FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086310236> ?p ?o ?g. }

• W3086310236 abstract "Abstract To date, the Covid-19 pandemic affected more than 18 million individuals and caused more than 690, 000 deaths. Its clinical expression is pleiomorphic and severity is related to age and comorbidities such as diabetes and hypertension. The pathophysiology of the disease relies on aberrant activation of immune system and lymphopenia that has been recognized as a prognosis marker. We wondered if the myeloid compartment was affected in Covid-19 and if monocytes and macrophages could be infected by SARS-CoV-2. We show here that SARS-CoV-2 efficiently infects monocytes and macrophages without any cytopathic effect. Infection was associated with the secretion of immunoregulatory cytokines (IL-6, IL-10, TGF-β) and the induction of a macrophagic specific transcriptional program characterized by the upregulation of M2-type molecules. In addition, we found that in vitro macrophage polarization did not account for the permissivity to SARS-CoV-2, since M1-and M2-type macrophages were similarly infected. Finally, in a cohort of 76 Covid-19 patients ranging from mild to severe clinical expression, all circulating monocyte subsets were decreased, likely related to massive emigration into tissues. Monocytes from Covid-19 patients exhibited decreased expression of HLA-DR and increased expression of CD163, irrespective of the clinical status. Hence, SARS-CoV-2 drives circulating monocytes and macrophages inducing immunoparalysis of the host for the benefit of Covid-19 disease progression." @default.
• W3086310236 created "2020-09-21" @default.
• W3086310236 creator A5022450409 @default.
• W3086310236 creator A5023619971 @default.
• W3086310236 creator A5027107191 @default.
• W3086310236 creator A5029679351 @default.
• W3086310236 creator A5034564699 @default.
• W3086310236 creator A5047868255 @default.
• W3086310236 creator A5053176793 @default.
• W3086310236 creator A5057642954 @default.
• W3086310236 creator A5059466600 @default.
• W3086310236 creator A5074730004 @default.
• W3086310236 creator A5089800716 @default.
• W3086310236 date "2020-09-17" @default.
• W3086310236 modified "2023-10-01" @default.
• W3086310236 title "Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis" @default.
• W3086310236 cites W1557119871 @default.
• W3086310236 cites W1617495083 @default.
• W3086310236 cites W1756265025 @default.
• W3086310236 cites W1759257429 @default.
• W3086310236 cites W1966929320 @default.
• W3086310236 cites W1969905647 @default.
• W3086310236 cites W1972348350 @default.
• W3086310236 cites W1994553843 @default.
• W3086310236 cites W2015222073 @default.
• W3086310236 cites W2016029872 @default.
• W3086310236 cites W2034273529 @default.
• W3086310236 cites W2123669249 @default.
• W3086310236 cites W2149784485 @default.
• W3086310236 cites W2585273079 @default.
• W3086310236 cites W2610356532 @default.
• W3086310236 cites W2626120438 @default.
• W3086310236 cites W2897945399 @default.
• W3086310236 cites W2911016491 @default.
• W3086310236 cites W2935706800 @default.
• W3086310236 cites W2941620462 @default.
• W3086310236 cites W2949235226 @default.
• W3086310236 cites W2982323076 @default.
• W3086310236 cites W3007940623 @default.
• W3086310236 cites W3009365815 @default.
• W3086310236 cites W3010198307 @default.
• W3086310236 cites W3014799733 @default.
• W3086310236 cites W3015261451 @default.
• W3086310236 cites W3016031526 @default.
• W3086310236 cites W3016288338 @default.
• W3086310236 cites W3016661132 @default.
• W3086310236 cites W3017794848 @default.
• W3086310236 cites W3018057581 @default.
• W3086310236 cites W3019031660 @default.
• W3086310236 cites W3021880084 @default.
• W3086310236 cites W3022248657 @default.
• W3086310236 cites W3023443343 @default.
• W3086310236 cites W3023982717 @default.
• W3086310236 cites W3025643075 @default.
• W3086310236 cites W3033356077 @default.
• W3086310236 cites W3041842588 @default.
• W3086310236 doi "https://doi.org/10.1101/2020.09.17.300996" @default.
• W3086310236 hasPublicationYear "2020" @default.
• W3086310236 type Work @default.
• W3086310236 sameAs 3086310236 @default.
• W3086310236 citedByCount "27" @default.
• W3086310236 countsByYear W30863102362020 @default.
• W3086310236 countsByYear W30863102362021 @default.
• W3086310236 countsByYear W30863102362022 @default.
• W3086310236 countsByYear W30863102362023 @default.
• W3086310236 crossrefType "posted-content" @default.
• W3086310236 hasAuthorship W3086310236A5022450409 @default.
• W3086310236 hasAuthorship W3086310236A5023619971 @default.
• W3086310236 hasAuthorship W3086310236A5027107191 @default.
• W3086310236 hasAuthorship W3086310236A5029679351 @default.
• W3086310236 hasAuthorship W3086310236A5034564699 @default.
• W3086310236 hasAuthorship W3086310236A5047868255 @default.
• W3086310236 hasAuthorship W3086310236A5053176793 @default.
• W3086310236 hasAuthorship W3086310236A5057642954 @default.
• W3086310236 hasAuthorship W3086310236A5059466600 @default.
• W3086310236 hasAuthorship W3086310236A5074730004 @default.
• W3086310236 hasAuthorship W3086310236A5089800716 @default.
• W3086310236 hasBestOaLocation W30863102361 @default.
• W3086310236 hasConcept C10162356 @default.
• W3086310236 hasConcept C126322002 @default.
• W3086310236 hasConcept C159047783 @default.
• W3086310236 hasConcept C202751555 @default.
• W3086310236 hasConcept C203014093 @default.
• W3086310236 hasConcept C2775858924 @default.
• W3086310236 hasConcept C2779134260 @default.
• W3086310236 hasConcept C2779244956 @default.
• W3086310236 hasConcept C2781184567 @default.
• W3086310236 hasConcept C3008058167 @default.
• W3086310236 hasConcept C524204448 @default.
• W3086310236 hasConcept C54355233 @default.
• W3086310236 hasConcept C71924100 @default.
• W3086310236 hasConcept C86803240 @default.
• W3086310236 hasConcept C8891405 @default.
• W3086310236 hasConcept C89623803 @default.
• W3086310236 hasConceptScore W3086310236C10162356 @default.
• W3086310236 hasConceptScore W3086310236C126322002 @default.
• W3086310236 hasConceptScore W3086310236C159047783 @default.
• W3086310236 hasConceptScore W3086310236C202751555 @default.
• W3086310236 hasConceptScore W3086310236C203014093 @default.
• W3086310236 hasConceptScore W3086310236C2775858924 @default.

• next