Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086286650> ?p ?o ?g. }
- W3086286650 endingPage "6723" @default.
- W3086286650 startingPage "6723" @default.
- W3086286650 abstract "Osteolytic bone lesions are one of the central features of multiple myeloma (MM) and lead to bone pain, fractures, decreased quality of life, and decreased survival. Dysfunction of the osteoclast (OC)/osteoblast (OB) axis plays a key role in the development of myeloma-associated osteolytic lesions. Many signaling pathways and factors are associated with myeloma bone diseases (MBDs), including the RANKL/OPG and NF-κB pathways. NRF2, a master regulator of inflammatory signaling, might play a role in the regulation of bone metabolism via anti-inflammatory signaling and decreased reactive oxygen species (ROS) levels. The loss of NRF2 expression in OCs reduced bone mass via the RANK/RANKL pathway and other downstream signaling pathways that affect osteoclastogenesis. The NRF2 level in OBs could interfere with interleukin (IL)-6 expression, which is associated with bone metabolism and myeloma cells. In addition to direct impact on OCs and OBs, the activity of NRF2 on myeloma cells and mesenchymal stromal cells influences the inflammatory stress/ROS level in these cells, which has an impact on OCs, OBs, and osteocytes. The interaction between these cells and OCs affects the osteoclastogenesis of myeloma bone lesions associated with NRF2. Therefore, we have reviewed the effects of NRF2 on OCs and OBs in MBDs." @default.
- W3086286650 created "2020-09-21" @default.
- W3086286650 creator A5002356832 @default.
- W3086286650 creator A5040020654 @default.
- W3086286650 creator A5067061693 @default.
- W3086286650 creator A5072245275 @default.
- W3086286650 date "2020-09-14" @default.
- W3086286650 modified "2023-10-06" @default.
- W3086286650 title "Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2" @default.
- W3086286650 cites W124943668 @default.
- W3086286650 cites W1515922000 @default.
- W3086286650 cites W1534645474 @default.
- W3086286650 cites W1583113866 @default.
- W3086286650 cites W1594526962 @default.
- W3086286650 cites W1885204825 @default.
- W3086286650 cites W1904752902 @default.
- W3086286650 cites W1969418532 @default.
- W3086286650 cites W1970144926 @default.
- W3086286650 cites W1971720206 @default.
- W3086286650 cites W1974120192 @default.
- W3086286650 cites W1974437991 @default.
- W3086286650 cites W1975505424 @default.
- W3086286650 cites W1975953388 @default.
- W3086286650 cites W1977753585 @default.
- W3086286650 cites W1978228345 @default.
- W3086286650 cites W1982395713 @default.
- W3086286650 cites W1988210099 @default.
- W3086286650 cites W1988558619 @default.
- W3086286650 cites W1988593777 @default.
- W3086286650 cites W1991530716 @default.
- W3086286650 cites W1993511165 @default.
- W3086286650 cites W1995445783 @default.
- W3086286650 cites W1996682859 @default.
- W3086286650 cites W1997812904 @default.
- W3086286650 cites W1999043016 @default.
- W3086286650 cites W1999549312 @default.
- W3086286650 cites W1999608332 @default.
- W3086286650 cites W2002198698 @default.
- W3086286650 cites W2006371195 @default.
- W3086286650 cites W2008174509 @default.
- W3086286650 cites W2008265399 @default.
- W3086286650 cites W2008344420 @default.
- W3086286650 cites W2011772406 @default.
- W3086286650 cites W2012610632 @default.
- W3086286650 cites W2013931313 @default.
- W3086286650 cites W2018576241 @default.
- W3086286650 cites W2019582558 @default.
- W3086286650 cites W2021073309 @default.
- W3086286650 cites W2023598683 @default.
- W3086286650 cites W2025341515 @default.
- W3086286650 cites W2027352882 @default.
- W3086286650 cites W2029051823 @default.
- W3086286650 cites W2030504185 @default.
- W3086286650 cites W2033633352 @default.
- W3086286650 cites W2036368043 @default.
- W3086286650 cites W2038612772 @default.
- W3086286650 cites W2044218027 @default.
- W3086286650 cites W2045906656 @default.
- W3086286650 cites W2048299560 @default.
- W3086286650 cites W2048994674 @default.
- W3086286650 cites W2049057899 @default.
- W3086286650 cites W2050567975 @default.
- W3086286650 cites W2054531168 @default.
- W3086286650 cites W2055966182 @default.
- W3086286650 cites W2058792844 @default.
- W3086286650 cites W2061684338 @default.
- W3086286650 cites W2063048904 @default.
- W3086286650 cites W2071768625 @default.
- W3086286650 cites W2074174622 @default.
- W3086286650 cites W2076974856 @default.
- W3086286650 cites W2079168439 @default.
- W3086286650 cites W2079500084 @default.
- W3086286650 cites W2081896745 @default.
- W3086286650 cites W2082254947 @default.
- W3086286650 cites W2084776852 @default.
- W3086286650 cites W2093252878 @default.
- W3086286650 cites W2093349314 @default.
- W3086286650 cites W2093507774 @default.
- W3086286650 cites W2094961464 @default.
- W3086286650 cites W2096261918 @default.
- W3086286650 cites W2099792161 @default.
- W3086286650 cites W2102969047 @default.
- W3086286650 cites W2104976381 @default.
- W3086286650 cites W2107721348 @default.
- W3086286650 cites W2111779899 @default.
- W3086286650 cites W2112592868 @default.
- W3086286650 cites W2118394016 @default.
- W3086286650 cites W2122518329 @default.
- W3086286650 cites W2126934086 @default.
- W3086286650 cites W2128714725 @default.
- W3086286650 cites W2131862834 @default.
- W3086286650 cites W2133770419 @default.
- W3086286650 cites W2135444604 @default.
- W3086286650 cites W2135892640 @default.
- W3086286650 cites W2137667514 @default.
- W3086286650 cites W2141824025 @default.
- W3086286650 cites W2142226493 @default.
- W3086286650 cites W2142816998 @default.