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• W3086290450 abstract "Abstract Purpose To investigate the added value of gadoxetic acid-enhanced MRI in monitoring liver function and disease progression in patients with primary sclerosing cholangitis (PSC). Methods We retrospectively identified 104 consecutive patients (75 males; mean age 41.98 ± 12.5 years) with confirmed diagnosis of PSC who underwent 227 gadoxetic acid-enhanced MRI examinations between January 2008 and May 2019. Relative enhancement (RE) of the liver was correlated with the results of liver function tests (LFTs), scoring models (Model for End-Stage Liver Disease (MELD) score, Mayo Risk Score (MRS), Amsterdam-Oxford model (AOM)), and qualitative MRI findings. In addition, results were analyzed separately for excretory MRI examinations ( n = 164) and nonexcretory examinations ( n = 63) depending on excretion of gadoxetic acid into the common bile duct in the hepatobiliary phase (HBP). Results There was a significant correlation of RE with MRS ( r = − 0.652), MELD score ( r = − 0.474), AOM ( r = − 0.468), and LFTs ( P < 0.001). RE and albumin were significantly higher in the excretory group whereas scoring models, bilirubin, aspartate aminotransferase, alkaline phosphatase, and international normalized ratio were lower ( P < 0.001). RE was lower in segments with absent HBP gadoxetic acid excretion into dilated bile ducts, reduced HBP parenchymal enhancement, atrophy, T2 hyperintensity, and bile duct abnormalities ( P < 0.001). Conclusion Relative enhancement of the liver in gadoxetic acid-enhanced MRI can be used to evaluate global and regional liver function and monitor disease progression in patients with PSC. Hepatobiliary phase gadoxetic acid biliary excretion appears to be a reproducible qualitative parameter for evaluating disease severity that can be easily integrated into routine clinical practice." @default.
• W3086290450 created "2020-09-21" @default.
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• W3086290450 date "2020-09-12" @default.
• W3086290450 modified "2023-10-16" @default.
• W3086290450 title "Gadoxetic acid-enhanced MRI in primary sclerosing cholangitis: added value in assessing liver function and monitoring disease progression" @default.
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• W3086290450 doi "https://doi.org/10.1007/s00261-020-02731-z" @default.
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