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- W3086108939 abstract "The bifunctional nsp14 subunit of the coronavirus replicase contains 3′-to-5′ exoribonuclease (ExoN) and guanine-N7-methyltransferase domains. For the betacoronaviruses MHV and SARS-CoV, ExoN was reported to promote the fidelity of genome replication, presumably by mediating a form of proofreading. For these viruses, ExoN knockout mutants are viable while displaying an increased mutation frequency. Strikingly, we have now established that the equivalent ExoN knockout mutants of two other betacoronaviruses, MERS-CoV and SARS-CoV-2, are nonviable, suggesting an additional and critical ExoN function in their replication. This is remarkable in light of the very limited genetic distance between SARS-CoV and SARS-CoV-2, which is highlighted, for example, by 95% amino acid sequence identity in their nsp14 sequences. For (recombinant) MERS-CoV nsp14, both its enzymatic activities were evaluated using newly developed in vitro assays that can be used to characterize these key replicative enzymes in more detail and explore their potential as target for antiviral drug development." @default.
- W3086108939 created "2020-09-21" @default.
- W3086108939 creator A5005160187 @default.
- W3086108939 creator A5010959513 @default.
- W3086108939 creator A5028723144 @default.
- W3086108939 creator A5064322566 @default.
- W3086108939 creator A5084530245 @default.
- W3086108939 creator A5090665639 @default.
- W3086108939 date "2020-11-09" @default.
- W3086108939 modified "2023-10-10" @default.
- W3086108939 title "The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2" @default.
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