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• W3085963485 startingPage "540" @default.
• W3085963485 abstract "Technology platforms are an important strategy to facilitate the design, development and implementation of vaccines to combat high-burden diseases that are still a threat for human populations, especially in low- and middle-income countries, and to address the increasing number and global distribution of pathogens resistant to antimicrobial drugs. Generalized Modules for Membrane Antigens (GMMA), outer membrane vesicles derived from engineered Gram-negative bacteria, represent an attractive technology to design affordable vaccines. Here, we show that GMMA, decorated with heterologous polysaccharide or protein antigens, leads to a strong and effective antigen-specific humoral immune response in mice. Importantly, GMMA promote enhanced immunogenicity compared to traditional formulations (e.g., recombinant proteins and glycoconjugate vaccines), without negative impact to the anti-GMMA immune response. Our findings support the use of GMMA as a plug and play technology for the development of effective combination vaccines targeting different bugs at the same time." @default.
• W3085963485 created "2020-09-21" @default.
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• W3085963485 date "2020-09-17" @default.
• W3085963485 modified "2023-10-13" @default.
• W3085963485 title "GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines" @default.
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• W3085963485 doi "https://doi.org/10.3390/vaccines8030540" @default.
• W3085963485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7564227" @default.
• W3085963485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32957610" @default.
• W3085963485 hasPublicationYear "2020" @default.
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