Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087103503> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3087103503 abstract "Objective: To study the risk of generalization in patients with pure ocular MG, and specifically to assess if early treatment with steroids reduces the risk of generalized disease. Background: Ocular symptoms are often the presenting manifestations in myasthenia gravis (MG), and approximately 20% of patients have pure ocular MG. The reported risk of generalization ranges between 30 to 60%. Factors associated with increased risk of generalization include other autoimmune disease, late age of onset (> 40 years), thymus hyperplasia, and seropositive status. Early treatment with steroids may also affect rates of generalization. Design/Methods: We performed a retrospective chart review of patients with confirmed ocular MG, attending a tertiary center between 2015–2019. We included data on antibody status, age, sex, treatments, progression to generalized disease and symptom severity at the last visit. We used a Cox-proportional hazard model to assess factors associated with generalization. We will also build propensity score models to assess the effect of steroidal treatment on generalization. Results: 162 patients were included in this cohort. Mean age at onset was 57±16 years, and 78 (48%) were female. Mean follow up was 5.0±4.6 years. At the last visit, 48 (30%) of patients had generalized; mean time to generalization was 28.8 ± 41 months. The proportion of patients treated with prednisone was similar in patients who generalized vs. those who did not (65% and 61%, respectively, p=ns). The Cox model showed that age at onset was the only factor associated with generalization (HR: 3.28, CI:1.43–7.5). Conclusions: In a preliminary analysis, only older age at onset was associated with generalization; other factors did not appear to influence spread of disease. Results of the propensity score models assessing the effect of prednisone will be presented." @default.
- W3087103503 created "2020-09-25" @default.
- W3087103503 creator A5022589328 @default.
- W3087103503 creator A5043219314 @default.
- W3087103503 creator A5043897551 @default.
- W3087103503 creator A5061707941 @default.
- W3087103503 creator A5082026989 @default.
- W3087103503 creator A5084447270 @default.
- W3087103503 date "2020-04-14" @default.
- W3087103503 modified "2023-09-29" @default.
- W3087103503 title "Long-term risk of generalization in patients with pure ocular myasthenia gravis (1954)" @default.
- W3087103503 hasPublicationYear "2020" @default.
- W3087103503 type Work @default.
- W3087103503 sameAs 3087103503 @default.
- W3087103503 citedByCount "0" @default.
- W3087103503 crossrefType "journal-article" @default.
- W3087103503 hasAuthorship W3087103503A5022589328 @default.
- W3087103503 hasAuthorship W3087103503A5043219314 @default.
- W3087103503 hasAuthorship W3087103503A5043897551 @default.
- W3087103503 hasAuthorship W3087103503A5061707941 @default.
- W3087103503 hasAuthorship W3087103503A5082026989 @default.
- W3087103503 hasAuthorship W3087103503A5084447270 @default.
- W3087103503 hasConcept C126322002 @default.
- W3087103503 hasConcept C134306372 @default.
- W3087103503 hasConcept C167135981 @default.
- W3087103503 hasConcept C177148314 @default.
- W3087103503 hasConcept C187212893 @default.
- W3087103503 hasConcept C207103383 @default.
- W3087103503 hasConcept C2777960172 @default.
- W3087103503 hasConcept C2778105408 @default.
- W3087103503 hasConcept C2778720950 @default.
- W3087103503 hasConcept C33923547 @default.
- W3087103503 hasConcept C44249647 @default.
- W3087103503 hasConcept C50382708 @default.
- W3087103503 hasConcept C71924100 @default.
- W3087103503 hasConcept C72563966 @default.
- W3087103503 hasConceptScore W3087103503C126322002 @default.
- W3087103503 hasConceptScore W3087103503C134306372 @default.
- W3087103503 hasConceptScore W3087103503C167135981 @default.
- W3087103503 hasConceptScore W3087103503C177148314 @default.
- W3087103503 hasConceptScore W3087103503C187212893 @default.
- W3087103503 hasConceptScore W3087103503C207103383 @default.
- W3087103503 hasConceptScore W3087103503C2777960172 @default.
- W3087103503 hasConceptScore W3087103503C2778105408 @default.
- W3087103503 hasConceptScore W3087103503C2778720950 @default.
- W3087103503 hasConceptScore W3087103503C33923547 @default.
- W3087103503 hasConceptScore W3087103503C44249647 @default.
- W3087103503 hasConceptScore W3087103503C50382708 @default.
- W3087103503 hasConceptScore W3087103503C71924100 @default.
- W3087103503 hasConceptScore W3087103503C72563966 @default.
- W3087103503 hasLocation W30871035031 @default.
- W3087103503 hasOpenAccess W3087103503 @default.
- W3087103503 hasPrimaryLocation W30871035031 @default.
- W3087103503 hasRelatedWork W1997771109 @default.
- W3087103503 hasRelatedWork W2062088137 @default.
- W3087103503 hasRelatedWork W2066684118 @default.
- W3087103503 hasRelatedWork W2087012399 @default.
- W3087103503 hasRelatedWork W2322007335 @default.
- W3087103503 hasRelatedWork W2322743861 @default.
- W3087103503 hasRelatedWork W2354605866 @default.
- W3087103503 hasRelatedWork W2357133478 @default.
- W3087103503 hasRelatedWork W2413393947 @default.
- W3087103503 hasRelatedWork W2462780191 @default.
- W3087103503 hasRelatedWork W2745609762 @default.
- W3087103503 hasRelatedWork W2775571187 @default.
- W3087103503 hasRelatedWork W2910034320 @default.
- W3087103503 hasRelatedWork W3031908534 @default.
- W3087103503 hasRelatedWork W3121658609 @default.
- W3087103503 hasRelatedWork W3165793708 @default.
- W3087103503 hasRelatedWork W3177737735 @default.
- W3087103503 hasRelatedWork W3195005522 @default.
- W3087103503 hasRelatedWork W3212612849 @default.
- W3087103503 hasRelatedWork W40607680 @default.
- W3087103503 hasVolume "94" @default.
- W3087103503 isParatext "false" @default.
- W3087103503 isRetracted "false" @default.
- W3087103503 magId "3087103503" @default.
- W3087103503 workType "article" @default.