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- W3086590811 abstract "Coenzyme Q 10 (CoQ, ubiquinone) is a redox‐active lipid endogenously synthesized by the cells. The final stage of CoQ biosynthesis is performed at the mitochondrial level by the ‘complex Q’, where coq2 is responsible for the prenylation of the benzoquinone ring of the molecule. We report that the competitive coq2 inhibitor 4‐nitrobenzoate (4‐NB) decreased the cellular CoQ content and caused severe impairment of mitochondrial function in the T67 human glioma cell line. In parallel with the reduction in CoQ biosynthesis, the cholesterol level increased, leading to significant perturbation of the plasma membrane physicochemical properties. We show that 4‐NB treatment did not significantly affect the cell viability, because of an adaptive metabolic rewiring toward glycolysis. Hypoxia‐inducible factor 1α (HIF‐1α) stabilization was detected in 4‐NB‐treated cells, possibly due to the contribution of both reduction in intracellular oxygen tension and ROS overproduction. Exogenous CoQ supplementation partially recovered cholesterol content, HIF‐1α degradation, and ROS production, whereas only weakly improved the bioenergetic impairment induced by the CoQ depletion. Our data provide new insights on the effect of CoQ depletion and contribute to shed light on the pathogenic mechanisms of ubiquinone deficiency syndrome." @default.
- W3086590811 created "2020-09-21" @default.
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- W3086590811 date "2020-09-20" @default.
- W3086590811 modified "2023-10-17" @default.
- W3086590811 title "Coenzyme Q biosynthesis inhibition induces HIF‐1α stabilization and metabolic switch toward glycolysis" @default.
- W3086590811 cites W1438668346 @default.
- W3086590811 cites W1503667331 @default.
- W3086590811 cites W1548744261 @default.
- W3086590811 cites W1582467975 @default.
- W3086590811 cites W1593974013 @default.
- W3086590811 cites W163652335 @default.
- W3086590811 cites W1701273068 @default.
- W3086590811 cites W1725920997 @default.
- W3086590811 cites W1737629705 @default.
- W3086590811 cites W1755032422 @default.
- W3086590811 cites W1775749144 @default.
- W3086590811 cites W1863866282 @default.
- W3086590811 cites W1899746275 @default.
- W3086590811 cites W1971403257 @default.
- W3086590811 cites W1971714188 @default.
- W3086590811 cites W1972651480 @default.
- W3086590811 cites W1979451357 @default.
- W3086590811 cites W1982966031 @default.
- W3086590811 cites W1988830469 @default.
- W3086590811 cites W1989089672 @default.
- W3086590811 cites W1990297217 @default.
- W3086590811 cites W1993095088 @default.
- W3086590811 cites W1995541025 @default.
- W3086590811 cites W2001293876 @default.
- W3086590811 cites W2001565942 @default.
- W3086590811 cites W2002698357 @default.
- W3086590811 cites W2007761806 @default.
- W3086590811 cites W2013911972 @default.
- W3086590811 cites W2015092837 @default.
- W3086590811 cites W2015452872 @default.
- W3086590811 cites W2016585694 @default.
- W3086590811 cites W2022396615 @default.
- W3086590811 cites W2027617372 @default.
- W3086590811 cites W2030718609 @default.
- W3086590811 cites W2031681500 @default.
- W3086590811 cites W2032720768 @default.
- W3086590811 cites W2034922793 @default.
- W3086590811 cites W2039149257 @default.
- W3086590811 cites W2039559614 @default.
- W3086590811 cites W2043805101 @default.
- W3086590811 cites W2044803485 @default.
- W3086590811 cites W2048410358 @default.
- W3086590811 cites W2053411934 @default.
- W3086590811 cites W2053839218 @default.
- W3086590811 cites W2058517050 @default.
- W3086590811 cites W2064210148 @default.
- W3086590811 cites W2065394018 @default.
- W3086590811 cites W2069204442 @default.
- W3086590811 cites W2071155009 @default.
- W3086590811 cites W2073715954 @default.
- W3086590811 cites W2074695893 @default.
- W3086590811 cites W2076936076 @default.
- W3086590811 cites W2080304715 @default.
- W3086590811 cites W2082179247 @default.
- W3086590811 cites W2083197283 @default.
- W3086590811 cites W2084124657 @default.
- W3086590811 cites W2086755952 @default.
- W3086590811 cites W2094799602 @default.
- W3086590811 cites W2097122412 @default.
- W3086590811 cites W2098972920 @default.
- W3086590811 cites W2101649001 @default.
- W3086590811 cites W2125724189 @default.
- W3086590811 cites W2132530208 @default.
- W3086590811 cites W2134579258 @default.
- W3086590811 cites W2139425600 @default.
- W3086590811 cites W2140488719 @default.
- W3086590811 cites W2141157874 @default.
- W3086590811 cites W2145640842 @default.
- W3086590811 cites W2149196660 @default.
- W3086590811 cites W2154887758 @default.
- W3086590811 cites W2164249299 @default.
- W3086590811 cites W2164332161 @default.
- W3086590811 cites W2165178639 @default.
- W3086590811 cites W2168420558 @default.
- W3086590811 cites W2203305086 @default.
- W3086590811 cites W2261478381 @default.
- W3086590811 cites W2277318350 @default.
- W3086590811 cites W2287069564 @default.