FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086715700> ?p ?o ?g. }

• W3086715700 abstract "Abstract Previously a small molecule SHIP inhibitor, K118, was shown to reverse high-fat diet induced obesity and improve blood glucose regulation in obese mice. K118 treatment was also found to increase the frequency and number of IL-4 producing eosinophils in the visceral fat as well as two potent immunoregulatory myeloid cell populations: M2-polarized macrophages and myeloid derived suppressor cells (MDSC) suggesting an immune regulatory mechanism. However, the cell(s) or SHIP paralog that should be targeted to improve metabolic regulation were not defined. Here we extend our understanding of how chemical inhibition of SHIP paralogs improves metabolic regulation during excess caloric intake. We compare different SHIP inhibitors in an obesity prevention model and find that selective inhibitors for SHIP1 or SHIP2 lack the ability to prevent weight gain and body fat accumulation during increased caloric intake. Surprisingly, only pan-SHIP1/2 inhibitors could prevent diet-induced obesity. We confirm that both SHIP1 and SHIP2 must be targeted by showing that dual treatment with the SHIP1 and SHIP2 selective inhibitors can reduce adiposity caused by excess caloric consumption. We also show that pan-SHIP1/2 inhibitors of two different chemical classes can control diet-induced obesity and improve blood glucose regulation. Intriguingly, we find that both classes of pan-SHIP1/2 inhibitors require an intact eosinophil compartment to prevent diet-related fat accumulation demonstrating pan-SHIP1/2 inhibitors act via the VAT innate immune compartment to control adiposity However, improved blood glucose regulation by pan-SHIP1/2 inhibition is not dependent upon eosinophils, indicating a separate mechanism of action for diet-related loss of glucose regulation." @default.
• W3086715700 created "2020-09-21" @default.
• W3086715700 creator A5002108564 @default.
• W3086715700 creator A5041837350 @default.
• W3086715700 creator A5049254716 @default.
• W3086715700 creator A5050008601 @default.
• W3086715700 creator A5052225075 @default.
• W3086715700 creator A5065803694 @default.
• W3086715700 creator A5072329883 @default.
• W3086715700 creator A5076573031 @default.
• W3086715700 creator A5085183417 @default.
• W3086715700 creator A5085697733 @default.
• W3086715700 creator A5088504256 @default.
• W3086715700 date "2020-10-15" @default.
• W3086715700 modified "2023-09-26" @default.
• W3086715700 title "Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment" @default.
• W3086715700 cites W1538313494 @default.
• W3086715700 cites W1540538922 @default.
• W3086715700 cites W1543180455 @default.
• W3086715700 cites W1936494662 @default.
• W3086715700 cites W1976255260 @default.
• W3086715700 cites W1976613325 @default.
• W3086715700 cites W1985094563 @default.
• W3086715700 cites W2002681912 @default.
• W3086715700 cites W2007079192 @default.
• W3086715700 cites W2008869160 @default.
• W3086715700 cites W2010957046 @default.
• W3086715700 cites W2018352403 @default.
• W3086715700 cites W2031163744 @default.
• W3086715700 cites W2033946555 @default.
• W3086715700 cites W2040153748 @default.
• W3086715700 cites W2060813891 @default.
• W3086715700 cites W2061048237 @default.
• W3086715700 cites W2064899968 @default.
• W3086715700 cites W2066862341 @default.
• W3086715700 cites W2074677800 @default.
• W3086715700 cites W2082263327 @default.
• W3086715700 cites W2083067420 @default.
• W3086715700 cites W2088102919 @default.
• W3086715700 cites W2088690702 @default.
• W3086715700 cites W2094558708 @default.
• W3086715700 cites W2100866502 @default.
• W3086715700 cites W2107425729 @default.
• W3086715700 cites W2125479390 @default.
• W3086715700 cites W2130874539 @default.
• W3086715700 cites W2136024338 @default.
• W3086715700 cites W2139833921 @default.
• W3086715700 cites W2142760199 @default.
• W3086715700 cites W2145697808 @default.
• W3086715700 cites W2171716580 @default.
• W3086715700 cites W2487626306 @default.
• W3086715700 cites W2529188937 @default.
• W3086715700 cites W2586853705 @default.
• W3086715700 cites W2605827566 @default.
• W3086715700 cites W2757837983 @default.
• W3086715700 cites W2760927522 @default.
• W3086715700 cites W2762158227 @default.
• W3086715700 cites W2769957434 @default.
• W3086715700 cites W2790924361 @default.
• W3086715700 cites W2802888998 @default.
• W3086715700 cites W2899219097 @default.
• W3086715700 cites W2991552355 @default.
• W3086715700 cites W3011139707 @default.
• W3086715700 cites W4205196947 @default.
• W3086715700 doi "https://doi.org/10.21203/rs.3.rs-89532/v1" @default.
• W3086715700 hasPublicationYear "2020" @default.
• W3086715700 type Work @default.
• W3086715700 sameAs 3086715700 @default.
• W3086715700 citedByCount "0" @default.
• W3086715700 crossrefType "posted-content" @default.
• W3086715700 hasAuthorship W3086715700A5002108564 @default.
• W3086715700 hasAuthorship W3086715700A5041837350 @default.
• W3086715700 hasAuthorship W3086715700A5049254716 @default.
• W3086715700 hasAuthorship W3086715700A5050008601 @default.
• W3086715700 hasAuthorship W3086715700A5052225075 @default.
• W3086715700 hasAuthorship W3086715700A5065803694 @default.
• W3086715700 hasAuthorship W3086715700A5072329883 @default.
• W3086715700 hasAuthorship W3086715700A5076573031 @default.
• W3086715700 hasAuthorship W3086715700A5085183417 @default.
• W3086715700 hasAuthorship W3086715700A5085697733 @default.
• W3086715700 hasAuthorship W3086715700A5088504256 @default.
• W3086715700 hasBestOaLocation W30867157001 @default.
• W3086715700 hasConcept C111368507 @default.
• W3086715700 hasConcept C126322002 @default.
• W3086715700 hasConcept C127313418 @default.
• W3086715700 hasConcept C134018914 @default.
• W3086715700 hasConcept C185592680 @default.
• W3086715700 hasConcept C203014093 @default.
• W3086715700 hasConcept C203635412 @default.
• W3086715700 hasConcept C2776042228 @default.
• W3086715700 hasConcept C2777037409 @default.
• W3086715700 hasConcept C2779282312 @default.
• W3086715700 hasConcept C511355011 @default.
• W3086715700 hasConcept C71924100 @default.
• W3086715700 hasConcept C86803240 @default.
• W3086715700 hasConcept C8891405 @default.
• W3086715700 hasConceptScore W3086715700C111368507 @default.
• W3086715700 hasConceptScore W3086715700C126322002 @default.
• W3086715700 hasConceptScore W3086715700C127313418 @default.
• W3086715700 hasConceptScore W3086715700C134018914 @default.

• next