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- W3086092904 endingPage "1318" @default.
- W3086092904 startingPage "1280" @default.
- W3086092904 abstract "Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate production. Cytochrome bd is found in many bacterial pathogens and, surprisingly, in bacteria formally denoted as anaerobes. It endows bacteria with resistance to various stressors and is a potential drug target. Recent Advances: We summarize recent advances in the biochemistry, structure, and physiological functions of cytochrome bd in the light of exciting new three-dimensional structures of the oxidase. The newly discovered roles of cytochrome bd in contributing to bacterial protection against hydrogen peroxide, nitric oxide, peroxynitrite, and hydrogen sulfide are assessed. Critical Issues: Fundamental questions remain regarding the precise delineation of electron flow within this multihaem oxidase and how the extraordinarily high affinity for oxygen is accomplished, while endowing bacteria with resistance to other small ligands. Future Directions: It is clear that cytochrome bd is unique in its ability to confer resistance to toxic small molecules, a property that is significant for understanding the propensity of pathogens to possess this oxidase. Since cytochrome bd is a uniquely bacterial enzyme, future research should focus on harnessing fundamental knowledge of its structure and function to the development of novel and effective antibacterial agents." @default.
- W3086092904 created "2020-09-21" @default.
- W3086092904 creator A5001298745 @default.
- W3086092904 creator A5008614222 @default.
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- W3086092904 creator A5035683021 @default.
- W3086092904 creator A5067090345 @default.
- W3086092904 creator A5086614949 @default.
- W3086092904 date "2021-06-01" @default.
- W3086092904 modified "2023-10-12" @default.
- W3086092904 title "Bacterial Oxidases of the Cytochrome<i>bd</i>Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets" @default.
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