FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085871775> ?p ?o ?g. }

• W3085871775 abstract "Abstract Background Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat symptoms, but underlying mechanism of YHQ treatment for pharyngitis is poorly defined up to now. Methods In this study, the modulation of YHQ on pharyngitis is investigated in ammonia-induced acute pharyngitis rat models. After treatment with YHQ or dexamethasone respectively for five consecutive days, all rats were sacrificed for biomolecular and histopathologic study. Protein expressions of MAPKs, NF-κB, COX-2 and 5-LOX in pharyngitis tissue were evaluated by western blot analysis and the levels of TNF-α, IL-6, prostaglandin (PG) E 2 , leukotrienes (LT)-B 4 and LT-D 4 in pharyngeal tissue were measured via ELISA assay. Evans blue (EB) dye exudation test was performed parallelly to assess the integrity of pharyngeal tissue. Results Compared with normal control group, EB dye exudation, and inflammatory cytokines in the model group were significantly increased, and the pharynx tissue was obviously infiltrated by inflammatory cells. YHQ treatment improved the inflammatory infiltrate in pharyngeal tissue, and reduced EB dye exudation in AP rat models. The up-regulated TNF-α and IL-6 in pharyngeal tissue of AP were significantly reduced by YHQ through inhibition of phosphorylation of p38, Erk and NF-κB. YHQ treatment also reversed the increased level of PGE 2 through down-regulation of COX-2. Conclusions YHQ formula attenuated the pharyngitis related symptoms via suppression of COX-2 and phosphorylation of p38, Erk and NF-κB (p65)." @default.
• W3085871775 created "2020-09-21" @default.
• W3085871775 creator A5021295478 @default.
• W3085871775 creator A5026078968 @default.
• W3085871775 creator A5028148604 @default.
• W3085871775 creator A5029655107 @default.
• W3085871775 creator A5032386807 @default.
• W3085871775 creator A5038371279 @default.
• W3085871775 creator A5049014108 @default.
• W3085871775 creator A5051051559 @default.
• W3085871775 creator A5056450584 @default.
• W3085871775 creator A5060341807 @default.
• W3085871775 creator A5079123535 @default.
• W3085871775 date "2020-09-14" @default.
• W3085871775 modified "2023-10-06" @default.
• W3085871775 title "Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-κB and COX-2" @default.
• W3085871775 cites W1940381503 @default.
• W3085871775 cites W1986199138 @default.
• W3085871775 cites W1998878236 @default.
• W3085871775 cites W2012597520 @default.
• W3085871775 cites W2036606290 @default.
• W3085871775 cites W2036880761 @default.
• W3085871775 cites W2046228597 @default.
• W3085871775 cites W2058053732 @default.
• W3085871775 cites W2081130105 @default.
• W3085871775 cites W2089482846 @default.
• W3085871775 cites W2113401612 @default.
• W3085871775 cites W2309312102 @default.
• W3085871775 cites W2312049299 @default.
• W3085871775 cites W2407380828 @default.
• W3085871775 cites W2465776934 @default.
• W3085871775 cites W2515944892 @default.
• W3085871775 cites W2620769476 @default.
• W3085871775 cites W2752993436 @default.
• W3085871775 cites W2774720313 @default.
• W3085871775 cites W2802862477 @default.
• W3085871775 cites W2891140924 @default.
• W3085871775 cites W2902183435 @default.
• W3085871775 cites W2903503977 @default.
• W3085871775 cites W2911242993 @default.
• W3085871775 cites W2954878886 @default.
• W3085871775 cites W2969489384 @default.
• W3085871775 cites W3045815153 @default.
• W3085871775 cites W3082424266 @default.
• W3085871775 cites W4206233755 @default.
• W3085871775 doi "https://doi.org/10.1186/s12906-020-03077-1" @default.
• W3085871775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7491126" @default.
• W3085871775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32928206" @default.
• W3085871775 hasPublicationYear "2020" @default.
• W3085871775 type Work @default.
• W3085871775 sameAs 3085871775 @default.
• W3085871775 citedByCount "2" @default.
• W3085871775 countsByYear W30858717752022 @default.
• W3085871775 crossrefType "journal-article" @default.
• W3085871775 hasAuthorship W3085871775A5021295478 @default.
• W3085871775 hasAuthorship W3085871775A5026078968 @default.
• W3085871775 hasAuthorship W3085871775A5028148604 @default.
• W3085871775 hasAuthorship W3085871775A5029655107 @default.
• W3085871775 hasAuthorship W3085871775A5032386807 @default.
• W3085871775 hasAuthorship W3085871775A5038371279 @default.
• W3085871775 hasAuthorship W3085871775A5049014108 @default.
• W3085871775 hasAuthorship W3085871775A5051051559 @default.
• W3085871775 hasAuthorship W3085871775A5056450584 @default.
• W3085871775 hasAuthorship W3085871775A5060341807 @default.
• W3085871775 hasAuthorship W3085871775A5079123535 @default.
• W3085871775 hasBestOaLocation W30858717751 @default.
• W3085871775 hasConcept C104317684 @default.
• W3085871775 hasConcept C11960822 @default.
• W3085871775 hasConcept C126322002 @default.
• W3085871775 hasConcept C17991360 @default.
• W3085871775 hasConcept C185592680 @default.
• W3085871775 hasConcept C2776415932 @default.
• W3085871775 hasConcept C2776914184 @default.
• W3085871775 hasConcept C2777730290 @default.
• W3085871775 hasConcept C2779279270 @default.
• W3085871775 hasConcept C2910715184 @default.
• W3085871775 hasConcept C51551487 @default.
• W3085871775 hasConcept C55493867 @default.
• W3085871775 hasConcept C57074206 @default.
• W3085871775 hasConcept C71924100 @default.
• W3085871775 hasConcept C98274493 @default.
• W3085871775 hasConceptScore W3085871775C104317684 @default.
• W3085871775 hasConceptScore W3085871775C11960822 @default.
• W3085871775 hasConceptScore W3085871775C126322002 @default.
• W3085871775 hasConceptScore W3085871775C17991360 @default.
• W3085871775 hasConceptScore W3085871775C185592680 @default.
• W3085871775 hasConceptScore W3085871775C2776415932 @default.
• W3085871775 hasConceptScore W3085871775C2776914184 @default.
• W3085871775 hasConceptScore W3085871775C2777730290 @default.
• W3085871775 hasConceptScore W3085871775C2779279270 @default.
• W3085871775 hasConceptScore W3085871775C2910715184 @default.
• W3085871775 hasConceptScore W3085871775C51551487 @default.
• W3085871775 hasConceptScore W3085871775C55493867 @default.
• W3085871775 hasConceptScore W3085871775C57074206 @default.
• W3085871775 hasConceptScore W3085871775C71924100 @default.
• W3085871775 hasConceptScore W3085871775C98274493 @default.
• W3085871775 hasFunder F4320315254 @default.
• W3085871775 hasIssue "1" @default.
• W3085871775 hasLocation W30858717751 @default.
• W3085871775 hasLocation W30858717752 @default.

• next