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- W3086919235 abstract "Hyperosmolar hyperglycaemic state (HHS) has not previously been reported in cystic fibrosis-related diabetes (CFRD). We report the case of a 15-year old boy with stable CFRD who developed acute HHS after treatment with glucocorticoids and itraconazole for presumed allergic broncho-pulmonary aspergillosis (ABPA). This case highlights the dangerous and preventable combination of high glucose intake, glucocorticoids and itraconazole inhibition of CYP3A4 (with resultant glucocorticoid accumulation) that can result in a state of life- threatening HHS in an adolescent with previously stable CFRD." @default.
- W3086919235 created "2020-09-21" @default.
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- W3086919235 date "2021-03-01" @default.
- W3086919235 modified "2023-10-18" @default.
- W3086919235 title "Acute hyperosmolar hyperglycaemic state in cystic fibrosis-related diabetes caused by glucocorticoid and itraconazole interaction" @default.
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- W3086919235 doi "https://doi.org/10.1016/j.jcf.2020.08.018" @default.
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