of podophyllotoxin/epipodophyllotoxin hybrids with potential application for cancer therapy covering articles published between 2010 and 2020. The mechanisms of action, the critical aspects of design as well as structure-activity relationships were also summarized. This review covers the recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship which developed in recent 10 years to set up the direction for the design and development of podophyllotoxin/epipodophyllotoxin hybrids with high efficiency and low toxicity. • The recent advances of podophyllotoxin/epipodophyllotoxin hybrids as potential anticancer agents were summarized. • The structure-activity relationship was discussed. • The mechanism of action was included." @default.
• W3085646968 created "2020-09-21" @default.
• W3085646968 creator A5017904678 @default.
• W3085646968 creator A5037699390 @default.
• W3085646968 creator A5049078993 @default.
• W3085646968 creator A5054937803 @default.
• W3085646968 creator A5061365614 @default.
• W3085646968 creator A5082016315 @default.
• W3085646968 date "2020-12-01" @default.
• W3085646968 modified "2023-10-02" @default.
• W3085646968 title "Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010–2020)" @default.
• W3085646968 cites W1607298635 @default.
• W3085646968 cites W1833111122 @default.
• W3085646968 cites W1899051841 @default.
• W3085646968 cites W1911848826 @default.
• W3085646968 cites W1965022269 @default.
• W3085646968 cites W1969851932 @default.
• W3085646968 cites W1971106530 @default.
• W3085646968 cites W1971529502 @default.
• W3085646968 cites W1978068626 @default.
• W3085646968 cites W1978947245 @default.
• W3085646968 cites W1981786006 @default.
• W3085646968 cites W1982131683 @default.
• W3085646968 cites W1983786214 @default.
• W3085646968 cites W1986303437 @default.
• W3085646968 cites W1987367151 @default.
• W3085646968 cites W1994277524 @default.
• W3085646968 cites W2005908332 @default.
• W3085646968 cites W2009682382 @default.
• W3085646968 cites W2012716464 @default.
• W3085646968 cites W2018331067 @default.
• W3085646968 cites W2018636172 @default.
• W3085646968 cites W2022458862 @default.
• W3085646968 cites W2031879715 @default.
• W3085646968 cites W2032387215 @default.
• W3085646968 cites W2037541029 @default.
• W3085646968 cites W2042023148 @default.
• W3085646968 cites W2046506487 @default.
• W3085646968 cites W2048809849 @default.
• W3085646968 cites W2049036980 @default.
• W3085646968 cites W2051561098 @default.
• W3085646968 cites W2051571572 @default.
• W3085646968 cites W2052024272 @default.
• W3085646968 cites W2068131734 @default.
• W3085646968 cites W2070754746 @default.
• W3085646968 cites W2072397582 @default.
• W3085646968 cites W2072863473 @default.
• W3085646968 cites W2074419829 @default.
• W3085646968 cites W2079747871 @default.
• W3085646968 cites W2083570292 @default.
• W3085646968 cites W2087766414 @default.
• W3085646968 cites W2102234815 @default.
• W3085646968 cites W2117881119 @default.
• W3085646968 cites W2123878217 @default.
• W3085646968 cites W2134239687 @default.
• W3085646968 cites W2137728343 @default.
• W3085646968 cites W2147993763 @default.
• W3085646968 cites W2151276171 @default.
• W3085646968 cites W2155004885 @default.
• W3085646968 cites W2159210012 @default.
• W3085646968 cites W2177381224 @default.
• W3085646968 cites W2178929000 @default.
• W3085646968 cites W2183025438 @default.
• W3085646968 cites W2206135022 @default.
• W3085646968 cites W2214639019 @default.
• W3085646968 cites W2221539544 @default.
• W3085646968 cites W2255757070 @default.
• W3085646968 cites W2255841639 @default.
• W3085646968 cites W2300071193 @default.
• W3085646968 cites W2316203962 @default.
• W3085646968 cites W2326418539 @default.
• W3085646968 cites W2404769653 @default.
• W3085646968 cites W2415086821 @default.
• W3085646968 cites W2485034770 @default.
• W3085646968 cites W2485375858 @default.
• W3085646968 cites W2491639929 @default.
• W3085646968 cites W2507508898 @default.
• W3085646968 cites W2509464877 @default.
• W3085646968 cites W2520518799 @default.
• W3085646968 cites W2524047578 @default.
• W3085646968 cites W2578509772 @default.
• W3085646968 cites W2586345596 @default.
• W3085646968 cites W2587404472 @default.
• W3085646968 cites W2588840597 @default.
• W3085646968 cites W2594065089 @default.
• W3085646968 cites W2596876924 @default.
• W3085646968 cites W2605874626 @default.
• W3085646968 cites W2610037390 @default.
• W3085646968 cites W2613820968 @default.
• W3085646968 cites W2736521173 @default.
• W3085646968 cites W2736621155 @default.
• W3085646968 cites W2738142696 @default.
• W3085646968 cites W2768659948 @default.
• W3085646968 cites W2771154281 @default.
• W3085646968 cites W2771510573 @default.
• W3085646968 cites W2772670881 @default.
• W3085646968 cites W2774970835 @default.
• W3085646968 cites W2782175804 @default.

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