Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085909787> ?p ?o ?g. }
- W3085909787 endingPage "6805" @default.
- W3085909787 startingPage "6805" @default.
- W3085909787 abstract "The role of extracellular proteases in cancer progression is well-known, especially in relation to the promotion of cell invasion through extracellular matrix remodeling. This also occurs by the ability of extracellular proteases to induce the shedding of transmembrane proteins at the plasma membrane surface or within extracellular vesicles. This process results in the regulation of key signaling pathways by the modulation of kinases, e.g., the epidermal growth factor receptor (EGFR). Considering their regulatory roles in cancer, therapeutics targeting various extracellular proteases have been discovered. These include the metal-binding agents di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), which increase c-MET degradation by multiple mechanisms. Both the direct and indirect inhibition of protease expression and activity can be achieved through metal ion depletion. Considering direct mechanisms, chelators can bind zinc(II) that plays a catalytic role in enzyme activity. In terms of indirect mechanisms, Dp44mT and DpC potently suppress the expression of the kallikrein-related peptidase—a prostate-specific antigen—in prostate cancer cells. The mechanism of this activity involves promotion of the degradation of the androgen receptor. Additional suppressive mechanisms of Dp44mT and DpC on matrix metalloproteases (MMPs) relate to their ability to up-regulate the metastasis suppressors N-myc downstream regulated gene-1 (NDRG1) and NDRG2, which down-regulate MMPs that are crucial for cancer cell invasion." @default.
- W3085909787 created "2020-09-21" @default.
- W3085909787 creator A5017905338 @default.
- W3085909787 creator A5043686085 @default.
- W3085909787 creator A5079221292 @default.
- W3085909787 date "2020-09-16" @default.
- W3085909787 modified "2023-10-17" @default.
- W3085909787 title "The Role of Extracellular Proteases in Tumor Progression and the Development of Innovative Metal Ion Chelators That Inhibit Their Activity" @default.
- W3085909787 cites W1485015899 @default.
- W3085909787 cites W1502461041 @default.
- W3085909787 cites W1503337666 @default.
- W3085909787 cites W1557061959 @default.
- W3085909787 cites W1563393647 @default.
- W3085909787 cites W1564930378 @default.
- W3085909787 cites W1574172480 @default.
- W3085909787 cites W1889489351 @default.
- W3085909787 cites W1962607015 @default.
- W3085909787 cites W1967869198 @default.
- W3085909787 cites W1968720464 @default.
- W3085909787 cites W1969801754 @default.
- W3085909787 cites W1972513376 @default.
- W3085909787 cites W1972620856 @default.
- W3085909787 cites W1973090023 @default.
- W3085909787 cites W1977373583 @default.
- W3085909787 cites W1978607785 @default.
- W3085909787 cites W1978968754 @default.
- W3085909787 cites W1979390430 @default.
- W3085909787 cites W1984483611 @default.
- W3085909787 cites W1986137370 @default.
- W3085909787 cites W1986884128 @default.
- W3085909787 cites W1989437173 @default.
- W3085909787 cites W1989700814 @default.
- W3085909787 cites W1989824509 @default.
- W3085909787 cites W1992041389 @default.
- W3085909787 cites W1992427599 @default.
- W3085909787 cites W1992660677 @default.
- W3085909787 cites W1993774985 @default.
- W3085909787 cites W1995249913 @default.
- W3085909787 cites W1996100950 @default.
- W3085909787 cites W1997285778 @default.
- W3085909787 cites W1998954104 @default.
- W3085909787 cites W1999005566 @default.
- W3085909787 cites W1999576743 @default.
- W3085909787 cites W1999793633 @default.
- W3085909787 cites W2002526053 @default.
- W3085909787 cites W2002771508 @default.
- W3085909787 cites W2005334224 @default.
- W3085909787 cites W2006628284 @default.
- W3085909787 cites W2009536053 @default.
- W3085909787 cites W2009596161 @default.
- W3085909787 cites W2010571187 @default.
- W3085909787 cites W2010666032 @default.
- W3085909787 cites W2010912389 @default.
- W3085909787 cites W2014698053 @default.
- W3085909787 cites W2016223044 @default.
- W3085909787 cites W2017167084 @default.
- W3085909787 cites W2018692167 @default.
- W3085909787 cites W2018697172 @default.
- W3085909787 cites W2019263501 @default.
- W3085909787 cites W2019473688 @default.
- W3085909787 cites W2020866554 @default.
- W3085909787 cites W2021947345 @default.
- W3085909787 cites W2022180080 @default.
- W3085909787 cites W2022716479 @default.
- W3085909787 cites W2022718682 @default.
- W3085909787 cites W2025962862 @default.
- W3085909787 cites W2027264467 @default.
- W3085909787 cites W2028768078 @default.
- W3085909787 cites W2030262227 @default.
- W3085909787 cites W2032440188 @default.
- W3085909787 cites W2034752268 @default.
- W3085909787 cites W2036148514 @default.
- W3085909787 cites W2037484272 @default.
- W3085909787 cites W2039018871 @default.
- W3085909787 cites W2039732209 @default.
- W3085909787 cites W2042082129 @default.
- W3085909787 cites W2042218168 @default.
- W3085909787 cites W2048172586 @default.
- W3085909787 cites W2049302760 @default.
- W3085909787 cites W2049442302 @default.
- W3085909787 cites W2050481433 @default.
- W3085909787 cites W2051965581 @default.
- W3085909787 cites W2052615856 @default.
- W3085909787 cites W2053700053 @default.
- W3085909787 cites W2055011302 @default.
- W3085909787 cites W2055758035 @default.
- W3085909787 cites W2057234268 @default.
- W3085909787 cites W2060848035 @default.
- W3085909787 cites W2061943904 @default.
- W3085909787 cites W2062421434 @default.
- W3085909787 cites W2063482106 @default.
- W3085909787 cites W2066880239 @default.
- W3085909787 cites W2067342354 @default.
- W3085909787 cites W2071410533 @default.
- W3085909787 cites W2072219853 @default.
- W3085909787 cites W2072375255 @default.
- W3085909787 cites W2072997351 @default.
- W3085909787 cites W2074892413 @default.