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- W3086775495 endingPage "173041" @default.
- W3086775495 startingPage "173041" @default.
- W3086775495 abstract "Identifying novel constituents that contribute to tobacco addiction is essential for developing more effective treatments and informing FDA regulation of tobacco products. While preclinical data indicate that monoamine oxidase (MAO) inhibitors can have abuse liability or potentiate the addiction-related effects of nicotine, most of these studies have used clinical MAO inhibitors (e.g., tranylcypromine) that are not present in cigarette smoke. The primary goal of this study was to evaluate the abuse potential of the β-carbolines harmane, norharmane, and harmine - MAO inhibitors that are found in cigarette smoke - in an intracranial self-simulation (ICSS) model in rats. A secondary goal was to evaluate the ability of norharmane to influence nicotine's acute effects on ICSS. None of the β-carbolines lowered ICSS thresholds at any dose studied when administered alone, suggesting a lack of abuse liability. Rather, all three β-carbolines produced dose-dependent elevations in ICSS thresholds, indicating aversive/anhedonic effects. Harmane and harmine also elevated ICSS response latencies, suggesting a disruption of motor function, albeit with reduced potency compared to their ICSS threshold-elevating effects. Norharmane (2.5 mg/kg) modestly attenuated the effects of nicotine on ICSS thresholds. Our findings indicate that these β-carbolines produced only aversive/anhedonic effects in an ICSS model when administered alone, and that norharmane unexpectedly attenuated nicotines acute effects on ICSS. Future work evaluating the addiction-related effects of nicotine combined with these and other MAO inhibitors present in smoke may be useful for understanding the role of MAO inhibition in tobacco addiction and informing FDA tobacco regulation." @default.
- W3086775495 created "2020-09-21" @default.
- W3086775495 creator A5015161312 @default.
- W3086775495 creator A5024499904 @default.
- W3086775495 creator A5067527382 @default.
- W3086775495 date "2020-11-01" @default.
- W3086775495 modified "2023-09-24" @default.
- W3086775495 title "β-Carbolines found in cigarette smoke elevate intracranial self-stimulation thresholds in rats" @default.
- W3086775495 cites W1032732133 @default.
- W3086775495 cites W1572047117 @default.
- W3086775495 cites W1595215265 @default.
- W3086775495 cites W1966741829 @default.
- W3086775495 cites W1971304937 @default.
- W3086775495 cites W1971492254 @default.
- W3086775495 cites W1973276415 @default.
- W3086775495 cites W1974655113 @default.
- W3086775495 cites W1975981937 @default.
- W3086775495 cites W1977919467 @default.
- W3086775495 cites W1978147611 @default.
- W3086775495 cites W1978812850 @default.
- W3086775495 cites W1981753746 @default.
- W3086775495 cites W1982164956 @default.
- W3086775495 cites W1983493680 @default.
- W3086775495 cites W1984927228 @default.
- W3086775495 cites W1988659186 @default.
- W3086775495 cites W1992555233 @default.
- W3086775495 cites W1993516763 @default.
- W3086775495 cites W1996499810 @default.
- W3086775495 cites W2000885217 @default.
- W3086775495 cites W2001283697 @default.
- W3086775495 cites W2002205150 @default.
- W3086775495 cites W2002313472 @default.
- W3086775495 cites W2002726860 @default.
- W3086775495 cites W2004361116 @default.
- W3086775495 cites W2004537227 @default.
- W3086775495 cites W2010236131 @default.
- W3086775495 cites W2010282456 @default.
- W3086775495 cites W2010558394 @default.
- W3086775495 cites W2011769360 @default.
- W3086775495 cites W2014241233 @default.
- W3086775495 cites W2015676845 @default.
- W3086775495 cites W2023504580 @default.
- W3086775495 cites W2026085537 @default.
- W3086775495 cites W2026127815 @default.
- W3086775495 cites W2028448428 @default.
- W3086775495 cites W2033802786 @default.
- W3086775495 cites W2035544445 @default.
- W3086775495 cites W2036700635 @default.
- W3086775495 cites W2041121186 @default.
- W3086775495 cites W2042853146 @default.
- W3086775495 cites W2047627020 @default.
- W3086775495 cites W2051250857 @default.
- W3086775495 cites W2054264811 @default.
- W3086775495 cites W2054422318 @default.
- W3086775495 cites W2056628198 @default.
- W3086775495 cites W2058204783 @default.
- W3086775495 cites W2059204064 @default.
- W3086775495 cites W2060712684 @default.
- W3086775495 cites W2061630301 @default.
- W3086775495 cites W2064127783 @default.
- W3086775495 cites W2067177395 @default.
- W3086775495 cites W2071249855 @default.
- W3086775495 cites W2071795608 @default.
- W3086775495 cites W2074963005 @default.
- W3086775495 cites W2075447607 @default.
- W3086775495 cites W2075847113 @default.
- W3086775495 cites W2076738154 @default.
- W3086775495 cites W2078348242 @default.
- W3086775495 cites W2086856791 @default.
- W3086775495 cites W2087896578 @default.
- W3086775495 cites W2092728570 @default.
- W3086775495 cites W2093289860 @default.
- W3086775495 cites W2095415834 @default.
- W3086775495 cites W2100734035 @default.
- W3086775495 cites W2106466862 @default.
- W3086775495 cites W2107326293 @default.
- W3086775495 cites W2115535062 @default.
- W3086775495 cites W2117878982 @default.
- W3086775495 cites W2130708245 @default.
- W3086775495 cites W2133636525 @default.
- W3086775495 cites W2134813157 @default.
- W3086775495 cites W2138349568 @default.
- W3086775495 cites W2141611982 @default.
- W3086775495 cites W2152540227 @default.
- W3086775495 cites W2153455171 @default.
- W3086775495 cites W2159609708 @default.
- W3086775495 cites W2176129006 @default.
- W3086775495 cites W2232649956 @default.
- W3086775495 cites W2315019060 @default.
- W3086775495 cites W2333088994 @default.
- W3086775495 cites W2512491620 @default.
- W3086775495 cites W2626989920 @default.
- W3086775495 cites W2752976578 @default.
- W3086775495 cites W2896740533 @default.
- W3086775495 cites W2982555156 @default.
- W3086775495 cites W3006982900 @default.
- W3086775495 cites W941693822 @default.
- W3086775495 doi "https://doi.org/10.1016/j.pbb.2020.173041" @default.