FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087112685> ?p ?o ?g. }

• W3087112685 endingPage "80" @default.
• W3087112685 startingPage "76" @default.
• W3087112685 abstract "•Atrial fibrillation is a common co-morbidity in bariatric surgery patients. •Anatomic changes may influence pharmacokinetic properties of anticoagulants. •Limited evidence for the use of oral anticoagulants in bariatric surgery patients. •Bariatric surgery patients were not at an increased risk for thrombosis or bleeding. •DOACs may be a reasonable alternative to warfarin in bariatric surgery patients. Anticoagulation management is challenging in bariatric surgery patients, due to altered gastrointestinal anatomy and potentially reduced absorption. Few studies have evaluated clinical outcomes in this population. The objective of this study was to compare the efficacy and safety of oral anticoagulants in patients with and without a history of bariatric surgery. A retrospective, matched cohort study was conducted, utilizing data from the OptumLabs Data Warehouse. Patients ≥18 years old, with nonvalvular atrial fibrillation (NVAF), and treated with an oral anticoagulant between January 1, 2010 and December 31, 2018 were included. Outcomes were compared between bariatric and nonbariatric surgery patients. Secondary analysis compared warfarin to the direct oral anticoagulants (DOAC) in the bariatric cohort. The primary efficacy outcome was the rate of ischemic stroke and systemic embolism and the primary safety outcome was major bleeding. A total of 1,673 bariatric surgery and 155,619 nonbariatric surgery patients were identified. There was no significant difference in the rate of ischemic stroke or systemic embolism (0.83 vs 1.32 per 100 person years; Hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.31 to 1.22; p = 0.17) or major bleeding (5.30 vs 4.87 per 100 person years; HR 1.05, 95% CI 0.80 to 1.37; p = 0.73) between bariatric and nonbariatric surgery patients. In bariatric surgery patients alone, efficacy and safety were similar with warfarin compared with the DOACs. Results of this study suggest that bariatric surgery patients are not at an increased thrombotic or bleeding risk when using oral anticoagulants for NVAF. DOACs may be a reasonable alternative to warfarin. Anticoagulation management is challenging in bariatric surgery patients, due to altered gastrointestinal anatomy and potentially reduced absorption. Few studies have evaluated clinical outcomes in this population. The objective of this study was to compare the efficacy and safety of oral anticoagulants in patients with and without a history of bariatric surgery. A retrospective, matched cohort study was conducted, utilizing data from the OptumLabs Data Warehouse. Patients ≥18 years old, with nonvalvular atrial fibrillation (NVAF), and treated with an oral anticoagulant between January 1, 2010 and December 31, 2018 were included. Outcomes were compared between bariatric and nonbariatric surgery patients. Secondary analysis compared warfarin to the direct oral anticoagulants (DOAC) in the bariatric cohort. The primary efficacy outcome was the rate of ischemic stroke and systemic embolism and the primary safety outcome was major bleeding. A total of 1,673 bariatric surgery and 155,619 nonbariatric surgery patients were identified. There was no significant difference in the rate of ischemic stroke or systemic embolism (0.83 vs 1.32 per 100 person years; Hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.31 to 1.22; p = 0.17) or major bleeding (5.30 vs 4.87 per 100 person years; HR 1.05, 95% CI 0.80 to 1.37; p = 0.73) between bariatric and nonbariatric surgery patients. In bariatric surgery patients alone, efficacy and safety were similar with warfarin compared with the DOACs. Results of this study suggest that bariatric surgery patients are not at an increased thrombotic or bleeding risk when using oral anticoagulants for NVAF. DOACs may be a reasonable alternative to warfarin." @default.
• W3087112685 created "2020-09-25" @default.
• W3087112685 creator A5008644265 @default.
• W3087112685 creator A5048391277 @default.
• W3087112685 creator A5055981968 @default.
• W3087112685 creator A5065557773 @default.
• W3087112685 creator A5071976622 @default.
• W3087112685 creator A5075933859 @default.
• W3087112685 creator A5084957131 @default.
• W3087112685 creator A5085442070 @default.
• W3087112685 date "2020-12-01" @default.
• W3087112685 modified "2023-09-24" @default.
• W3087112685 title "Safety and Efficacy of Oral Anticoagulants for Atrial Fibrillation in Patients After Bariatric Surgery" @default.
• W3087112685 cites W1974120084 @default.
• W3087112685 cites W1998939034 @default.
• W3087112685 cites W2100029868 @default.
• W3087112685 cites W2152182580 @default.
• W3087112685 cites W2560766040 @default.
• W3087112685 cites W2562676216 @default.
• W3087112685 cites W2583390449 @default.
• W3087112685 cites W2623328080 @default.
• W3087112685 cites W2663377578 @default.
• W3087112685 cites W2770462959 @default.
• W3087112685 cites W2808897013 @default.
• W3087112685 cites W2892348042 @default.
• W3087112685 cites W2912139642 @default.
• W3087112685 cites W2915948028 @default.
• W3087112685 cites W2960122264 @default.
• W3087112685 cites W2981246746 @default.
• W3087112685 cites W3000510007 @default.
• W3087112685 doi "https://doi.org/10.1016/j.amjcard.2020.09.020" @default.
• W3087112685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32941819" @default.
• W3087112685 hasPublicationYear "2020" @default.
• W3087112685 type Work @default.
• W3087112685 sameAs 3087112685 @default.
• W3087112685 citedByCount "6" @default.
• W3087112685 countsByYear W30871126852021 @default.
• W3087112685 countsByYear W30871126852022 @default.
• W3087112685 countsByYear W30871126852023 @default.
• W3087112685 crossrefType "journal-article" @default.
• W3087112685 hasAuthorship W3087112685A5008644265 @default.
• W3087112685 hasAuthorship W3087112685A5048391277 @default.
• W3087112685 hasAuthorship W3087112685A5055981968 @default.
• W3087112685 hasAuthorship W3087112685A5065557773 @default.
• W3087112685 hasAuthorship W3087112685A5071976622 @default.
• W3087112685 hasAuthorship W3087112685A5075933859 @default.
• W3087112685 hasAuthorship W3087112685A5084957131 @default.
• W3087112685 hasAuthorship W3087112685A5085442070 @default.
• W3087112685 hasConcept C126322002 @default.
• W3087112685 hasConcept C127413603 @default.
• W3087112685 hasConcept C141071460 @default.
• W3087112685 hasConcept C167135981 @default.
• W3087112685 hasConcept C207103383 @default.
• W3087112685 hasConcept C2776301958 @default.
• W3087112685 hasConcept C2778080469 @default.
• W3087112685 hasConcept C2779161974 @default.
• W3087112685 hasConcept C2780645631 @default.
• W3087112685 hasConcept C2780868729 @default.
• W3087112685 hasConcept C44249647 @default.
• W3087112685 hasConcept C71924100 @default.
• W3087112685 hasConcept C72563966 @default.
• W3087112685 hasConcept C78519656 @default.
• W3087112685 hasConceptScore W3087112685C126322002 @default.
• W3087112685 hasConceptScore W3087112685C127413603 @default.
• W3087112685 hasConceptScore W3087112685C141071460 @default.
• W3087112685 hasConceptScore W3087112685C167135981 @default.
• W3087112685 hasConceptScore W3087112685C207103383 @default.
• W3087112685 hasConceptScore W3087112685C2776301958 @default.
• W3087112685 hasConceptScore W3087112685C2778080469 @default.
• W3087112685 hasConceptScore W3087112685C2779161974 @default.
• W3087112685 hasConceptScore W3087112685C2780645631 @default.
• W3087112685 hasConceptScore W3087112685C2780868729 @default.
• W3087112685 hasConceptScore W3087112685C44249647 @default.
• W3087112685 hasConceptScore W3087112685C71924100 @default.
• W3087112685 hasConceptScore W3087112685C72563966 @default.
• W3087112685 hasConceptScore W3087112685C78519656 @default.
• W3087112685 hasLocation W30871126851 @default.
• W3087112685 hasOpenAccess W3087112685 @default.
• W3087112685 hasPrimaryLocation W30871126851 @default.
• W3087112685 hasRelatedWork W2048402298 @default.
• W3087112685 hasRelatedWork W2114223015 @default.
• W3087112685 hasRelatedWork W2157689025 @default.
• W3087112685 hasRelatedWork W2174666533 @default.
• W3087112685 hasRelatedWork W2274835053 @default.
• W3087112685 hasRelatedWork W2415605004 @default.
• W3087112685 hasRelatedWork W2460869168 @default.
• W3087112685 hasRelatedWork W2883093453 @default.
• W3087112685 hasRelatedWork W3186920255 @default.
• W3087112685 hasRelatedWork W3193900294 @default.
• W3087112685 hasVolume "136" @default.
• W3087112685 isParatext "false" @default.
• W3087112685 isRetracted "false" @default.
• W3087112685 magId "3087112685" @default.
• W3087112685 workType "article" @default.