Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087050969> ?p ?o ?g. }
- W3087050969 abstract "Abstract The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) and to neoantigen-inducing translational frameshifts. Here, we develop a tool to quantify frameshift mutations in MSI colorectal and endometrial cancer. Our results show that frameshift mutation frequency is negatively correlated to the predicted immunogenicity of the resulting peptides, suggesting counterselection of cell clones with highly immunogenic frameshift peptides. This correlation is absent in tumors with Beta-2-microglobulin mutations, and HLA-A*02:01 status is related to cMS mutation patterns. Importantly, certain outlier mutations are common in MSI cancers despite being related to frameshift peptides with functionally confirmed immunogenicity, suggesting a possible driver role during MSI tumor evolution. Neoantigens resulting from shared mutations represent promising vaccine candidates for prevention of MSI cancers." @default.
- W3087050969 created "2020-09-25" @default.
- W3087050969 creator A5000002402 @default.
- W3087050969 creator A5007438121 @default.
- W3087050969 creator A5007938895 @default.
- W3087050969 creator A5010492648 @default.
- W3087050969 creator A5018260367 @default.
- W3087050969 creator A5019826590 @default.
- W3087050969 creator A5021806130 @default.
- W3087050969 creator A5024460963 @default.
- W3087050969 creator A5029575769 @default.
- W3087050969 creator A5031832059 @default.
- W3087050969 creator A5032491914 @default.
- W3087050969 creator A5037696803 @default.
- W3087050969 creator A5040995267 @default.
- W3087050969 creator A5043692337 @default.
- W3087050969 creator A5055373303 @default.
- W3087050969 creator A5058920681 @default.
- W3087050969 creator A5060068069 @default.
- W3087050969 creator A5061810062 @default.
- W3087050969 creator A5066834132 @default.
- W3087050969 creator A5068880800 @default.
- W3087050969 creator A5073082031 @default.
- W3087050969 creator A5074626747 @default.
- W3087050969 creator A5075992239 @default.
- W3087050969 creator A5077736202 @default.
- W3087050969 creator A5079885079 @default.
- W3087050969 creator A5080075021 @default.
- W3087050969 creator A5081455399 @default.
- W3087050969 creator A5087346637 @default.
- W3087050969 creator A5088415817 @default.
- W3087050969 creator A5091490797 @default.
- W3087050969 date "2020-09-21" @default.
- W3087050969 modified "2023-10-14" @default.
- W3087050969 title "The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution" @default.
- W3087050969 cites W1940241680 @default.
- W3087050969 cites W1966365850 @default.
- W3087050969 cites W1966886587 @default.
- W3087050969 cites W1970259377 @default.
- W3087050969 cites W1971706232 @default.
- W3087050969 cites W1973036934 @default.
- W3087050969 cites W1980190087 @default.
- W3087050969 cites W1988172265 @default.
- W3087050969 cites W1996145004 @default.
- W3087050969 cites W1998048927 @default.
- W3087050969 cites W2006149098 @default.
- W3087050969 cites W2009483826 @default.
- W3087050969 cites W2011301426 @default.
- W3087050969 cites W2016381774 @default.
- W3087050969 cites W2021533617 @default.
- W3087050969 cites W2030150976 @default.
- W3087050969 cites W2041146525 @default.
- W3087050969 cites W2046137036 @default.
- W3087050969 cites W2048608286 @default.
- W3087050969 cites W2051584526 @default.
- W3087050969 cites W2067366953 @default.
- W3087050969 cites W2067746546 @default.
- W3087050969 cites W2084799522 @default.
- W3087050969 cites W2085117989 @default.
- W3087050969 cites W2085289502 @default.
- W3087050969 cites W2088142339 @default.
- W3087050969 cites W2088147822 @default.
- W3087050969 cites W2089822384 @default.
- W3087050969 cites W2090109598 @default.
- W3087050969 cites W2092513068 @default.
- W3087050969 cites W2095874417 @default.
- W3087050969 cites W2109098517 @default.
- W3087050969 cites W2110863884 @default.
- W3087050969 cites W2111065592 @default.
- W3087050969 cites W2120035070 @default.
- W3087050969 cites W2142300779 @default.
- W3087050969 cites W2144612215 @default.
- W3087050969 cites W2148300747 @default.
- W3087050969 cites W2152061559 @default.
- W3087050969 cites W2154448561 @default.
- W3087050969 cites W2262414037 @default.
- W3087050969 cites W2286537003 @default.
- W3087050969 cites W2294164866 @default.
- W3087050969 cites W2294957859 @default.
- W3087050969 cites W2299919100 @default.
- W3087050969 cites W2401754931 @default.
- W3087050969 cites W2529308344 @default.
- W3087050969 cites W2552513321 @default.
- W3087050969 cites W2561088362 @default.
- W3087050969 cites W2575644545 @default.
- W3087050969 cites W2601346929 @default.
- W3087050969 cites W2604617217 @default.
- W3087050969 cites W2605738899 @default.
- W3087050969 cites W2611387862 @default.
- W3087050969 cites W2622499649 @default.
- W3087050969 cites W2625789005 @default.
- W3087050969 cites W2712302738 @default.
- W3087050969 cites W2725858612 @default.
- W3087050969 cites W2779221466 @default.
- W3087050969 cites W2790164909 @default.
- W3087050969 cites W2790528406 @default.
- W3087050969 cites W2793126529 @default.
- W3087050969 cites W2808624099 @default.
- W3087050969 cites W2890560883 @default.
- W3087050969 cites W2909679049 @default.