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- W3085744067 startingPage "113617" @default.
- W3085744067 abstract "Disruption of gut microbiota (GM) composition is increasingly related to the pathogenesis of various metabolic diseases. Additionally, GM is responsible for the production and transformation of metabolites involved in the development of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). The current state of knowledge regarding the composition of GM and GM–related metabolites in relation to the progress and development of obesity and T2DM is presented in this review. To understand the relationships between GM-related metabolites and the development of metabolic disorders, their accurate qualitative and quantitative measurement in biological samples is needed. Feces represent a valuable biological matrix which composition may reflect the health status of the lower gastrointestinal tract and the whole organism. Mass spectrometry (MS), mainly in combination with gas chromatography (GC) or liquid chromatography (LC), is commonly used to measure fecal metabolites. However, profiling metabolites in such a complex matrix as feces is challenging from both analytical chemistry and biochemistry standpoints. Chemical derivatization is one of the most effective methods used to overcome these problems. In this review, we provide a comprehensive summary of the derivatization methods of GM–related metabolites prior to GC–MS or LC–MS analysis, which have been published in the last five years (2015–2020). Additionally, analytical methods used for the analysis of GM-related metabolites without the derivatization step are also presented." @default.
- W3085744067 created "2020-09-21" @default.
- W3085744067 creator A5020642461 @default.
- W3085744067 creator A5042263322 @default.
- W3085744067 creator A5047789308 @default.
- W3085744067 creator A5052856867 @default.
- W3085744067 creator A5087031921 @default.
- W3085744067 date "2020-11-01" @default.
- W3085744067 modified "2023-10-09" @default.
- W3085744067 title "The role of gut microbiota (GM) and GM-related metabolites in diabetes and obesity. A review of analytical methods used to measure GM-related metabolites in fecal samples with a focus on metabolites’ derivatization step" @default.
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