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• W3086932903 abstract "HIV-1 is a major global health challenge. The development of an effective vaccine and/or a therapeutic cure is a top priority. The creation of vaccines that focus an antibody response toward a particular epitope of a protein has shown promise, but the genetic diversity of HIV-1 hinders this progress. Here we developed an approach using nanoengineered CD4 + T cell membrane-coated nanoparticles (TNP). Not only do TNP effectively neutralize all strains of HIV-1, but they also selectively bind to infected cells and decrease the release of HIV-1 particles through an autophagy-dependent mechanism with no drug-induced off-target or cytotoxic effects on bystander cells." @default.
• W3086932903 created "2020-09-21" @default.
• W3086932903 creator A5002540920 @default.
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• W3086932903 creator A5068365109 @default.
• W3086932903 creator A5083005519 @default.
• W3086932903 date "2020-10-27" @default.
• W3086932903 modified "2023-10-05" @default.
• W3086932903 title "CD4 ⁺ T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy" @default.
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• W3086932903 doi "https://doi.org/10.1128/mbio.00903-20" @default.
• W3086932903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7492730" @default.
• W3086932903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32934078" @default.
• W3086932903 hasPublicationYear "2020" @default.
• W3086932903 type Work @default.
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