Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087021465> ?p ?o ?g. }
- W3087021465 abstract "ABSTRACT Most cutaneous C-fibers, including both peptidergic and non-peptidergic subtypes are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, non-peptidergic C-fibers also respond to mechanical input in the innocuous range, and so the degree to which they contribute to nociception remains unclear. To address this gap, we investigated the function of non-peptidergic afferents using the Mrgprd Cre allele. In real time place aversion studies, we found that low frequency optogenetic activation of Mrgrpd Cre lineage neurons was not aversive in naïve mice, but became aversive after spared nerve injury (SNI). To address the underlying mechanisms of this allodynia, we recorded from lamina I spinoparabrachial (SPB) neurons using the semi-intact ex vivo preparation. Following SNI, innocuous brushing of the skin gave rise to abnormal activity in lamina I SPB neurons, consisting of an increase in the proportion of recorded neurons that responded with excitatory post synaptic potentials or action potentials. This increase was likely due, at least in part, to an increase in the proportion of lamina I (LI) SPB neurons that received input upon optogenetic activation of Mrgprd Cre lineage neurons. Intriguingly, in SPB neurons there was a significant increase in the EPSC latency from Mrgprd Cre lineage input following SNI, consistent with the possibility that the greater activation post SNI could be due to the recruitment of a new polysynaptic circuit. Together, our findings suggest Mrgprd Cre lineage neurons can provide mechanical input to the dorsal horn that is non-noxious before injury but becomes noxious afterwards due the engagement of a previously silent polysynaptic circuit in the dorsal horn." @default.
- W3087021465 created "2020-09-25" @default.
- W3087021465 creator A5004387018 @default.
- W3087021465 creator A5020827217 @default.
- W3087021465 creator A5024167359 @default.
- W3087021465 creator A5031161066 @default.
- W3087021465 creator A5031620435 @default.
- W3087021465 creator A5039713783 @default.
- W3087021465 creator A5044296841 @default.
- W3087021465 creator A5054366002 @default.
- W3087021465 creator A5063073645 @default.
- W3087021465 creator A5068933185 @default.
- W3087021465 date "2020-09-19" @default.
- W3087021465 modified "2023-10-03" @default.
- W3087021465 title "Optogenetic evaluation of the ability of different cutaneous C-fiber afferents to evoke aversive behaviors" @default.
- W3087021465 cites W1544886753 @default.
- W3087021465 cites W1965018866 @default.
- W3087021465 cites W1969655931 @default.
- W3087021465 cites W1981669433 @default.
- W3087021465 cites W1984390450 @default.
- W3087021465 cites W2015347401 @default.
- W3087021465 cites W2033072655 @default.
- W3087021465 cites W2047010161 @default.
- W3087021465 cites W2047615113 @default.
- W3087021465 cites W2054024143 @default.
- W3087021465 cites W2075715972 @default.
- W3087021465 cites W2090402561 @default.
- W3087021465 cites W2099414466 @default.
- W3087021465 cites W2111631879 @default.
- W3087021465 cites W2116230226 @default.
- W3087021465 cites W2141005071 @default.
- W3087021465 cites W2166113668 @default.
- W3087021465 cites W2298396391 @default.
- W3087021465 cites W2561116469 @default.
- W3087021465 cites W2735547909 @default.
- W3087021465 cites W2757618046 @default.
- W3087021465 cites W2922942986 @default.
- W3087021465 cites W2935076193 @default.
- W3087021465 cites W2999978880 @default.
- W3087021465 cites W3016824474 @default.
- W3087021465 cites W3096332317 @default.
- W3087021465 doi "https://doi.org/10.1101/2020.09.17.296384" @default.
- W3087021465 hasPublicationYear "2020" @default.
- W3087021465 type Work @default.
- W3087021465 sameAs 3087021465 @default.
- W3087021465 citedByCount "0" @default.
- W3087021465 crossrefType "posted-content" @default.
- W3087021465 hasAuthorship W3087021465A5004387018 @default.
- W3087021465 hasAuthorship W3087021465A5020827217 @default.
- W3087021465 hasAuthorship W3087021465A5024167359 @default.
- W3087021465 hasAuthorship W3087021465A5031161066 @default.
- W3087021465 hasAuthorship W3087021465A5031620435 @default.
- W3087021465 hasAuthorship W3087021465A5039713783 @default.
- W3087021465 hasAuthorship W3087021465A5044296841 @default.
- W3087021465 hasAuthorship W3087021465A5054366002 @default.
- W3087021465 hasAuthorship W3087021465A5063073645 @default.
- W3087021465 hasAuthorship W3087021465A5068933185 @default.
- W3087021465 hasBestOaLocation W30870214651 @default.
- W3087021465 hasConcept C104211972 @default.
- W3087021465 hasConcept C105702510 @default.
- W3087021465 hasConcept C112592302 @default.
- W3087021465 hasConcept C126322002 @default.
- W3087021465 hasConcept C15490471 @default.
- W3087021465 hasConcept C169760540 @default.
- W3087021465 hasConcept C16993767 @default.
- W3087021465 hasConcept C170493617 @default.
- W3087021465 hasConcept C17077164 @default.
- W3087021465 hasConcept C172659308 @default.
- W3087021465 hasConcept C2777883359 @default.
- W3087021465 hasConcept C2779245659 @default.
- W3087021465 hasConcept C50738837 @default.
- W3087021465 hasConcept C55493867 @default.
- W3087021465 hasConcept C71924100 @default.
- W3087021465 hasConcept C86803240 @default.
- W3087021465 hasConcept C90149880 @default.
- W3087021465 hasConcept C94412978 @default.
- W3087021465 hasConceptScore W3087021465C104211972 @default.
- W3087021465 hasConceptScore W3087021465C105702510 @default.
- W3087021465 hasConceptScore W3087021465C112592302 @default.
- W3087021465 hasConceptScore W3087021465C126322002 @default.
- W3087021465 hasConceptScore W3087021465C15490471 @default.
- W3087021465 hasConceptScore W3087021465C169760540 @default.
- W3087021465 hasConceptScore W3087021465C16993767 @default.
- W3087021465 hasConceptScore W3087021465C170493617 @default.
- W3087021465 hasConceptScore W3087021465C17077164 @default.
- W3087021465 hasConceptScore W3087021465C172659308 @default.
- W3087021465 hasConceptScore W3087021465C2777883359 @default.
- W3087021465 hasConceptScore W3087021465C2779245659 @default.
- W3087021465 hasConceptScore W3087021465C50738837 @default.
- W3087021465 hasConceptScore W3087021465C55493867 @default.
- W3087021465 hasConceptScore W3087021465C71924100 @default.
- W3087021465 hasConceptScore W3087021465C86803240 @default.
- W3087021465 hasConceptScore W3087021465C90149880 @default.
- W3087021465 hasConceptScore W3087021465C94412978 @default.
- W3087021465 hasLocation W30870214651 @default.
- W3087021465 hasOpenAccess W3087021465 @default.
- W3087021465 hasPrimaryLocation W30870214651 @default.
- W3087021465 hasRelatedWork W13251716 @default.
- W3087021465 hasRelatedWork W15396697 @default.
- W3087021465 hasRelatedWork W16812718 @default.