FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3085995004> ?p ?o ?g. }

• W3085995004 endingPage "7079" @default.
• W3085995004 startingPage "7067" @default.
• W3085995004 abstract "Site-selective uptake and specific biodistribution of chemotherapeutic drugs are essential prerequisites for targeted cancer therapy. Especially, antibody and peptide conjugated drugs have been attempted as localized therapeutic agents. However, the characteristics of drug conjugated nanosystems are less explored, which are limited with their toxicity, low therapeutic efficacy, complicated synthesis, and high costs. Herein, we report a biocompatible (about 95%) molecularly engineered anticancer drug conjugated nanomicelles (∼200 nm in size) for site-selective CD44 overexpressed cancer cell rupture and tumor growth inhibition. Microscopic analysis demonstrates the distinct visualization of organic-organic interfaces (∼5 nm), which are corroborated with spectroscopic measurements confirmed the conjugation of niclosamide drug with hyaluronic acid (NIC-HA). Uniformly distributed hemocompatible (about 99%) organic nanomicelles exhibit the cellular membrane and cytoplasmic targeting with significant cellular rupture (IC50 of 4 μM for MDA MB 231 cells) indicating their inherent targeting ability for cancer cells and cancer stem cells. An inclusive in vitro and in vivo analysis for targeted antitumor activity (HT1080 tumor xenograft model) of NIC-HA nanoconjugates (∼24.6% loading) exhibited promising cancer cell death and tumor growth inhibition (60%, p < 0.05) due to STAT-3 signaling pathway inhibition and induction of apoptosis in CD44-positive triple negative breast cancer cells." @default.
• W3085995004 created "2020-09-21" @default.
• W3085995004 creator A5030188730 @default.
• W3085995004 creator A5037362936 @default.
• W3085995004 creator A5054197081 @default.
• W3085995004 creator A5058750227 @default.
• W3085995004 creator A5069832459 @default.
• W3085995004 creator A5082164198 @default.
• W3085995004 creator A5091581242 @default.
• W3085995004 date "2020-09-09" @default.
• W3085995004 modified "2023-10-16" @default.
• W3085995004 title "Characteristics of Molecularly Engineered Anticancer Drug Conjugated Organic Nanomicelles for Site-Selective Cancer Cell Rupture and Growth Inhibition of Tumor Spheroids" @default.
• W3085995004 cites W1558905924 @default.
• W3085995004 cites W1909499926 @default.
• W3085995004 cites W1967200224 @default.
• W3085995004 cites W1976278209 @default.
• W3085995004 cites W1976544205 @default.
• W3085995004 cites W1986897981 @default.
• W3085995004 cites W2024436494 @default.
• W3085995004 cites W2027876233 @default.
• W3085995004 cites W2033281188 @default.
• W3085995004 cites W2038626534 @default.
• W3085995004 cites W2088632292 @default.
• W3085995004 cites W2094305477 @default.
• W3085995004 cites W2098318720 @default.
• W3085995004 cites W2103914087 @default.
• W3085995004 cites W2127126241 @default.
• W3085995004 cites W2129659516 @default.
• W3085995004 cites W2133486199 @default.
• W3085995004 cites W2134066485 @default.
• W3085995004 cites W2137354818 @default.
• W3085995004 cites W2143463421 @default.
• W3085995004 cites W2144030492 @default.
• W3085995004 cites W2160855995 @default.
• W3085995004 cites W2165278773 @default.
• W3085995004 cites W2216239984 @default.
• W3085995004 cites W2323921672 @default.
• W3085995004 cites W2603732925 @default.
• W3085995004 cites W2605112455 @default.
• W3085995004 cites W2612934592 @default.
• W3085995004 cites W2613352698 @default.
• W3085995004 cites W2624864065 @default.
• W3085995004 cites W2754823840 @default.
• W3085995004 cites W2762341360 @default.
• W3085995004 cites W2770658485 @default.
• W3085995004 cites W2784945413 @default.
• W3085995004 cites W2791859190 @default.
• W3085995004 cites W2792845600 @default.
• W3085995004 cites W2796576424 @default.
• W3085995004 cites W2806713886 @default.
• W3085995004 cites W2888647729 @default.
• W3085995004 cites W2890167612 @default.
• W3085995004 cites W2897979644 @default.
• W3085995004 cites W2901420297 @default.
• W3085995004 cites W2954597343 @default.
• W3085995004 cites W2971222818 @default.
• W3085995004 cites W2994840508 @default.
• W3085995004 cites W3004362771 @default.
• W3085995004 cites W3005377620 @default.
• W3085995004 cites W3010190156 @default.
• W3085995004 cites W3016129808 @default.
• W3085995004 cites W3034093264 @default.
• W3085995004 cites W3082283970 @default.
• W3085995004 doi "https://doi.org/10.1021/acsabm.0c00913" @default.
• W3085995004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35019366" @default.
• W3085995004 hasPublicationYear "2020" @default.
• W3085995004 type Work @default.
• W3085995004 sameAs 3085995004 @default.
• W3085995004 citedByCount "4" @default.
• W3085995004 countsByYear W30859950042021 @default.
• W3085995004 countsByYear W30859950042022 @default.
• W3085995004 crossrefType "journal-article" @default.
• W3085995004 hasAuthorship W3085995004A5030188730 @default.
• W3085995004 hasAuthorship W3085995004A5037362936 @default.
• W3085995004 hasAuthorship W3085995004A5054197081 @default.
• W3085995004 hasAuthorship W3085995004A5058750227 @default.
• W3085995004 hasAuthorship W3085995004A5069832459 @default.
• W3085995004 hasAuthorship W3085995004A5082164198 @default.
• W3085995004 hasAuthorship W3085995004A5091581242 @default.
• W3085995004 hasConcept C121608353 @default.
• W3085995004 hasConcept C126322002 @default.
• W3085995004 hasConcept C1491633281 @default.
• W3085995004 hasConcept C185592680 @default.
• W3085995004 hasConcept C2780932548 @default.
• W3085995004 hasConcept C502942594 @default.
• W3085995004 hasConcept C55493867 @default.
• W3085995004 hasConcept C71924100 @default.
• W3085995004 hasConcept C96232424 @default.
• W3085995004 hasConceptScore W3085995004C121608353 @default.
• W3085995004 hasConceptScore W3085995004C126322002 @default.
• W3085995004 hasConceptScore W3085995004C1491633281 @default.
• W3085995004 hasConceptScore W3085995004C185592680 @default.
• W3085995004 hasConceptScore W3085995004C2780932548 @default.
• W3085995004 hasConceptScore W3085995004C502942594 @default.
• W3085995004 hasConceptScore W3085995004C55493867 @default.
• W3085995004 hasConceptScore W3085995004C71924100 @default.
• W3085995004 hasConceptScore W3085995004C96232424 @default.
• W3085995004 hasIssue "10" @default.

• next