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• W3085926716 abstract "Synapses are fundamental information processing units that rely on voltage-gated Ca 2+ (Ca v ) channels to trigger Ca 2+ -dependent neurotransmitter release. Ca v channels also play Ca 2+ -independent roles in other biological contexts, but whether they do so in axon terminals is unknown. Here, we addressed this unknown with respect to the requirement for Ca v 1.4 L-type channels for the formation of rod photoreceptor synapses in the retina. Using a mouse strain expressing a non-conducting mutant form of Ca v 1.4, we report that the Ca v 1.4 protein, but not its Ca 2+ conductance, is required for the molecular assembly of rod synapses; however, Ca v 1.4 Ca 2+ signals are needed for the appropriate recruitment of postsynaptic partners. Our results support a model in which presynaptic Ca v channels serve both as organizers of synaptic building blocks and as sources of Ca 2+ ions in building the first synapse of the visual pathway and perhaps more broadly in the nervous system." @default.
• W3085926716 created "2020-09-21" @default.
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• W3085926716 date "2020-09-17" @default.
• W3085926716 modified "2023-09-29" @default.
• W3085926716 title "A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse" @default.
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• W3085926716 doi "https://doi.org/10.7554/elife.62184" @default.
• W3085926716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7561352" @default.
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