Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087085627> ?p ?o ?g. }
- W3087085627 endingPage "477" @default.
- W3087085627 startingPage "465" @default.
- W3087085627 abstract "Abstract The adaptive radiations of East African cichlid fish in the Great Lakes Victoria, Malawi, and Tanganyika are well known for their diversity and repeatedly evolved phenotypes. Convergent evolution of melanic horizontal stripes has been linked to a single locus harboring the gene agouti-related peptide 2 (agrp2). However, where and when the causal variants underlying this trait evolved and how they drove phenotypic divergence remained unknown. To test the alternative hypotheses of standing genetic variation versus de novo mutations (independently originating in each radiation), we searched for shared signals of genomic divergence at the agrp2 locus. Although we discovered similar signatures of differentiation at the locus level, the haplotypes associated with stripe patterns are surprisingly different. In Lake Malawi, the highest associated alleles are located within and close to the 5′ untranslated region of agrp2 and likely evolved through recent de novo mutations. In the younger Lake Victoria radiation, stripes are associated with two intronic regions overlapping with a previously reported cis-regulatory interval. The origin of these segregating haplotypes predates the Lake Victoria radiation because they are also found in more basal riverine and Lake Kivu species. This suggests that both segregating haplotypes were present as standing genetic variation at the onset of the Lake Victoria adaptive radiation with its more than 500 species and drove phenotypic divergence within the species flock. Therefore, both new (Lake Malawi) and ancient (Lake Victoria) allelic variation at the same locus fueled rapid and convergent phenotypic evolution." @default.
- W3087085627 created "2020-09-25" @default.
- W3087085627 creator A5014141660 @default.
- W3087085627 creator A5035026759 @default.
- W3087085627 creator A5041529580 @default.
- W3087085627 creator A5086090528 @default.
- W3087085627 date "2020-09-17" @default.
- W3087085627 modified "2023-10-15" @default.
- W3087085627 title "Different Sources of Allelic Variation Drove Repeated Color Pattern Divergence in Cichlid Fishes" @default.
- W3087085627 cites W1519251643 @default.
- W3087085627 cites W1650548358 @default.
- W3087085627 cites W1963942910 @default.
- W3087085627 cites W1969042907 @default.
- W3087085627 cites W1974507358 @default.
- W3087085627 cites W1980290756 @default.
- W3087085627 cites W1992411033 @default.
- W3087085627 cites W2001632031 @default.
- W3087085627 cites W2002255114 @default.
- W3087085627 cites W2002678450 @default.
- W3087085627 cites W2006424813 @default.
- W3087085627 cites W2009439638 @default.
- W3087085627 cites W2012608894 @default.
- W3087085627 cites W2014992556 @default.
- W3087085627 cites W2021736445 @default.
- W3087085627 cites W2022366061 @default.
- W3087085627 cites W2026062398 @default.
- W3087085627 cites W2027636670 @default.
- W3087085627 cites W2038382815 @default.
- W3087085627 cites W2041292681 @default.
- W3087085627 cites W2042521784 @default.
- W3087085627 cites W2045638602 @default.
- W3087085627 cites W2046793790 @default.
- W3087085627 cites W2048619570 @default.
- W3087085627 cites W2055997230 @default.
- W3087085627 cites W2059126678 @default.
- W3087085627 cites W2061539393 @default.
- W3087085627 cites W2061634937 @default.
- W3087085627 cites W2062299199 @default.
- W3087085627 cites W2080873675 @default.
- W3087085627 cites W2093522054 @default.
- W3087085627 cites W2094026224 @default.
- W3087085627 cites W2097509699 @default.
- W3087085627 cites W2100038227 @default.
- W3087085627 cites W2100184629 @default.
- W3087085627 cites W2100481775 @default.
- W3087085627 cites W2103441770 @default.
- W3087085627 cites W2104450455 @default.
- W3087085627 cites W2106981394 @default.
- W3087085627 cites W2107006976 @default.
- W3087085627 cites W2108234281 @default.
- W3087085627 cites W2108996658 @default.
- W3087085627 cites W2111211467 @default.
- W3087085627 cites W2111647009 @default.
- W3087085627 cites W2114466140 @default.
- W3087085627 cites W2114600375 @default.
- W3087085627 cites W2122606427 @default.
- W3087085627 cites W2130071960 @default.
- W3087085627 cites W2131648469 @default.
- W3087085627 cites W2136523374 @default.
- W3087085627 cites W2138345444 @default.
- W3087085627 cites W2140056221 @default.
- W3087085627 cites W2149992227 @default.
- W3087085627 cites W2154070365 @default.
- W3087085627 cites W2154480384 @default.
- W3087085627 cites W2156352119 @default.
- W3087085627 cites W2157631711 @default.
- W3087085627 cites W2158485480 @default.
- W3087085627 cites W2160670005 @default.
- W3087085627 cites W2163604759 @default.
- W3087085627 cites W2165350687 @default.
- W3087085627 cites W2165933771 @default.
- W3087085627 cites W2167522637 @default.
- W3087085627 cites W2173518071 @default.
- W3087085627 cites W2179923542 @default.
- W3087085627 cites W2337446264 @default.
- W3087085627 cites W2432815617 @default.
- W3087085627 cites W2511632541 @default.
- W3087085627 cites W2581909912 @default.
- W3087085627 cites W2582730731 @default.
- W3087085627 cites W2587197905 @default.
- W3087085627 cites W2608168533 @default.
- W3087085627 cites W2614081736 @default.
- W3087085627 cites W2752071614 @default.
- W3087085627 cites W2792832585 @default.
- W3087085627 cites W2801361050 @default.
- W3087085627 cites W2803885453 @default.
- W3087085627 cites W2886173413 @default.
- W3087085627 cites W2886367945 @default.
- W3087085627 cites W2898275055 @default.
- W3087085627 cites W2900202053 @default.
- W3087085627 cites W2921729750 @default.
- W3087085627 cites W2944988127 @default.
- W3087085627 cites W2948867629 @default.
- W3087085627 cites W2951464304 @default.
- W3087085627 cites W2952624837 @default.
- W3087085627 cites W2970921455 @default.
- W3087085627 cites W2982348757 @default.
- W3087085627 cites W2989160997 @default.