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- W3086649631 endingPage "2846" @default.
- W3086649631 startingPage "2846" @default.
- W3086649631 abstract "The aryl hydrocarbon receptor (AhR) is a nuclear protein which, upon association with certain endogenous and exogenous ligands, translocates into the nucleus, binds DNA and regulates gene expression. Tryptophan (Trp) metabolites are one of the most important endogenous AhR ligands. The intestinal microbiota is a critical player in human intestinal homeostasis. Many of its effects are mediated by an assembly of metabolites, including Trp metabolites. In the intestine, Trp is metabolized by three main routes, leading to kynurenine, serotonin, and indole derivative synthesis under the direct or indirect involvement of the microbiota. Disturbance in Trp metabolism and/or AhR activation is strongly associated with multiple gastrointestinal, neurological and metabolic disorders, suggesting Trp metabolites/AhR signaling modulation as an interesting therapeutic perspective. In this review, we describe the most recent advances concerning Trp metabolism and AhR signaling in human health and disease, with a focus on nutrition as a potential therapy to modulate Trp metabolites acting on AhR. A better understanding of the complex balance between these pathways in human health and disease will yield therapeutic opportunities." @default.
- W3086649631 created "2020-09-21" @default.
- W3086649631 creator A5008148334 @default.
- W3086649631 creator A5034315815 @default.
- W3086649631 creator A5047634766 @default.
- W3086649631 creator A5066789514 @default.
- W3086649631 creator A5069807376 @default.
- W3086649631 creator A5089682843 @default.
- W3086649631 date "2020-09-17" @default.
- W3086649631 modified "2023-10-06" @default.
- W3086649631 title "Nutritional Therapy to Modulate Tryptophan Metabolism and Aryl Hydrocarbon-Receptor Signaling Activation in Human Diseases" @default.
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