FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087127281> ?p ?o ?g. }

• W3087127281 endingPage "184" @default.
• W3087127281 startingPage "175" @default.
• W3087127281 abstract "Research question Spontaneous pregnancy loss affects 10–15% of couples, with 1–2% suffering recurrent pregnancy loss and 50% of miscarriages remaining unexplained. Male genomic integrity is essential for healthy offspring, meaning sperm DNA quality may be important in maintaining a pregnancy. Does sperm DNA fragmentation measured by alkaline Comet assay act as a biomarker for early pregnancy loss? Design Sperm DNA fragmentation was measured by alkaline Comet test in 76 fertile donors and 217 men whose partners had recently experienced miscarriage. Couples were divided into five groups for analysis: one miscarriage after spontaneous conception; two or more miscarriages after spontaneous conception; one miscarriage after fertility treatment; two or more miscarriages after fertility treatment and biochemical pregnancy. Results Receiver operator characteristic curve analysis was used to determine ability of the average Comet score (ACS), low Comet score (LCS) and high Comet score (HCS) to diagnose miscarriage and develop clinical thresholds comparing men whose partners have miscarried with men with recently proven fertility. Male partners of women who had miscarried had higher sperm DNA damage (ACS 33.32 ± 0.57%) than fertile men (ACS 14.87 ± 0.66%; P < 0.001). Average Comet score, HCS and LCS all have promise as being highly predictive of sporadic and recurrent miscarriage using clinical thresholds from comparisons with fertile men's spermatozoa: receiver operating characteristic curve AUC for ACS ≥26%, 0.965; LCS ≤70%, 0.969; HCS ≥2%, 0.883; P <0.0001. Conclusions Sperm DNA damage measured by the alkaline Comet has promise as a robust biomarker for sporadic and recurrent miscarriage after spontaneous or assisted conception, and may provide novel diagnoses and guidance for future fertility pathways." @default.
• W3087127281 created "2020-09-25" @default.
• W3087127281 creator A5004968201 @default.
• W3087127281 creator A5016754055 @default.
• W3087127281 creator A5029370774 @default.
• W3087127281 creator A5071595215 @default.
• W3087127281 creator A5073744040 @default.
• W3087127281 creator A5074418395 @default.
• W3087127281 date "2021-01-01" @default.
• W3087127281 modified "2023-10-18" @default.
• W3087127281 title "Sperm DNA fragmentation is a novel biomarker for early pregnancy loss" @default.
• W3087127281 cites W127380927 @default.
• W3087127281 cites W1799018209 @default.
• W3087127281 cites W1997128871 @default.
• W3087127281 cites W2002278578 @default.
• W3087127281 cites W2006450021 @default.
• W3087127281 cites W2020156123 @default.
• W3087127281 cites W2031534477 @default.
• W3087127281 cites W2053810364 @default.
• W3087127281 cites W2054476512 @default.
• W3087127281 cites W2054736526 @default.
• W3087127281 cites W2063337177 @default.
• W3087127281 cites W2063544723 @default.
• W3087127281 cites W2068706047 @default.
• W3087127281 cites W2069267204 @default.
• W3087127281 cites W2070097578 @default.
• W3087127281 cites W2073408492 @default.
• W3087127281 cites W2101568640 @default.
• W3087127281 cites W2101675918 @default.
• W3087127281 cites W2101705104 @default.
• W3087127281 cites W2106575294 @default.
• W3087127281 cites W2110983499 @default.
• W3087127281 cites W2112144902 @default.
• W3087127281 cites W2121918908 @default.
• W3087127281 cites W2133060396 @default.
• W3087127281 cites W2138519096 @default.
• W3087127281 cites W2141565053 @default.
• W3087127281 cites W2148711201 @default.
• W3087127281 cites W2156652088 @default.
• W3087127281 cites W2170091198 @default.
• W3087127281 cites W2513054984 @default.
• W3087127281 cites W2537067372 @default.
• W3087127281 cites W2550134727 @default.
• W3087127281 cites W2569134268 @default.
• W3087127281 cites W2753654420 @default.
• W3087127281 cites W2805117239 @default.
• W3087127281 cites W2890387926 @default.
• W3087127281 cites W2893048482 @default.
• W3087127281 cites W2906851243 @default.
• W3087127281 doi "https://doi.org/10.1016/j.rbmo.2020.09.016" @default.
• W3087127281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33082108" @default.
• W3087127281 hasPublicationYear "2021" @default.
• W3087127281 type Work @default.
• W3087127281 sameAs 3087127281 @default.
• W3087127281 citedByCount "19" @default.
• W3087127281 countsByYear W30871272812020 @default.
• W3087127281 countsByYear W30871272812021 @default.
• W3087127281 countsByYear W30871272812022 @default.
• W3087127281 countsByYear W30871272812023 @default.
• W3087127281 crossrefType "journal-article" @default.
• W3087127281 hasAuthorship W3087127281A5004968201 @default.
• W3087127281 hasAuthorship W3087127281A5016754055 @default.
• W3087127281 hasAuthorship W3087127281A5029370774 @default.
• W3087127281 hasAuthorship W3087127281A5071595215 @default.
• W3087127281 hasAuthorship W3087127281A5073744040 @default.
• W3087127281 hasAuthorship W3087127281A5074418395 @default.
• W3087127281 hasConcept C131872663 @default.
• W3087127281 hasConcept C143425029 @default.
• W3087127281 hasConcept C16685009 @default.
• W3087127281 hasConcept C190283241 @default.
• W3087127281 hasConcept C2777688143 @default.
• W3087127281 hasConcept C2779234561 @default.
• W3087127281 hasConcept C2779245376 @default.
• W3087127281 hasConcept C2780358455 @default.
• W3087127281 hasConcept C2781087480 @default.
• W3087127281 hasConcept C2781197716 @default.
• W3087127281 hasConcept C2908647359 @default.
• W3087127281 hasConcept C29456083 @default.
• W3087127281 hasConcept C31573885 @default.
• W3087127281 hasConcept C43759708 @default.
• W3087127281 hasConcept C518429986 @default.
• W3087127281 hasConcept C54355233 @default.
• W3087127281 hasConcept C552990157 @default.
• W3087127281 hasConcept C71924100 @default.
• W3087127281 hasConcept C86803240 @default.
• W3087127281 hasConcept C99454951 @default.
• W3087127281 hasConceptScore W3087127281C131872663 @default.
• W3087127281 hasConceptScore W3087127281C143425029 @default.
• W3087127281 hasConceptScore W3087127281C16685009 @default.
• W3087127281 hasConceptScore W3087127281C190283241 @default.
• W3087127281 hasConceptScore W3087127281C2777688143 @default.
• W3087127281 hasConceptScore W3087127281C2779234561 @default.
• W3087127281 hasConceptScore W3087127281C2779245376 @default.
• W3087127281 hasConceptScore W3087127281C2780358455 @default.
• W3087127281 hasConceptScore W3087127281C2781087480 @default.
• W3087127281 hasConceptScore W3087127281C2781197716 @default.
• W3087127281 hasConceptScore W3087127281C2908647359 @default.
• W3087127281 hasConceptScore W3087127281C29456083 @default.

• next