Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087062304> ?p ?o ?g. }
- W3087062304 endingPage "2061" @default.
- W3087062304 startingPage "2056" @default.
- W3087062304 abstract "Emerging evidence suggests that dysregulated lipid signaling is a key factor in prostate cancer (PC), through fatty acid activation of the nuclear receptors peroxisome proliferator-activated receptors (PPARs), leading to the upregulation of protumoral genes. Fatty acid-binding proteins (FABPs) are intracellular lipid-binding proteins that transport fatty acid to PPARs, facilitating their activation. FABP5 is overexpressed in PC, and correlates with poor patient prognosis and survival. Genetic knockdown or silencing of FABP5 decreases the proliferation and invasiveness of PC cells in vitro, and reduces tumor growth and metastasis in vivo. Pharmacological FABP5-specific inhibitors also reduce tumor growth and metastases, and produce synergistic effects with taxanes. In this review, we present current data supporting FABP5 as a novel molecular target for PC." @default.
- W3087062304 created "2020-09-25" @default.
- W3087062304 creator A5058542593 @default.
- W3087062304 creator A5072968238 @default.
- W3087062304 date "2020-11-01" @default.
- W3087062304 modified "2023-10-16" @default.
- W3087062304 title "FABP5 as a novel molecular target in prostate cancer" @default.
- W3087062304 cites W1830156414 @default.
- W3087062304 cites W1892151174 @default.
- W3087062304 cites W1972062117 @default.
- W3087062304 cites W1975113490 @default.
- W3087062304 cites W1982524160 @default.
- W3087062304 cites W1987120082 @default.
- W3087062304 cites W1992980803 @default.
- W3087062304 cites W1994816149 @default.
- W3087062304 cites W1996476188 @default.
- W3087062304 cites W2013276134 @default.
- W3087062304 cites W2015671992 @default.
- W3087062304 cites W2018649825 @default.
- W3087062304 cites W2041076051 @default.
- W3087062304 cites W2042916681 @default.
- W3087062304 cites W2043394879 @default.
- W3087062304 cites W2046097761 @default.
- W3087062304 cites W2066342925 @default.
- W3087062304 cites W2070909262 @default.
- W3087062304 cites W2089123258 @default.
- W3087062304 cites W2102234103 @default.
- W3087062304 cites W2122002354 @default.
- W3087062304 cites W2136423761 @default.
- W3087062304 cites W2151408193 @default.
- W3087062304 cites W2183117764 @default.
- W3087062304 cites W2265139405 @default.
- W3087062304 cites W2284196610 @default.
- W3087062304 cites W2287556702 @default.
- W3087062304 cites W2335677672 @default.
- W3087062304 cites W2414985384 @default.
- W3087062304 cites W2461732559 @default.
- W3087062304 cites W2466506392 @default.
- W3087062304 cites W2467980642 @default.
- W3087062304 cites W2471044485 @default.
- W3087062304 cites W2530030183 @default.
- W3087062304 cites W2585253307 @default.
- W3087062304 cites W2588583929 @default.
- W3087062304 cites W2594632949 @default.
- W3087062304 cites W2604985798 @default.
- W3087062304 cites W2772560157 @default.
- W3087062304 cites W2782526526 @default.
- W3087062304 cites W2791063392 @default.
- W3087062304 cites W2805508285 @default.
- W3087062304 cites W2807845979 @default.
- W3087062304 cites W2862473350 @default.
- W3087062304 cites W2883308042 @default.
- W3087062304 cites W2883943458 @default.
- W3087062304 cites W2886891214 @default.
- W3087062304 cites W2887577066 @default.
- W3087062304 cites W2905917937 @default.
- W3087062304 cites W2910249787 @default.
- W3087062304 cites W2911096837 @default.
- W3087062304 cites W2911389878 @default.
- W3087062304 cites W2944014303 @default.
- W3087062304 cites W2948389194 @default.
- W3087062304 cites W2969082564 @default.
- W3087062304 cites W2969894047 @default.
- W3087062304 cites W2981465012 @default.
- W3087062304 cites W2982336473 @default.
- W3087062304 cites W2995517824 @default.
- W3087062304 cites W2997752058 @default.
- W3087062304 cites W37959013 @default.
- W3087062304 doi "https://doi.org/10.1016/j.drudis.2020.09.018" @default.
- W3087062304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8059105" @default.
- W3087062304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32966866" @default.
- W3087062304 hasPublicationYear "2020" @default.
- W3087062304 type Work @default.
- W3087062304 sameAs 3087062304 @default.
- W3087062304 citedByCount "28" @default.
- W3087062304 countsByYear W30870623042020 @default.
- W3087062304 countsByYear W30870623042021 @default.
- W3087062304 countsByYear W30870623042022 @default.
- W3087062304 countsByYear W30870623042023 @default.
- W3087062304 crossrefType "journal-article" @default.
- W3087062304 hasAuthorship W3087062304A5058542593 @default.
- W3087062304 hasAuthorship W3087062304A5072968238 @default.
- W3087062304 hasBestOaLocation W30870623041 @default.
- W3087062304 hasConcept C104317684 @default.
- W3087062304 hasConcept C119056186 @default.
- W3087062304 hasConcept C121608353 @default.
- W3087062304 hasConcept C126322002 @default.
- W3087062304 hasConcept C127561419 @default.
- W3087062304 hasConcept C170493617 @default.
- W3087062304 hasConcept C173396325 @default.
- W3087062304 hasConcept C185592680 @default.
- W3087062304 hasConcept C187345961 @default.
- W3087062304 hasConcept C190283241 @default.
- W3087062304 hasConcept C2776834966 @default.
- W3087062304 hasConcept C2779013556 @default.
- W3087062304 hasConcept C2780192828 @default.
- W3087062304 hasConcept C502942594 @default.
- W3087062304 hasConcept C55493867 @default.