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- W3086544432 abstract "The novel virus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the Corona Virus Disease-2019 (COVID-19) outbreak in Wuhan, Hubei province of China. This virus disseminated rapidly and reached to an unprecedented pandemic proportion in more than 213 nations with a large number of fatalities. The hypersecretion of pro-inflammatory cytokines is the main cause of mortality and morbidity due to COVID-19, therefore strategies that avert the cytokine storm may play a crucial role in abating the severity of COVID-19. This review highlights the minute details of SARS-CoV-2, its genomic organization, genomic variations within structural and non-structural proteins and viral progression mechanism in human beings. The approaches like antiviral strategies are discussed, including drugs that obstruct viral propagation and suppress the pro-inflammatory cytokines. This compilation emphasizes Mesenchymal Stem Cells (MSCs) based therapy alone or in combination with other therapeutics as an attractive curative approach for COVID-19 pandemic. The MSCs and its secretome, including antimicrobial peptides (AMPs) have various capabilities, for instance, immunomodulation, regeneration, antimicrobial properties, potential for attenuating the cytokine storm and bare minimum chances of being infected with SARS-CoV-2 virus. The immunomodulatory property of MSCs affects inflammatory state and regulates immune response during SARS-CoV-2 infection. However, as of now, there is no WHO-approved MSCs based therapy for the treatment of COVID-19 infection. Graphical abstract." @default.
- W3086544432 created "2020-09-21" @default.
- W3086544432 creator A5004478158 @default.
- W3086544432 creator A5029992140 @default.
- W3086544432 creator A5049685887 @default.
- W3086544432 creator A5059223189 @default.
- W3086544432 creator A5060879398 @default.
- W3086544432 creator A5089315331 @default.
- W3086544432 date "2020-09-12" @default.
- W3086544432 modified "2023-09-23" @default.
- W3086544432 title "COVID-19 and its Therapeutics: Special Emphasis on Mesenchymal Stem Cells Based Therapy" @default.
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