FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086238538> ?p ?o ?g. }

• W3086238538 abstract "Abstract Background Plasmodium falciparum parasites are known to exhibit extensive genetic diversity in areas of high transmission intensity and infected individuals in such communities often harbour several complex mixtures of parasite clones with different genetic characteristics. However, in the micro-environment, the extent of genetic diversity of P. falciparum parasites remain largely unknown. In this study therefore, the complexity of P. falciparum infections in households was investigated among symptomatic siblings, living under the same roof in north-central Nigeria. Methods Children were enrolled into the study if they were at least two from a household and presented with symptoms of uncomplicated malaria. Clinical malaria was confirmed by light microscopy of Giemsa-stained thick and thin blood films. Genomic DNA was isolated from blood spots on filter paper. Molecular characterization of P. falciparum isolates was done by allele-specific nested PCR of the highly polymorphic merozoite surface protein-2 ( msp-2 ) gene. Results Ninety-three children from 43 households were enrolled into this study. A total of 26 different msp-2 alleles were identified from 215 fragments (range: 180–480 bp). Majority of the isolates [65.6% (n = 61)] were polyclonal infections consisting of 2–6 clones and were significantly more common with the FC27 allelic family ( p = 0.036). The multiplicity of infection (MOI) per household ranged from 1.0 to 4.5 while the overall MOI in the study population was 2.31. The pattern of distribution of msp-2 allele types among the households fell into two categories: households where both msp-2 allele types (FC27 and 3D7) were present; households where only one msp-2 allele type (FC27 or 3D7) was present. Majority of the households [88.4% (n = 38)], had both msp-2 allele types but they were disproportionately distributed among the children while in a few households [11.6% (n = 5)], all the children were infected with only one type of msp-2 allele. Conclusion These findings showed that P. falciparum isolates exhibit remarkable degree of genetic diversity in the micro-environment and are composed mainly of multiclonal infections, which is an indication of a high ongoing parasite transmission. This suggests that the micro-environment is an important area of focus for malaria control interventions and for evaluating intervention programmes." @default.
• W3086238538 created "2020-09-21" @default.
• W3086238538 creator A5019776339 @default.
• W3086238538 creator A5022933310 @default.
• W3086238538 creator A5051541703 @default.
• W3086238538 creator A5051764091 @default.
• W3086238538 creator A5086597930 @default.
• W3086238538 date "2020-09-16" @default.
• W3086238538 modified "2023-10-13" @default.
• W3086238538 title "Genetic diversity and complexity of Plasmodium falciparum infections in the microenvironment among siblings of the same household in North-Central Nigeria" @default.
• W3086238538 cites W1968546203 @default.
• W3086238538 cites W1971620518 @default.
• W3086238538 cites W1980752431 @default.
• W3086238538 cites W1984891431 @default.
• W3086238538 cites W1990276564 @default.
• W3086238538 cites W1996006126 @default.
• W3086238538 cites W2002055028 @default.
• W3086238538 cites W2028626843 @default.
• W3086238538 cites W2033653481 @default.
• W3086238538 cites W2038498737 @default.
• W3086238538 cites W2043734986 @default.
• W3086238538 cites W2053169406 @default.
• W3086238538 cites W2067428749 @default.
• W3086238538 cites W2074925737 @default.
• W3086238538 cites W2074948152 @default.
• W3086238538 cites W2076340545 @default.
• W3086238538 cites W2076824514 @default.
• W3086238538 cites W2084702484 @default.
• W3086238538 cites W2094023667 @default.
• W3086238538 cites W2095554063 @default.
• W3086238538 cites W2096188314 @default.
• W3086238538 cites W2110945377 @default.
• W3086238538 cites W2121675649 @default.
• W3086238538 cites W2141788187 @default.
• W3086238538 cites W2151105515 @default.
• W3086238538 cites W2159780207 @default.
• W3086238538 cites W2344773039 @default.
• W3086238538 cites W2403300155 @default.
• W3086238538 cites W2468158669 @default.
• W3086238538 cites W2514285416 @default.
• W3086238538 cites W2606275724 @default.
• W3086238538 cites W2782495254 @default.
• W3086238538 cites W2794950859 @default.
• W3086238538 cites W2806920537 @default.
• W3086238538 cites W2898165684 @default.
• W3086238538 cites W2908798784 @default.
• W3086238538 cites W2925112039 @default.
• W3086238538 cites W2945382350 @default.
• W3086238538 cites W2947937524 @default.
• W3086238538 cites W2948328696 @default.
• W3086238538 cites W2949012927 @default.
• W3086238538 cites W2959484794 @default.
• W3086238538 cites W2978227327 @default.
• W3086238538 cites W2990904584 @default.
• W3086238538 cites W3012267867 @default.
• W3086238538 cites W3012753992 @default.
• W3086238538 cites W3021633114 @default.
• W3086238538 cites W4211010162 @default.
• W3086238538 doi "https://doi.org/10.1186/s12936-020-03415-1" @default.
• W3086238538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7493857" @default.
• W3086238538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32938438" @default.
• W3086238538 hasPublicationYear "2020" @default.
• W3086238538 type Work @default.
• W3086238538 sameAs 3086238538 @default.
• W3086238538 citedByCount "7" @default.
• W3086238538 countsByYear W30862385382022 @default.
• W3086238538 countsByYear W30862385382023 @default.
• W3086238538 crossrefType "journal-article" @default.
• W3086238538 hasAuthorship W3086238538A5019776339 @default.
• W3086238538 hasAuthorship W3086238538A5022933310 @default.
• W3086238538 hasAuthorship W3086238538A5051541703 @default.
• W3086238538 hasAuthorship W3086238538A5051764091 @default.
• W3086238538 hasAuthorship W3086238538A5086597930 @default.
• W3086238538 hasBestOaLocation W30862385381 @default.
• W3086238538 hasConcept C104317684 @default.
• W3086238538 hasConcept C159047783 @default.
• W3086238538 hasConcept C180754005 @default.
• W3086238538 hasConcept C190612196 @default.
• W3086238538 hasConcept C203014093 @default.
• W3086238538 hasConcept C203233990 @default.
• W3086238538 hasConcept C2777023991 @default.
• W3086238538 hasConcept C2778048844 @default.
• W3086238538 hasConcept C2778371730 @default.
• W3086238538 hasConcept C2781034427 @default.
• W3086238538 hasConcept C2908647359 @default.
• W3086238538 hasConcept C54355233 @default.
• W3086238538 hasConcept C71924100 @default.
• W3086238538 hasConcept C81977670 @default.
• W3086238538 hasConcept C86803240 @default.
• W3086238538 hasConcept C90856448 @default.
• W3086238538 hasConcept C99454951 @default.
• W3086238538 hasConceptScore W3086238538C104317684 @default.
• W3086238538 hasConceptScore W3086238538C159047783 @default.
• W3086238538 hasConceptScore W3086238538C180754005 @default.
• W3086238538 hasConceptScore W3086238538C190612196 @default.
• W3086238538 hasConceptScore W3086238538C203014093 @default.
• W3086238538 hasConceptScore W3086238538C203233990 @default.
• W3086238538 hasConceptScore W3086238538C2777023991 @default.
• W3086238538 hasConceptScore W3086238538C2778048844 @default.
• W3086238538 hasConceptScore W3086238538C2778371730 @default.

• next