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- W3086653617 abstract "Abstract Glia play key roles in regulating multiple aspects of neuronal development and function from invertebrates to humans. We recently found microdomain Ca 2+ signaling in Drosophila cortex glia and astrocytes regulate extracellular K + buffering and neurotransmitter uptake, respectively. Here we identify a role for ER store-operated Ca 2+ entry (SOCE) in perineurial glia (PG), a distinct population that contributes to the blood-brain barrier (BBB). PG show a diverse range of Ca 2+ oscillatory activity that varies based on their locale within the brain. Unlike cortex glia and astrocytes, PG Ca 2+ oscillations do not require extracellular Ca 2+ and are blocked by inhibition of SOCE or gap junctions. Disruption of these components triggers heat shock and mechanical-induced seizure-like episodes without effecting PG morphology or large molecule BBB permeability. These findings indicate SOCE-mediated Ca 2+ oscillations in PG increase the susceptibility of seizure-like episodes in Drosophila , providing an additional link between glial Ca 2+ signaling and neuronal activity." @default.
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- W3086653617 date "2020-09-16" @default.
- W3086653617 modified "2023-09-23" @default.
- W3086653617 title "Disruption of Glial Ca2+ Oscillations at the Drosophila Blood-Brain Barrier Predisposes to Seizure-Like Behavior" @default.
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- W3086653617 doi "https://doi.org/10.1101/2020.09.16.285841" @default.
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