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- W3087035133 abstract "Double‑stranded RNA‑binding protein Staufen homolog 1 (STAU1) is a highly conserved multifunctional double‑stranded RNA‑binding protein, and is a key factor in neuronal differentiation. RNA sequencing was used to analyze the overall transcriptional levels of the upregulated cells by STAU1 and control cells, and select alternative splicing (AS). It was determined that the high expression of STAU1 led to changes in the expression levels of a variety of inflammatory and immune response genes, including IFIT2, IFIT3, OASL, and CCL2. Furthermore, STAU1 was revealed to exert a significant regulatory effect on the AS of genes related to the ‘nerve growth factor receptor signaling pathway’. This is of significant importance for neuronal survival, differentiation, growth, post‑damage repair, and regeneration. In conclusion, overexpression of STAU1 was associated with immune response and regulated AS of pathways related to neuronal growth and repair. In the present study, the whole transcriptome of STAU1 expression was first analyzed, which laid a foundation for further understanding the key functions of STAU1." @default.
- W3087035133 created "2020-09-25" @default.
- W3087035133 creator A5005835095 @default.
- W3087035133 creator A5030735346 @default.
- W3087035133 creator A5040011658 @default.
- W3087035133 creator A5059649913 @default.
- W3087035133 creator A5070057735 @default.
- W3087035133 creator A5076146165 @default.
- W3087035133 date "2020-09-16" @default.
- W3087035133 modified "2023-10-05" @default.
- W3087035133 title "STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway" @default.
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