Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087008406> ?p ?o ?g. }
- W3087008406 abstract "Abstract Background Strong evidence for a causal role of environmental factors in a congenital anomaly is still difficult to produce. The collection of statistical data is crucial for gaining a better understanding of the epidemiology and pathophysiology of these anomalies. We aimed to evaluate spatial variations in hypospadias within our region and it’s association to socioeconomic and ecological factors, taking clinical data into account. Methods All boys with hypospadias born in northern France and seen in Lille University Medical Center (Lille, France) between 1999 and 2012 were included in the analysis. We retrospectively collected geographic data, clinical data (especially known confounding factors associated with an elevated risk of hypospadias), and demographic, socio-economic and ecological data. We analyzed the entire study population and subsequently the subset of boys lacking confounding factors. Results The study sample of 975 cases of hypospadias over the 13-year period resulted in an incidence of 25.4/10,000 male births, and was characterized by significant spatial heterogeneity ( p < 0.005) and autocorrelation ( p < 0.001). We detected two high-incidence clusters that differed with regard to their land use. After the exclusion of 221 patients with confounding factors, two high-incidence clusters with significant disease risks (1.65 and 1.75, respectively; p < 0.001) and a significant difference in land use ( p < 0.001) again appeared. The first cluster contained a higher median [interquartile range] proportion of artificialized land (0.40 [0.22;0.47]) than the remaining “neutral areas” (0.19 [0.08;0.53]) did ( p < 0.001). Conversely, the second cluster contained a higher median proportion of rural land (0.90 [0.78;0.96]) than the “neutral areas” (0.81 [0.47;0.92]) did ( p < 0.001). The median deprivation index was significantly lower in the urban cluster (0.47 [0.42;0.55]) and significantly higher in the rural cluster (0.69 [0.56;0.73]) ( p < 0.001). Conclusions Our results evidenced the heterogeneous spatial distribution of cases of hypospadias in northern France. We identified two clusters with different environmental and social patterns – even after the exclusion of known confounding factors." @default.
- W3087008406 created "2020-09-25" @default.
- W3087008406 creator A5015403600 @default.
- W3087008406 creator A5020071408 @default.
- W3087008406 creator A5025735358 @default.
- W3087008406 creator A5033007484 @default.
- W3087008406 creator A5041831320 @default.
- W3087008406 creator A5071135486 @default.
- W3087008406 creator A5073197139 @default.
- W3087008406 date "2020-09-21" @default.
- W3087008406 modified "2023-10-18" @default.
- W3087008406 title "Spatial analysis of hypospadias cases in northern France: taking clinical data into account" @default.
- W3087008406 cites W1543820084 @default.
- W3087008406 cites W1785414108 @default.
- W3087008406 cites W1969861533 @default.
- W3087008406 cites W1970449109 @default.
- W3087008406 cites W1972642210 @default.
- W3087008406 cites W1974992598 @default.
- W3087008406 cites W1982747727 @default.
- W3087008406 cites W1990192504 @default.
- W3087008406 cites W1993194063 @default.
- W3087008406 cites W2002151188 @default.
- W3087008406 cites W2004014822 @default.
- W3087008406 cites W2021205852 @default.
- W3087008406 cites W2034553505 @default.
- W3087008406 cites W2039065508 @default.
- W3087008406 cites W2042240653 @default.
- W3087008406 cites W2055140432 @default.
- W3087008406 cites W2082639150 @default.
- W3087008406 cites W2091692503 @default.
- W3087008406 cites W2115351474 @default.
- W3087008406 cites W2136342893 @default.
- W3087008406 cites W2137653304 @default.
- W3087008406 cites W2143469689 @default.
- W3087008406 cites W2148619299 @default.
- W3087008406 cites W2166278496 @default.
- W3087008406 cites W2166605782 @default.
- W3087008406 cites W2166955743 @default.
- W3087008406 cites W2169862350 @default.
- W3087008406 cites W2185902525 @default.
- W3087008406 cites W2395748337 @default.
- W3087008406 cites W2410271193 @default.
- W3087008406 cites W2514671734 @default.
- W3087008406 cites W2559948664 @default.
- W3087008406 cites W2565491897 @default.
- W3087008406 cites W2596627554 @default.
- W3087008406 cites W2611218072 @default.
- W3087008406 cites W2652507990 @default.
- W3087008406 cites W2800168988 @default.
- W3087008406 cites W2885096635 @default.
- W3087008406 cites W649463998 @default.
- W3087008406 doi "https://doi.org/10.1186/s12887-020-02332-1" @default.
- W3087008406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7504625" @default.
- W3087008406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32957953" @default.
- W3087008406 hasPublicationYear "2020" @default.
- W3087008406 type Work @default.
- W3087008406 sameAs 3087008406 @default.
- W3087008406 citedByCount "1" @default.
- W3087008406 countsByYear W30870084062023 @default.
- W3087008406 crossrefType "journal-article" @default.
- W3087008406 hasAuthorship W3087008406A5015403600 @default.
- W3087008406 hasAuthorship W3087008406A5020071408 @default.
- W3087008406 hasAuthorship W3087008406A5025735358 @default.
- W3087008406 hasAuthorship W3087008406A5033007484 @default.
- W3087008406 hasAuthorship W3087008406A5041831320 @default.
- W3087008406 hasAuthorship W3087008406A5071135486 @default.
- W3087008406 hasAuthorship W3087008406A5073197139 @default.
- W3087008406 hasBestOaLocation W30870084061 @default.
- W3087008406 hasConcept C107130276 @default.
- W3087008406 hasConcept C119060515 @default.
- W3087008406 hasConcept C120665830 @default.
- W3087008406 hasConcept C121332964 @default.
- W3087008406 hasConcept C126322002 @default.
- W3087008406 hasConcept C141071460 @default.
- W3087008406 hasConcept C144024400 @default.
- W3087008406 hasConcept C149923435 @default.
- W3087008406 hasConcept C164866538 @default.
- W3087008406 hasConcept C199360897 @default.
- W3087008406 hasConcept C2777990738 @default.
- W3087008406 hasConcept C2908647359 @default.
- W3087008406 hasConcept C41008148 @default.
- W3087008406 hasConcept C61511704 @default.
- W3087008406 hasConcept C71924100 @default.
- W3087008406 hasConcept C77350462 @default.
- W3087008406 hasConcept C99454951 @default.
- W3087008406 hasConceptScore W3087008406C107130276 @default.
- W3087008406 hasConceptScore W3087008406C119060515 @default.
- W3087008406 hasConceptScore W3087008406C120665830 @default.
- W3087008406 hasConceptScore W3087008406C121332964 @default.
- W3087008406 hasConceptScore W3087008406C126322002 @default.
- W3087008406 hasConceptScore W3087008406C141071460 @default.
- W3087008406 hasConceptScore W3087008406C144024400 @default.
- W3087008406 hasConceptScore W3087008406C149923435 @default.
- W3087008406 hasConceptScore W3087008406C164866538 @default.
- W3087008406 hasConceptScore W3087008406C199360897 @default.
- W3087008406 hasConceptScore W3087008406C2777990738 @default.
- W3087008406 hasConceptScore W3087008406C2908647359 @default.
- W3087008406 hasConceptScore W3087008406C41008148 @default.
- W3087008406 hasConceptScore W3087008406C61511704 @default.
- W3087008406 hasConceptScore W3087008406C71924100 @default.