Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086151011> ?p ?o ?g. }
- W3086151011 endingPage "496" @default.
- W3086151011 startingPage "485" @default.
- W3086151011 abstract "The objective of this open-label, randomized study was to compare dose-dense paclitaxel plus carboplatin (PCdd) with dose-dense epirubicin and cyclophosphamide followed by paclitaxel (ECdd-P) as an adjuvant chemotherapy for early triple-negative breast cancer (TNBC).We included Chinese patients with high recurrence risk TNBC who underwent primary breast cancer surgery. They were randomly assigned to receive PCdd [paclitaxel 150 mg/m2 on d 1 and carboplatin, the area under the curve, (AUC)=3 on d 2] or ECdd-P (epirubicin 80 mg/m2 divided in 2 d and cyclophosphamide 600 mg/m2 on d 1 for 4 cycles followed by paclitaxel 175 mg/m2 on d 1 for 4 cycles) every 2 weeks with granulocyte colony-stimulating factor (G-CSF) support. The primary endpoint was 3-year disease-free survival (DFS); the secondary endpoints were overall survival (OS) and safety.The intent-to-treat population included 143 patients (70 in the PCdd arm and 73 in the ECdd-P arm). Compared with the ECdd-P arm, the PCdd arm had significantly higher 3-year DFS [93.9% vs. 79.1%; hazard ratio (HR)=0.310; 95% confidence interval (95% CI), 0.137-0.704; log-rank, P=0.005] and OS (98.5% vs. 92.9%; HR=0.142; 95% CI, 0.060-0.825; log-rank, P=0.028). Worse neutropenia (grade 3/4) was found in the ECdd-P than the PCdd arm (47.9% vs. 21.4%, P=0.001).PCdd was superior to ECdd-P as an adjuvant chemotherapy for early TNBC with respect to improving the 3-year DFS and OS. PCdd also yielded lower hematological toxicity. Thus, PCdd might be a preferred regimen for early TNBC patients with a high recurrence risk." @default.
- W3086151011 created "2020-09-21" @default.
- W3086151011 creator A5008098651 @default.
- W3086151011 creator A5008584660 @default.
- W3086151011 creator A5011968094 @default.
- W3086151011 creator A5012563966 @default.
- W3086151011 creator A5019200264 @default.
- W3086151011 creator A5024893578 @default.
- W3086151011 creator A5029901536 @default.
- W3086151011 creator A5047620654 @default.
- W3086151011 creator A5049054503 @default.
- W3086151011 creator A5051415080 @default.
- W3086151011 creator A5079620519 @default.
- W3086151011 creator A5091207696 @default.
- W3086151011 date "2020-01-01" @default.
- W3086151011 modified "2023-09-30" @default.
- W3086151011 title "Dose-dense paclitaxel plus carboplatin vs. epirubicin and cyclophosphamide with paclitaxel as adjuvant chemotherapy for high-risk triple-negative breast cancer" @default.
- W3086151011 cites W1256125786 @default.
- W3086151011 cites W1858470829 @default.
- W3086151011 cites W1863683188 @default.
- W3086151011 cites W1997636374 @default.
- W3086151011 cites W2014179352 @default.
- W3086151011 cites W2048362391 @default.
- W3086151011 cites W2086064725 @default.
- W3086151011 cites W2096027508 @default.
- W3086151011 cites W2096745115 @default.
- W3086151011 cites W2101760255 @default.
- W3086151011 cites W2123528875 @default.
- W3086151011 cites W2137853125 @default.
- W3086151011 cites W2142486051 @default.
- W3086151011 cites W2164214273 @default.
- W3086151011 cites W2170602872 @default.
- W3086151011 cites W2170719826 @default.
- W3086151011 cites W2215157211 @default.
- W3086151011 cites W2295085830 @default.
- W3086151011 cites W2336410037 @default.
- W3086151011 cites W2399127659 @default.
- W3086151011 cites W2472635452 @default.
- W3086151011 cites W2561439167 @default.
- W3086151011 cites W2580300085 @default.
- W3086151011 cites W2613421724 @default.
- W3086151011 cites W2617852931 @default.
- W3086151011 cites W2652729657 @default.
- W3086151011 cites W2734897937 @default.
- W3086151011 cites W2745227329 @default.
- W3086151011 cites W2760874931 @default.
- W3086151011 cites W2788106879 @default.
- W3086151011 cites W2792761659 @default.
- W3086151011 cites W2807418950 @default.
- W3086151011 cites W2808672171 @default.
- W3086151011 cites W2885684012 @default.
- W3086151011 cites W2887014156 @default.
- W3086151011 cites W2900875709 @default.
- W3086151011 cites W2903044532 @default.
- W3086151011 cites W2912785950 @default.
- W3086151011 cites W2913286462 @default.
- W3086151011 cites W2915710933 @default.
- W3086151011 cites W2925711482 @default.
- W3086151011 cites W2962575863 @default.
- W3086151011 cites W2965857754 @default.
- W3086151011 cites W2974316995 @default.
- W3086151011 cites W2986569805 @default.
- W3086151011 cites W3024892376 @default.
- W3086151011 doi "https://doi.org/10.21147/j.issn.1000-9604.2020.04.06" @default.
- W3086151011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7491545" @default.
- W3086151011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32963461" @default.
- W3086151011 hasPublicationYear "2020" @default.
- W3086151011 type Work @default.
- W3086151011 sameAs 3086151011 @default.
- W3086151011 citedByCount "7" @default.
- W3086151011 countsByYear W30861510112021 @default.
- W3086151011 countsByYear W30861510112022 @default.
- W3086151011 countsByYear W30861510112023 @default.
- W3086151011 crossrefType "journal-article" @default.
- W3086151011 hasAuthorship W3086151011A5008098651 @default.
- W3086151011 hasAuthorship W3086151011A5008584660 @default.
- W3086151011 hasAuthorship W3086151011A5011968094 @default.
- W3086151011 hasAuthorship W3086151011A5012563966 @default.
- W3086151011 hasAuthorship W3086151011A5019200264 @default.
- W3086151011 hasAuthorship W3086151011A5024893578 @default.
- W3086151011 hasAuthorship W3086151011A5029901536 @default.
- W3086151011 hasAuthorship W3086151011A5047620654 @default.
- W3086151011 hasAuthorship W3086151011A5049054503 @default.
- W3086151011 hasAuthorship W3086151011A5051415080 @default.
- W3086151011 hasAuthorship W3086151011A5079620519 @default.
- W3086151011 hasAuthorship W3086151011A5091207696 @default.
- W3086151011 hasBestOaLocation W30861510111 @default.
- W3086151011 hasConcept C121608353 @default.
- W3086151011 hasConcept C126322002 @default.
- W3086151011 hasConcept C126894567 @default.
- W3086151011 hasConcept C143998085 @default.
- W3086151011 hasConcept C168563851 @default.
- W3086151011 hasConcept C203092338 @default.
- W3086151011 hasConcept C207103383 @default.
- W3086151011 hasConcept C2776694085 @default.
- W3086151011 hasConcept C2776755627 @default.
- W3086151011 hasConcept C2777292972 @default.
- W3086151011 hasConcept C2778239845 @default.