Matches in SemOpenAlex for { <https://semopenalex.org/work/W3086864070> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W3086864070 abstract "Antibacterial resistance (AR) is causing more and more bacterial infections that cannot be cured by using the antibacterial drugs that are currently available. It is predicted that 10 million people will die every year by 2050 from infections caused by antibacterial resistant strains, surpassing the predicted numbers of deaths caused by cancer. AR is therefore a global challenge and novel antibacterial strategies are in high demand. To this end, the work on exploring the pore properties of a bacterial sugar transporter, WzaK30, has led to the discovery of the first inhibitor against bacterial capsular polysaccharides export.Recently, single-molecule recapitulation of capsular polysaccharide (CPS) export and pore formation properties of Wza barrel peptides have also revealed the possibility of a next-generation of Wza strategies. These strategies are based upon the first examination and understanding of the pore properties of wild-type (WT) and mutant WzaK30 in single-molecule electrical channel recording. The initially reported experimental procedures have been further developed to enable efficient studies of other Wza homologs that are more common in bacterial pathogens causing significant bacterial infections. Therefore, this chapter presents the most recent protocols and logistics behind the research on Wza channel activity, antibacterials, and strategies. The disciplines covered here include computation, molecular biology, biochemistry, electrophysiology, microbiology, and biophysics." @default.
- W3086864070 created "2020-09-21" @default.
- W3086864070 creator A5058140959 @default.
- W3086864070 date "2020-09-13" @default.
- W3086864070 modified "2023-09-23" @default.
- W3086864070 title "Revelation of Function and Inhibition of Wza Through Single-Channel Studies" @default.
- W3086864070 cites W1992915069 @default.
- W3086864070 cites W2078611261 @default.
- W3086864070 cites W2117319600 @default.
- W3086864070 cites W2171780257 @default.
- W3086864070 cites W2268194723 @default.
- W3086864070 cites W2341503113 @default.
- W3086864070 doi "https://doi.org/10.1007/978-1-0716-0806-7_6" @default.
- W3086864070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32918730" @default.
- W3086864070 hasPublicationYear "2020" @default.
- W3086864070 type Work @default.
- W3086864070 sameAs 3086864070 @default.
- W3086864070 citedByCount "0" @default.
- W3086864070 crossrefType "book-chapter" @default.
- W3086864070 hasAuthorship W3086864070A5058140959 @default.
- W3086864070 hasConcept C104317684 @default.
- W3086864070 hasConcept C14036430 @default.
- W3086864070 hasConcept C143065580 @default.
- W3086864070 hasConcept C171250308 @default.
- W3086864070 hasConcept C185592680 @default.
- W3086864070 hasConcept C192562407 @default.
- W3086864070 hasConcept C523546767 @default.
- W3086864070 hasConcept C54355233 @default.
- W3086864070 hasConcept C547475151 @default.
- W3086864070 hasConcept C55493867 @default.
- W3086864070 hasConcept C70721500 @default.
- W3086864070 hasConcept C86803240 @default.
- W3086864070 hasConcept C89423630 @default.
- W3086864070 hasConcept C95444343 @default.
- W3086864070 hasConceptScore W3086864070C104317684 @default.
- W3086864070 hasConceptScore W3086864070C14036430 @default.
- W3086864070 hasConceptScore W3086864070C143065580 @default.
- W3086864070 hasConceptScore W3086864070C171250308 @default.
- W3086864070 hasConceptScore W3086864070C185592680 @default.
- W3086864070 hasConceptScore W3086864070C192562407 @default.
- W3086864070 hasConceptScore W3086864070C523546767 @default.
- W3086864070 hasConceptScore W3086864070C54355233 @default.
- W3086864070 hasConceptScore W3086864070C547475151 @default.
- W3086864070 hasConceptScore W3086864070C55493867 @default.
- W3086864070 hasConceptScore W3086864070C70721500 @default.
- W3086864070 hasConceptScore W3086864070C86803240 @default.
- W3086864070 hasConceptScore W3086864070C89423630 @default.
- W3086864070 hasConceptScore W3086864070C95444343 @default.
- W3086864070 hasLocation W30868640701 @default.
- W3086864070 hasOpenAccess W3086864070 @default.
- W3086864070 hasPrimaryLocation W30868640701 @default.
- W3086864070 hasRelatedWork W12562844 @default.
- W3086864070 hasRelatedWork W1501827 @default.
- W3086864070 hasRelatedWork W15924872 @default.
- W3086864070 hasRelatedWork W16773633 @default.
- W3086864070 hasRelatedWork W18048562 @default.
- W3086864070 hasRelatedWork W20845827 @default.
- W3086864070 hasRelatedWork W2416753 @default.
- W3086864070 hasRelatedWork W3413025 @default.
- W3086864070 hasRelatedWork W3982462 @default.
- W3086864070 hasRelatedWork W11830727 @default.
- W3086864070 isParatext "false" @default.
- W3086864070 isRetracted "false" @default.
- W3086864070 magId "3086864070" @default.
- W3086864070 workType "book-chapter" @default.