FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086171312> ?p ?o ?g. }

• W3086171312 endingPage "970" @default.
• W3086171312 startingPage "963" @default.
• W3086171312 abstract "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease (COVID-19) that has resulted in a global pandemic. At the time of writing, approximately 16.06 million cases have been reported worldwide. Like other coronaviruses, SARS-CoV-2 relies on the surface Spike glycoprotein to access the host cells, mainly through the interaction of its Receptor Binding Domain (RBD) with the host receptor Angiotensin-Converting Enzyme2 (ACE2). SARS-CoV-2 infection induces a profound downstream pro-inflammatory cytokine storm. This release of the pro-inflammatory cytokines is underpinning lung tissue damage, respiratory failure, and eventually multiple organ failure in COVID-19 patients. The phosphorylation status of ERK1/2 is positively correlated with virus load and ERK1/2 inhibition suppressed viral replication and viral infectivity. Therefore, molecular entities able to interfere with binding of the SARS-CoV-2 Spike protein to ACE2, or damping hyperinflammatory cytokines storm, blocking ERK1/2 phosphorylation have a great potential to inhibit viral entry along with viral infectivity. Herein, we report that the FDA-approved non-peptide opioid antagonist drug, naltrexone suppresses high fat/LPS induced pro-inflammatory cytokine release both from macrophage cells and Adipose Tissue Macrophage. Moreover, Low Dose Naltrexone (LDN) also showed its activity as an ERK1/2 inhibitor. Notably, virtual docking and simulation data also suggest LDN may disrupt the interaction of ACE2 with RBD. LDN may be considered as a target as the treatment and (or) adjuvant therapy for coronavirus infection. Clinical toxicity measurements may not be required for LDN since naltrexone was previously tested and is an approved drug by the FDA.Communicated by Ramaswamy H. Sarma." @default.
• W3086171312 created "2020-09-21" @default.
• W3086171312 creator A5018948305 @default.
• W3086171312 creator A5022950768 @default.
• W3086171312 creator A5060164148 @default.
• W3086171312 creator A5076728587 @default.
• W3086171312 creator A5083907457 @default.
• W3086171312 date "2020-09-15" @default.
• W3086171312 modified "2023-10-18" @default.
• W3086171312 title "Naltrexone a potential therapeutic candidate for COVID-19" @default.
• W3086171312 cites W1031578623 @default.
• W3086171312 cites W1980154695 @default.
• W3086171312 cites W1994758637 @default.
• W3086171312 cites W1997198225 @default.
• W3086171312 cites W2013640555 @default.
• W3086171312 cites W2030028793 @default.
• W3086171312 cites W2031636010 @default.
• W3086171312 cites W2054076340 @default.
• W3086171312 cites W2060433756 @default.
• W3086171312 cites W2076911722 @default.
• W3086171312 cites W2105668062 @default.
• W3086171312 cites W2107277218 @default.
• W3086171312 cites W2108163830 @default.
• W3086171312 cites W2165305033 @default.
• W3086171312 cites W2212127474 @default.
• W3086171312 cites W2241722503 @default.
• W3086171312 cites W2412243856 @default.
• W3086171312 cites W2471732223 @default.
• W3086171312 cites W2555394422 @default.
• W3086171312 cites W2607401549 @default.
• W3086171312 cites W2735653622 @default.
• W3086171312 cites W2807702373 @default.
• W3086171312 cites W2891868538 @default.
• W3086171312 cites W2896393803 @default.
• W3086171312 cites W2912976592 @default.
• W3086171312 cites W3003217347 @default.
• W3086171312 cites W3004318991 @default.
• W3086171312 cites W3009335299 @default.
• W3086171312 cites W3009489304 @default.
• W3086171312 cites W3009799538 @default.
• W3086171312 cites W3009912996 @default.
• W3086171312 cites W3012515447 @default.
• W3086171312 cites W3012655019 @default.
• W3086171312 cites W3013949914 @default.
• W3086171312 cites W3014067025 @default.
• W3086171312 cites W3015035592 @default.
• W3086171312 cites W3016585006 @default.
• W3086171312 cites W3017730472 @default.
• W3086171312 cites W3021577619 @default.
• W3086171312 cites W3036508518 @default.
• W3086171312 cites W3046445222 @default.
• W3086171312 doi "https://doi.org/10.1080/07391102.2020.1820379" @default.
• W3086171312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7544934" @default.
• W3086171312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32930058" @default.
• W3086171312 hasPublicationYear "2020" @default.
• W3086171312 type Work @default.
• W3086171312 sameAs 3086171312 @default.
• W3086171312 citedByCount "16" @default.
• W3086171312 countsByYear W30861713122021 @default.
• W3086171312 countsByYear W30861713122022 @default.
• W3086171312 countsByYear W30861713122023 @default.
• W3086171312 crossrefType "journal-article" @default.
• W3086171312 hasAuthorship W3086171312A5018948305 @default.
• W3086171312 hasAuthorship W3086171312A5022950768 @default.
• W3086171312 hasAuthorship W3086171312A5060164148 @default.
• W3086171312 hasAuthorship W3086171312A5076728587 @default.
• W3086171312 hasAuthorship W3086171312A5083907457 @default.
• W3086171312 hasBestOaLocation W30861713122 @default.
• W3086171312 hasConcept C106358424 @default.
• W3086171312 hasConcept C126322002 @default.
• W3086171312 hasConcept C140704245 @default.
• W3086171312 hasConcept C142462285 @default.
• W3086171312 hasConcept C159047783 @default.
• W3086171312 hasConcept C170493617 @default.
• W3086171312 hasConcept C203014093 @default.
• W3086171312 hasConcept C2522874641 @default.
• W3086171312 hasConcept C2776885963 @default.
• W3086171312 hasConcept C2777648638 @default.
• W3086171312 hasConcept C2777972943 @default.
• W3086171312 hasConcept C2779134260 @default.
• W3086171312 hasConcept C2779559532 @default.
• W3086171312 hasConcept C2780850621 @default.
• W3086171312 hasConcept C3008058167 @default.
• W3086171312 hasConcept C524204448 @default.
• W3086171312 hasConcept C71924100 @default.
• W3086171312 hasConcept C86803240 @default.
• W3086171312 hasConcept C98274493 @default.
• W3086171312 hasConceptScore W3086171312C106358424 @default.
• W3086171312 hasConceptScore W3086171312C126322002 @default.
• W3086171312 hasConceptScore W3086171312C140704245 @default.
• W3086171312 hasConceptScore W3086171312C142462285 @default.
• W3086171312 hasConceptScore W3086171312C159047783 @default.
• W3086171312 hasConceptScore W3086171312C170493617 @default.
• W3086171312 hasConceptScore W3086171312C203014093 @default.
• W3086171312 hasConceptScore W3086171312C2522874641 @default.
• W3086171312 hasConceptScore W3086171312C2776885963 @default.
• W3086171312 hasConceptScore W3086171312C2777648638 @default.
• W3086171312 hasConceptScore W3086171312C2777972943 @default.

• next