Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086498613> ?p ?o ?g. }
- W3086498613 abstract "Abstract This review article addresses the largely unanticipated convergence of two landmark discoveries. The first is the discovery of interferons, critical signaling molecules for all aspects of both innate and adaptive immunity, discovered originally by Isaacs and Lindenmann at the National Institute for Medical Research, London, in 1957 ( Proceedings of the Royal Society of London. Series B: Biological Sciences , 1957, 147 , 258). The second, formerly unrelated discovery, by Leonard Hayflick and Paul Moorhead (Wistar Institute, Philadelphia) is that cultured cells undergo an irreversible but viable growth arrest, termed senescence, after a finite and predictable number of cell divisions ( Experimental Cell Research , 1961, 25 , 585). This phenomenon was suspected to relate to organismal aging, which was confirmed subsequently ( Nature , 2011, 479 , 232). Cell senescence has broad‐ranging implications for normal homeostasis, including immunity, and for diverse disease states, including cancer progression and response to therapy ( Nature Medicine , 2015, 21, 1424; Cell , 2019, 179 , 813; Cell , 2017, 169, 1000; Trends in Cell Biology , 2018, 28 , 436; Journal of Cell Biology , 2018, 217 , 65). Here, we critically address the bidirectional interplay between interferons (focusing on type I) and cell senescence, with important implications for health and healthspan." @default.
- W3086498613 created "2020-09-21" @default.
- W3086498613 creator A5070978444 @default.
- W3086498613 creator A5085890841 @default.
- W3086498613 date "2020-09-12" @default.
- W3086498613 modified "2023-10-16" @default.
- W3086498613 title "Type I interferons and related pathways in cell senescence" @default.
- W3086498613 cites W1033197108 @default.
- W3086498613 cites W1565166977 @default.
- W3086498613 cites W1632349675 @default.
- W3086498613 cites W1681030413 @default.
- W3086498613 cites W1700369543 @default.
- W3086498613 cites W1953890763 @default.
- W3086498613 cites W1970924670 @default.
- W3086498613 cites W1974423729 @default.
- W3086498613 cites W1976273464 @default.
- W3086498613 cites W1984573053 @default.
- W3086498613 cites W1984936995 @default.
- W3086498613 cites W1991597167 @default.
- W3086498613 cites W1994826332 @default.
- W3086498613 cites W2004878760 @default.
- W3086498613 cites W2007084896 @default.
- W3086498613 cites W2010417927 @default.
- W3086498613 cites W2030467705 @default.
- W3086498613 cites W2030795773 @default.
- W3086498613 cites W2033304214 @default.
- W3086498613 cites W2041156660 @default.
- W3086498613 cites W2042716686 @default.
- W3086498613 cites W2046466087 @default.
- W3086498613 cites W2046598720 @default.
- W3086498613 cites W2054548947 @default.
- W3086498613 cites W2054995801 @default.
- W3086498613 cites W2057619489 @default.
- W3086498613 cites W2061769617 @default.
- W3086498613 cites W2064802388 @default.
- W3086498613 cites W2069611152 @default.
- W3086498613 cites W2070095332 @default.
- W3086498613 cites W2074350232 @default.
- W3086498613 cites W2080641261 @default.
- W3086498613 cites W2081796577 @default.
- W3086498613 cites W2082921795 @default.
- W3086498613 cites W2083439589 @default.
- W3086498613 cites W2092857978 @default.
- W3086498613 cites W2103324798 @default.
- W3086498613 cites W2113174452 @default.
- W3086498613 cites W2116054786 @default.
- W3086498613 cites W2119885778 @default.
- W3086498613 cites W2121371748 @default.
- W3086498613 cites W2127506701 @default.
- W3086498613 cites W2128511441 @default.
- W3086498613 cites W2131974830 @default.
- W3086498613 cites W2136744430 @default.
- W3086498613 cites W2136922347 @default.
- W3086498613 cites W2145303760 @default.
- W3086498613 cites W2153530565 @default.
- W3086498613 cites W2159591471 @default.
- W3086498613 cites W2160703969 @default.
- W3086498613 cites W2174377540 @default.
- W3086498613 cites W2176631207 @default.
- W3086498613 cites W2187414165 @default.
- W3086498613 cites W2193792657 @default.
- W3086498613 cites W2198354060 @default.
- W3086498613 cites W2261930191 @default.
- W3086498613 cites W2274643654 @default.
- W3086498613 cites W2320418617 @default.
- W3086498613 cites W2327514570 @default.
- W3086498613 cites W2341622558 @default.
- W3086498613 cites W2341631860 @default.
- W3086498613 cites W2341812625 @default.
- W3086498613 cites W2367101210 @default.
- W3086498613 cites W2558219863 @default.
- W3086498613 cites W2559263717 @default.
- W3086498613 cites W2587898769 @default.
- W3086498613 cites W2618634776 @default.
- W3086498613 cites W2620914886 @default.
- W3086498613 cites W2621003511 @default.
- W3086498613 cites W2623862783 @default.
- W3086498613 cites W2624235005 @default.
- W3086498613 cites W2727632236 @default.
- W3086498613 cites W2738136165 @default.
- W3086498613 cites W2739438570 @default.
- W3086498613 cites W2742007963 @default.
- W3086498613 cites W2745948512 @default.
- W3086498613 cites W2759661759 @default.
- W3086498613 cites W2762611634 @default.
- W3086498613 cites W2768033029 @default.
- W3086498613 cites W2772046262 @default.
- W3086498613 cites W2772147257 @default.
- W3086498613 cites W2774323335 @default.
- W3086498613 cites W2786535550 @default.
- W3086498613 cites W2788548733 @default.
- W3086498613 cites W2790220021 @default.
- W3086498613 cites W2791933562 @default.
- W3086498613 cites W2795875233 @default.
- W3086498613 cites W2798073233 @default.
- W3086498613 cites W2805184558 @default.
- W3086498613 cites W2809237949 @default.
- W3086498613 cites W2883220169 @default.
- W3086498613 cites W2887043640 @default.
- W3086498613 cites W2890087043 @default.