FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087009420> ?p ?o ?g. }

• W3087009420 endingPage "806" @default.
• W3087009420 startingPage "796" @default.
• W3087009420 abstract "Hyperglycemia associated with Diabetes Mellitus type 1 (DM1) comorbidity may cause severe complications in several tissues that lead to premature death. These dysfunctions are related, among others, to redox imbalances caused by the uncontrolled cellular levels of reactive oxygen species (ROS). Brain is potentially prone to develop diabetes complications because of its great susceptibility to oxidative stress. In addition to antioxidant enzymes, mitochondria-coupled hexokinase (mt-HK) plays an essential role in maintaining high flux of oxygen and glucose to control the mitochondrial membrane and redox potential in brain. This redox control is critical for healthy conditions in brain and in the pathophysiological progression of DM1. The mitochondrial and mt-HK contribution in this process is essential to understand the relationship between DM1 complications and the management of the cellular redox balance. Using a rat model of one month of hyperglycemia induced by a single administration intraperitoneally of streptozotocin, we showed in the present work that, in rat brain mitochondria, there is a specifically reduction of the mitochondrial complex I (CI) activity and an increase in the activity of the antioxidant enzyme thioredoxin reductase, which are related to decreased hydrogen peroxide generation, oxygen consumption and mt-HK coupled-to-OxPhos activity via mitochondrial CI. Surprisingly, DM1 increases respiratory parameters and mt-HK activity via mitochondrial complex II (CII). This way, for the first time, we provide evidence that early progression of hyperglycemia, in brain tissue, changes the coupling of glucose phosphorylation at the level of mitochondria by rearranging the oxidative machinery of brain mitochondria towards CII dependent electron harvest. In addition, DM1 increased the production of H2O2 by α-ketoglutarate dehydrogenase without causing oxidative stress. Finally, DM1 increased the oxidation status of PTEN and decreased the activation of NF-kB in DM1. These results indicate that this reorganization of glucose-oxygen-ROS axis in mitochondria may impact turnover of glucose, brain amino acids, redox and inflammatory signaling. In addition, this reorganization may be involved in early protection mechanisms against the development of cognitive degeneration and neurodegenerative disease, widely associated to mitochondrial CI deficits." @default.
• W3087009420 created "2020-09-25" @default.
• W3087009420 creator A5028189609 @default.
• W3087009420 creator A5028695741 @default.
• W3087009420 creator A5036302001 @default.
• W3087009420 creator A5043833292 @default.
• W3087009420 creator A5058155757 @default.
• W3087009420 creator A5066573206 @default.
• W3087009420 date "2020-11-01" @default.
• W3087009420 modified "2023-10-03" @default.
• W3087009420 title "Hyperglycemia in a type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain" @default.
• W3087009420 cites W1546592314 @default.
• W3087009420 cites W1565286226 @default.
• W3087009420 cites W1583295309 @default.
• W3087009420 cites W1610305067 @default.
• W3087009420 cites W1775749144 @default.
• W3087009420 cites W1940436875 @default.
• W3087009420 cites W1965923738 @default.
• W3087009420 cites W1966448402 @default.
• W3087009420 cites W1967133300 @default.
• W3087009420 cites W1970590967 @default.
• W3087009420 cites W1974939683 @default.
• W3087009420 cites W1978808714 @default.
• W3087009420 cites W1980573776 @default.
• W3087009420 cites W1981486828 @default.
• W3087009420 cites W1989957948 @default.
• W3087009420 cites W1993893812 @default.
• W3087009420 cites W1999620455 @default.
• W3087009420 cites W2011829284 @default.
• W3087009420 cites W2016680661 @default.
• W3087009420 cites W2031861741 @default.
• W3087009420 cites W2044437167 @default.
• W3087009420 cites W2045014938 @default.
• W3087009420 cites W2051165249 @default.
• W3087009420 cites W2065824975 @default.
• W3087009420 cites W2072985278 @default.
• W3087009420 cites W2084847422 @default.
• W3087009420 cites W2086667809 @default.
• W3087009420 cites W2090005130 @default.
• W3087009420 cites W2103861999 @default.
• W3087009420 cites W2107277218 @default.
• W3087009420 cites W2109559424 @default.
• W3087009420 cites W2122341467 @default.
• W3087009420 cites W2134295851 @default.
• W3087009420 cites W2152068171 @default.
• W3087009420 cites W2153770540 @default.
• W3087009420 cites W2278700498 @default.
• W3087009420 cites W2293679413 @default.
• W3087009420 cites W2381924987 @default.
• W3087009420 cites W2471605942 @default.
• W3087009420 cites W2509037889 @default.
• W3087009420 cites W2586992049 @default.
• W3087009420 cites W2708431081 @default.
• W3087009420 cites W2747213856 @default.
• W3087009420 cites W2767500234 @default.
• W3087009420 cites W2767608642 @default.
• W3087009420 cites W2804291526 @default.
• W3087009420 cites W2804314227 @default.
• W3087009420 cites W2811266668 @default.
• W3087009420 cites W2883601824 @default.
• W3087009420 cites W2894984077 @default.
• W3087009420 cites W2940275057 @default.
• W3087009420 cites W2997643494 @default.
• W3087009420 cites W391810772 @default.
• W3087009420 doi "https://doi.org/10.1016/j.freeradbiomed.2020.09.017" @default.
• W3087009420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32949665" @default.
• W3087009420 hasPublicationYear "2020" @default.
• W3087009420 type Work @default.
• W3087009420 sameAs 3087009420 @default.
• W3087009420 citedByCount "11" @default.
• W3087009420 countsByYear W30870094202020 @default.
• W3087009420 countsByYear W30870094202021 @default.
• W3087009420 countsByYear W30870094202022 @default.
• W3087009420 countsByYear W30870094202023 @default.
• W3087009420 crossrefType "journal-article" @default.
• W3087009420 hasAuthorship W3087009420A5028189609 @default.
• W3087009420 hasAuthorship W3087009420A5028695741 @default.
• W3087009420 hasAuthorship W3087009420A5036302001 @default.
• W3087009420 hasAuthorship W3087009420A5043833292 @default.
• W3087009420 hasAuthorship W3087009420A5058155757 @default.
• W3087009420 hasAuthorship W3087009420A5066573206 @default.
• W3087009420 hasConcept C126322002 @default.
• W3087009420 hasConcept C134018914 @default.
• W3087009420 hasConcept C185592680 @default.
• W3087009420 hasConcept C2776151105 @default.
• W3087009420 hasConcept C2777737464 @default.
• W3087009420 hasConcept C2778004101 @default.
• W3087009420 hasConcept C28859421 @default.
• W3087009420 hasConcept C3020377403 @default.
• W3087009420 hasConcept C3623737 @default.
• W3087009420 hasConcept C48349386 @default.
• W3087009420 hasConcept C55493867 @default.
• W3087009420 hasConcept C555293320 @default.
• W3087009420 hasConcept C57600042 @default.
• W3087009420 hasConcept C71924100 @default.
• W3087009420 hasConcept C86803240 @default.
• W3087009420 hasConceptScore W3087009420C126322002 @default.
• W3087009420 hasConceptScore W3087009420C134018914 @default.

• next