SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086130565> ?p ?o ?g. }

Showing items 1 to 100 of ±124 with 100 items per page.

W3086130565 endingPage "17680" @default.
W3086130565 startingPage "17662" @default.
W3086130565 abstract "Development of resistance to tyrosine kinase inhibitors (TKIs) targeting the BCR/ABL fusion protein represents a major challenge in the treatment of chronic myeloid leukemia (CML). Since apoptosis resistance is the fundamental mechanism impeding TKIs' therapeutic effects, alternative approaches that induce nonapoptotic cell death are being pursued to treat TKI-resistant CML. Induction of necroptosis, a distinct, caspase-independent form of programmed cell death, may be a valuable strategy in this respect. The present study shows that shikonin, an herbal compound used in traditional Chinese medicine, overcomes TKI resistance in BCR/ABL-positive CML cells by inducing necroptosis via activation of RIPK1/RIPK3/MLKL signaling. This effect occurs both in vitro and in vivo and involves downregulation of miR-92a-1-5p, a poor-prognosis marker frequently overexpressed in leukemia patients. Based on gene expression experiments, we conclude that miR-92a-1-5p promotes CML progression by inhibiting MLKL expression. Accordingly, we show that antagomiR-mediated in vivo inhibition of miR-92a-1-5p reduces the growth of CML tumors in mice through necroptosis induction. Our research suggests that therapies that relieve MLKL suppression by targeting miR-92a-1-5p may represent a useful strategy to treat TKI-refractory CML." @default.
W3086130565 created "2020-09-21" @default.
W3086130565 creator A5029641417 @default.
W3086130565 creator A5059854566 @default.
W3086130565 creator A5063046811 @default.
W3086130565 creator A5067469709 @default.
W3086130565 creator A5077751475 @default.
W3086130565 date "2020-09-14" @default.
W3086130565 modified "2023-10-12" @default.
W3086130565 title "Shikonin overcomes drug resistance and induces necroptosis by regulating the miR-92a-1-5p/MLKL axis in chronic myeloid leukemia" @default.
W3086130565 cites W1529003705 @default.
W3086130565 cites W1533454846 @default.
W3086130565 cites W1823204499 @default.
W3086130565 cites W1945652054 @default.
W3086130565 cites W1966358179 @default.
W3086130565 cites W1987213099 @default.
W3086130565 cites W1987707979 @default.
W3086130565 cites W2007633189 @default.
W3086130565 cites W2008408444 @default.
W3086130565 cites W2015419250 @default.
W3086130565 cites W2017367722 @default.
W3086130565 cites W2033595939 @default.
W3086130565 cites W2062486143 @default.
W3086130565 cites W2064096260 @default.
W3086130565 cites W2064109729 @default.
W3086130565 cites W2065177893 @default.
W3086130565 cites W2069664794 @default.
W3086130565 cites W2081053802 @default.
W3086130565 cites W2084887234 @default.
W3086130565 cites W2087232320 @default.
W3086130565 cites W2088599644 @default.
W3086130565 cites W2089769997 @default.
W3086130565 cites W2091134276 @default.
W3086130565 cites W2091363184 @default.
W3086130565 cites W2093247413 @default.
W3086130565 cites W2096171205 @default.
W3086130565 cites W2104694028 @default.
W3086130565 cites W2105343186 @default.
W3086130565 cites W2107411016 @default.
W3086130565 cites W2110796758 @default.
W3086130565 cites W2153151008 @default.
W3086130565 cites W2283739034 @default.
W3086130565 cites W2343861412 @default.
W3086130565 cites W2419929266 @default.
W3086130565 cites W2521977066 @default.
W3086130565 cites W2619922326 @default.
W3086130565 cites W2745337591 @default.
W3086130565 cites W2904964809 @default.
W3086130565 cites W2947880033 @default.
W3086130565 cites W4242587027 @default.
W3086130565 doi "https://doi.org/10.18632/aging.103844" @default.
W3086130565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7521527" @default.
W3086130565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32927433" @default.
W3086130565 hasPublicationYear "2020" @default.
W3086130565 type Work @default.
W3086130565 sameAs 3086130565 @default.
W3086130565 citedByCount "13" @default.
W3086130565 countsByYear W30861305652021 @default.
W3086130565 countsByYear W30861305652022 @default.
W3086130565 countsByYear W30861305652023 @default.
W3086130565 crossrefType "journal-article" @default.
W3086130565 hasAuthorship W3086130565A5029641417 @default.
W3086130565 hasAuthorship W3086130565A5059854566 @default.
W3086130565 hasAuthorship W3086130565A5063046811 @default.
W3086130565 hasAuthorship W3086130565A5067469709 @default.
W3086130565 hasAuthorship W3086130565A5077751475 @default.
W3086130565 hasBestOaLocation W30861305651 @default.
W3086130565 hasConcept C104317684 @default.
W3086130565 hasConcept C127561419 @default.
W3086130565 hasConcept C150903083 @default.
W3086130565 hasConcept C190283241 @default.
W3086130565 hasConcept C203014093 @default.
W3086130565 hasConcept C207001950 @default.
W3086130565 hasConcept C2778461978 @default.
W3086130565 hasConcept C2778729363 @default.
W3086130565 hasConcept C31573885 @default.
W3086130565 hasConcept C42362537 @default.
W3086130565 hasConcept C502942594 @default.
W3086130565 hasConcept C55493867 @default.
W3086130565 hasConcept C62478195 @default.
W3086130565 hasConcept C71924100 @default.
W3086130565 hasConcept C86803240 @default.
W3086130565 hasConcept C94030615 @default.
W3086130565 hasConcept C95444343 @default.
W3086130565 hasConceptScore W3086130565C104317684 @default.
W3086130565 hasConceptScore W3086130565C127561419 @default.
W3086130565 hasConceptScore W3086130565C150903083 @default.
W3086130565 hasConceptScore W3086130565C190283241 @default.
W3086130565 hasConceptScore W3086130565C203014093 @default.
W3086130565 hasConceptScore W3086130565C207001950 @default.
W3086130565 hasConceptScore W3086130565C2778461978 @default.
W3086130565 hasConceptScore W3086130565C2778729363 @default.
W3086130565 hasConceptScore W3086130565C31573885 @default.
W3086130565 hasConceptScore W3086130565C42362537 @default.
W3086130565 hasConceptScore W3086130565C502942594 @default.
W3086130565 hasConceptScore W3086130565C55493867 @default.
W3086130565 hasConceptScore W3086130565C62478195 @default.
W3086130565 hasConceptScore W3086130565C71924100 @default.