Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086723583> ?p ?o ?g. }
- W3086723583 abstract "Perforin-2 (P-2) is an antimicrobial protein with unique properties to kill intracellular bacteria. Gamma delta (GD) T cells, as the major T cell population in epithelial tissues, play a central role in protective and pathogenic immune responses in the skin. However, the tissue-specific mechanisms that control the innate immune response and the effector functions of GD T cells, especially the cross-talk with commensal organisms, are not very well understood. We hypothesized that the most prevalent skin commensal microorganism, Staphylococcus epidermidis , may play a role in regulating GD T cell-mediated cutaneous responses. We analyzed antimicrobial protein P-2 expression in human skin at a single cell resolution using an amplified fluorescence in situ hybridization approach to detect P-2 mRNA in combination with immunophenotyping. We show that S. epidermidis activates GD T cells and upregulates P-2 in human skin ex vivo in a cell-specific manner. Furthermore, P-2 upregulation following S. epidermidis stimulation correlates with increased ability of skin cells to kill intracellular Staphylococcus aureus . Our findings are the first to reveal that skin commensal bacteria induce P-2 expression, which may be utilized beneficially to modulate host innate immune responses and protect from skin infections." @default.
- W3086723583 created "2020-09-21" @default.
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- W3086723583 date "2020-09-16" @default.
- W3086723583 modified "2023-10-18" @default.
- W3086723583 title "Staphylococcus epidermidis Boosts Innate Immune Response by Activation of Gamma Delta T Cells and Induction of Perforin-2 in Human Skin" @default.
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- W3086723583 doi "https://doi.org/10.3389/fimmu.2020.550946" @default.
- W3086723583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8383832" @default.
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