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• W3086914979 abstract "Dementia is a spectrum of neurological diseases characterized by memory impairment and cognitive decline with the pathogenesis and effective management remaining elusive. Several studies have identified a correlation between anemia and Alzheimer's disease and related dementias (ADRD); however, anemia subtypes and association with ADRD have yet to be studied conclusively.To study an association between ADRD and anemia of chronic inflammation.We conducted a retrospective case-control study of the patients, diagnosed with ADRD at Brookdale Hospital. Pair-wise comparisons between means of controls and cases in terms of iron studies and laboratory results were performed using a Mann-Whitney U test. Pair-wise comparisons between anemia subgroups (moderate and severe) were performed using a Two Sample proportion Z-Test, where for each couple of normally distributed population.There was a total of 4,517 (1,274 ADRD group; 3,243 Control group) patients. There was significant difference in hemoglobin 10.15 versus 11.04 [p-value <0.001]. Iron studies showed a significant difference in ferritin 395±488.18 versus 263±1023.4 [p < 0.001], total iron binding capacity 225±84.08 versus 266±82.30 [p < 0.001] and serum iron level 64±39.34 versus 53±41.83 [p < 0.001]. Folic acid and vitamin B12 levels were normal in both groups. Severe and moderate anemia in the ADRD group were respectively 6.2% [95% CI: 4.2-8.4] and 13% [95% CI: 9.8-16.2] higher. Overall, incidence of moderate-to-severe anemia was found to be 19% higher in ADRD group [95% CI: 15.8-22.1].We demonstrated an association between ADRD and anemia of chronic inflammation independent of age, renal function, and HgbA1C levels." @default.
• W3086914979 created "2020-09-21" @default.
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• W3086914979 date "2020-09-18" @default.
• W3086914979 modified "2023-10-10" @default.
• W3086914979 title "The Association Between Anemia of Chronic Inflammation and Alzheimer’s Disease and Related Dementias" @default.
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• W3086914979 doi "https://doi.org/10.3233/adr-200178" @default.
• W3086914979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7592836" @default.
• W3086914979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33163899" @default.
• W3086914979 hasPublicationYear "2020" @default.
• W3086914979 type Work @default.

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