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- W3087130358 abstract "We report the structural, photophysical, and photobiological properties of a promising BODIPY-anthracene dyad (BAD) that was previously shown to induce a therapeutic effect against MDA-MB-468 cells. The BODIPY was synthesized and its crystal structure was elucidated. We further investigate the potential of this molecule as a versatile photosensitizer for photodynamic therapy against AY27 and F98 cancer cell models. Both necrosis and apoptosis were found to play a role in cell death and G1 phase arrestation was observed following PDT. From time-resolved spectroscopic analysis of absorbance and luminescence, it was found that the singlet oxygen quantum yield of the most promising BODIPY-anthracene dyad is high (>70 %) and originates from a triplet state. Interestingly, despite the efficient PDT effect, long-lived triplet states or singlet oxygen formation were not observed when water (or D2O) was used as the solvent but were readily observed in solvents such as MeOH and EtOH." @default.
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- W3087130358 date "2020-10-14" @default.
- W3087130358 modified "2023-10-01" @default.
- W3087130358 title "Structural, Photophysical, and Photobiological Studies on BODIPY‐Anthracene Dyads" @default.
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- W3087130358 doi "https://doi.org/10.1002/cptc.202000191" @default.
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