FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087082563> ?p ?o ?g. }

• W3087082563 endingPage "16" @default.
• W3087082563 startingPage "1" @default.
• W3087082563 abstract "Background . Oxaliplatin (L-OHP) resistance is a major obstacle to the effective treatment of colorectal cancer. The resistance mechanism(s) of colorectal tumors to L-OHP may be related to the regulation of ERCC1 by cancer-expressed miRNAs, but no in-depth studies on the miRNAs that affect drug resistance have been performed. Curcumin (Cur) can reverse the drug resistance of cancer cells, but its effects on ERCC1 expression and miRNA profiles in colorectal cancer have not been studied. Methods . To study the regulation effect of curcumin on ERCC1 expression and its effects on miRNAs, the L-OHP-resistant colorectal cancer cell line HCT116/L-OHP was established. MTT assays were used to evaluate cell proliferation. Flow cytometry was used to investigate apoptotic induction. Western blot and RT-PCR analysis were used to evaluate the expression of drug-associated ERCC1, Bcl-2, GST- π , MRP, P-gp, and survivin. Results . HCT116//L-OHP cell lines were successfully established. The combination of L-OHP and curcumin could reduce L-OHP resistance in vitro . In addition, combination therapy inhibited the expression of ERCC1, Bcl-2, GST- π , MRP, P-gp, and survivin at the mRNA and protein level. Curcumin was found to inhibit ERCC1 through its ability to modulate miR-409-3p. Conclusion . Curcumin can overcome L-OHP resistance in colorectal cancer cells through its effects on miR-409-3p mediated ERCC1 expression." @default.
• W3087082563 created "2020-09-25" @default.
• W3087082563 creator A5005544676 @default.
• W3087082563 creator A5029667848 @default.
• W3087082563 creator A5036157023 @default.
• W3087082563 creator A5051486275 @default.
• W3087082563 creator A5058752677 @default.
• W3087082563 creator A5073959108 @default.
• W3087082563 date "2020-09-17" @default.
• W3087082563 modified "2023-10-18" @default.
• W3087082563 title "Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p" @default.
• W3087082563 cites W1000251227 @default.
• W3087082563 cites W1853943513 @default.
• W3087082563 cites W1971460830 @default.
• W3087082563 cites W1983976206 @default.
• W3087082563 cites W2005875057 @default.
• W3087082563 cites W2028183708 @default.
• W3087082563 cites W2033431239 @default.
• W3087082563 cites W2046696501 @default.
• W3087082563 cites W2062774433 @default.
• W3087082563 cites W2084369408 @default.
• W3087082563 cites W2085955424 @default.
• W3087082563 cites W2089771474 @default.
• W3087082563 cites W2097144800 @default.
• W3087082563 cites W2131348261 @default.
• W3087082563 cites W2141116781 @default.
• W3087082563 cites W2161233842 @default.
• W3087082563 cites W2341020835 @default.
• W3087082563 cites W2439464730 @default.
• W3087082563 cites W2770729810 @default.
• W3087082563 cites W2807649309 @default.
• W3087082563 cites W2940466146 @default.
• W3087082563 cites W2946579858 @default.
• W3087082563 cites W4294112996 @default.
• W3087082563 cites W55730914 @default.
• W3087082563 doi "https://doi.org/10.1155/2020/8394574" @default.
• W3087082563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7519441" @default.
• W3087082563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33014113" @default.
• W3087082563 hasPublicationYear "2020" @default.
• W3087082563 type Work @default.
• W3087082563 sameAs 3087082563 @default.
• W3087082563 citedByCount "16" @default.
• W3087082563 countsByYear W30870825632021 @default.
• W3087082563 countsByYear W30870825632022 @default.
• W3087082563 countsByYear W30870825632023 @default.
• W3087082563 crossrefType "journal-article" @default.
• W3087082563 hasAuthorship W3087082563A5005544676 @default.
• W3087082563 hasAuthorship W3087082563A5029667848 @default.
• W3087082563 hasAuthorship W3087082563A5036157023 @default.
• W3087082563 hasAuthorship W3087082563A5051486275 @default.
• W3087082563 hasAuthorship W3087082563A5058752677 @default.
• W3087082563 hasAuthorship W3087082563A5073959108 @default.
• W3087082563 hasBestOaLocation W30870825631 @default.
• W3087082563 hasConcept C104317684 @default.
• W3087082563 hasConcept C104451858 @default.
• W3087082563 hasConcept C121608353 @default.
• W3087082563 hasConcept C126322002 @default.
• W3087082563 hasConcept C134935766 @default.
• W3087082563 hasConcept C145059251 @default.
• W3087082563 hasConcept C153911025 @default.
• W3087082563 hasConcept C190283241 @default.
• W3087082563 hasConcept C2775975398 @default.
• W3087082563 hasConcept C2778250585 @default.
• W3087082563 hasConcept C2779309665 @default.
• W3087082563 hasConcept C2780783641 @default.
• W3087082563 hasConcept C2780962732 @default.
• W3087082563 hasConcept C502942594 @default.
• W3087082563 hasConcept C526805850 @default.
• W3087082563 hasConcept C54355233 @default.
• W3087082563 hasConcept C553184892 @default.
• W3087082563 hasConcept C55493867 @default.
• W3087082563 hasConcept C71924100 @default.
• W3087082563 hasConcept C81885089 @default.
• W3087082563 hasConcept C86803240 @default.
• W3087082563 hasConcept C96232424 @default.
• W3087082563 hasConcept C98274493 @default.
• W3087082563 hasConceptScore W3087082563C104317684 @default.
• W3087082563 hasConceptScore W3087082563C104451858 @default.
• W3087082563 hasConceptScore W3087082563C121608353 @default.
• W3087082563 hasConceptScore W3087082563C126322002 @default.
• W3087082563 hasConceptScore W3087082563C134935766 @default.
• W3087082563 hasConceptScore W3087082563C145059251 @default.
• W3087082563 hasConceptScore W3087082563C153911025 @default.
• W3087082563 hasConceptScore W3087082563C190283241 @default.
• W3087082563 hasConceptScore W3087082563C2775975398 @default.
• W3087082563 hasConceptScore W3087082563C2778250585 @default.
• W3087082563 hasConceptScore W3087082563C2779309665 @default.
• W3087082563 hasConceptScore W3087082563C2780783641 @default.
• W3087082563 hasConceptScore W3087082563C2780962732 @default.
• W3087082563 hasConceptScore W3087082563C502942594 @default.
• W3087082563 hasConceptScore W3087082563C526805850 @default.
• W3087082563 hasConceptScore W3087082563C54355233 @default.
• W3087082563 hasConceptScore W3087082563C553184892 @default.
• W3087082563 hasConceptScore W3087082563C55493867 @default.
• W3087082563 hasConceptScore W3087082563C71924100 @default.
• W3087082563 hasConceptScore W3087082563C81885089 @default.
• W3087082563 hasConceptScore W3087082563C86803240 @default.
• W3087082563 hasConceptScore W3087082563C96232424 @default.

• next