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• W3085687654 endingPage "114" @default.
• W3085687654 startingPage "101" @default.
• W3085687654 abstract "Introduction Schizophrenia is a complex psychiatric disease (or a conglomeration of disorders) manifesting with positive, negative and cognitive symptoms. The pathophysiology of schizophrenia is not completely known; however, it involves many neurotransmitters and their receptors. In order to treat schizophrenia, drugs need to be multi-target drugs. Indeed, the action of second and third generation antipsychotics involves interactions with many receptors, belonging mainly to aminergic GPCRs.Areas covered In this review, the authors summarize current concepts of schizophrenia with the emphasis on the modern dopaminergic, serotoninergic, and glutamatergic hypotheses. Next, they discuss treatments of the disease, stressing multi-target antipsychotics. They cover different aspects of design of multi-target ligands, including the application of molecular modeling approaches for the design and benefits and limitations of multifunctional compounds. Finally, they present successful case studies of multi-target drug design against schizophrenia.Expert opinion Treatment of schizophrenia requires the application of multi-target drugs. While designing single target drugs is relatively easy, designing multifunctional compounds is a challenge due to the necessity to balance the affinity to many targets, while avoiding promiscuity and the problems with drug-likeness. Multi-target drugs bring many benefits: better efficiency, fewer adverse effects, and drug–drug interactions and better patient compliance to drug regime." @default.
• W3085687654 created "2020-09-21" @default.
• W3085687654 creator A5028837075 @default.
• W3085687654 creator A5042546020 @default.
• W3085687654 creator A5057858903 @default.
• W3085687654 creator A5059100019 @default.
• W3085687654 creator A5066476602 @default.
• W3085687654 date "2020-09-11" @default.
• W3085687654 modified "2023-09-27" @default.
• W3085687654 title "Multi-targeted drug design strategies for the treatment of schizophrenia" @default.
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