Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085942008> ?p ?o ?g. }
- W3085942008 abstract "Ferric and ferrous iron is an essential transition metal for growth of many bacterial species including mycobacteria. The genomic region msmeg_0234 to msmeg_0252 from Mycobacterium smegmatis is putatively involved in iron/heme metabolism. We investigate the genes encoding the presumed two component system MSMEG_0244/MSMEG_0246, the neighboring gene msmeg_0243 and their involvement in this process. We show that purified MSMEG_0243 indeed is a heme binding protein. Deletion of msmeg_0243/msmeg_0244/msmeg_0246 in Mycobacterium smegmatis leads to a defect in biofilm formation and colony growth on solid agar, however this phenotype is independent of the supplied iron source. Further, analysis of the corresponding mutant and its lipids reveals that changes in morphology and biofilm formation correlate with altered acylation patterns of phosphatidylinositol mannosides (PIMs). We provide the first evidence that msmeg_0244/msmeg_0246 work in concert in cellular lipid homeostasis, especially in the maintenance of PIMs, with the heme-binding protein MSMEG_0243 as potential partner." @default.
- W3085942008 created "2020-09-21" @default.
- W3085942008 creator A5017053622 @default.
- W3085942008 creator A5050096281 @default.
- W3085942008 creator A5053838223 @default.
- W3085942008 creator A5073071263 @default.
- W3085942008 creator A5078340885 @default.
- W3085942008 creator A5087710996 @default.
- W3085942008 date "2020-09-11" @default.
- W3085942008 modified "2023-10-18" @default.
- W3085942008 title "The Two-Component Locus MSMEG_0244/0246 Together With MSMEG_0243 Affects Biofilm Assembly in M. smegmatis Correlating With Changes in Phosphatidylinositol Mannosides Acylation" @default.
- W3085942008 cites W1606765537 @default.
- W3085942008 cites W1608357071 @default.
- W3085942008 cites W1657643071 @default.
- W3085942008 cites W1899324736 @default.
- W3085942008 cites W1964734437 @default.
- W3085942008 cites W1967309271 @default.
- W3085942008 cites W1969945224 @default.
- W3085942008 cites W1974661915 @default.
- W3085942008 cites W1982455880 @default.
- W3085942008 cites W1991130086 @default.
- W3085942008 cites W1991663653 @default.
- W3085942008 cites W1996907187 @default.
- W3085942008 cites W2008554986 @default.
- W3085942008 cites W2011702801 @default.
- W3085942008 cites W2017228544 @default.
- W3085942008 cites W2028819914 @default.
- W3085942008 cites W2033474113 @default.
- W3085942008 cites W2035787643 @default.
- W3085942008 cites W2046928094 @default.
- W3085942008 cites W2051993645 @default.
- W3085942008 cites W2071932302 @default.
- W3085942008 cites W2081786749 @default.
- W3085942008 cites W2084171643 @default.
- W3085942008 cites W2087324091 @default.
- W3085942008 cites W2090311177 @default.
- W3085942008 cites W2090601506 @default.
- W3085942008 cites W2092941764 @default.
- W3085942008 cites W2094665761 @default.
- W3085942008 cites W2099540110 @default.
- W3085942008 cites W2124932855 @default.
- W3085942008 cites W2138410704 @default.
- W3085942008 cites W2140649128 @default.
- W3085942008 cites W2144089610 @default.
- W3085942008 cites W2147315750 @default.
- W3085942008 cites W2152257820 @default.
- W3085942008 cites W2152378366 @default.
- W3085942008 cites W2155375392 @default.
- W3085942008 cites W2157824802 @default.
- W3085942008 cites W2158545949 @default.
- W3085942008 cites W2165019884 @default.
- W3085942008 cites W2166578833 @default.
- W3085942008 cites W2168526937 @default.
- W3085942008 cites W2293207343 @default.
- W3085942008 cites W2469547405 @default.
- W3085942008 cites W2507431544 @default.
- W3085942008 cites W2551257139 @default.
- W3085942008 cites W2580805279 @default.
- W3085942008 cites W2593911600 @default.
- W3085942008 cites W2616315171 @default.
- W3085942008 cites W2735401266 @default.
- W3085942008 cites W2740459087 @default.
- W3085942008 cites W2766741071 @default.
- W3085942008 cites W2799802207 @default.
- W3085942008 cites W2807213190 @default.
- W3085942008 cites W2887133792 @default.
- W3085942008 cites W2901545219 @default.
- W3085942008 cites W2954630490 @default.
- W3085942008 cites W2962771066 @default.
- W3085942008 cites W2973853581 @default.
- W3085942008 cites W2992333284 @default.
- W3085942008 cites W2996818283 @default.
- W3085942008 doi "https://doi.org/10.3389/fmicb.2020.570606" @default.
- W3085942008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7516205" @default.
- W3085942008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33013801" @default.
- W3085942008 hasPublicationYear "2020" @default.
- W3085942008 type Work @default.
- W3085942008 sameAs 3085942008 @default.
- W3085942008 citedByCount "3" @default.
- W3085942008 countsByYear W30859420082021 @default.
- W3085942008 countsByYear W30859420082022 @default.
- W3085942008 crossrefType "journal-article" @default.
- W3085942008 hasAuthorship W3085942008A5017053622 @default.
- W3085942008 hasAuthorship W3085942008A5050096281 @default.
- W3085942008 hasAuthorship W3085942008A5053838223 @default.
- W3085942008 hasAuthorship W3085942008A5073071263 @default.
- W3085942008 hasAuthorship W3085942008A5078340885 @default.
- W3085942008 hasAuthorship W3085942008A5087710996 @default.
- W3085942008 hasBestOaLocation W30859420081 @default.
- W3085942008 hasConcept C104317684 @default.
- W3085942008 hasConcept C142724271 @default.
- W3085942008 hasConcept C143065580 @default.
- W3085942008 hasConcept C161790260 @default.
- W3085942008 hasConcept C185592680 @default.
- W3085942008 hasConcept C193557335 @default.
- W3085942008 hasConcept C2777204207 @default.
- W3085942008 hasConcept C2777975735 @default.
- W3085942008 hasConcept C2781069245 @default.
- W3085942008 hasConcept C523546767 @default.
- W3085942008 hasConcept C54355233 @default.