FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087130409> ?p ?o ?g. }

• W3087130409 abstract "Abstract The anterior nucleus of the thalamus (ANT) mediates cortical-subcortical interactions between the limbic system and is hypothesized to facilitate the early organization of temporal lobe seizures. We set out to investigate the dynamic changes in synchronization parameters between the seizure onset zone (SOZ) and ANT during seizure stages (pre-onset to post-termination) in seven patients (n=26 seizures) with drug-resistant nonlesional temporal lobe epilepsy. Using local field potentials recorded directly from the limbic system and the ANT during stereoelectroencephalography, we confirm that the onset of mesial temporal lobe seizure is associated with increased thalamocortical network excitability and phase-amplitude coupling. The increase in thalamocortical phase synchronization preceded seizure onset, thereby suggesting that the early organization of temporal lobe seizures involves the integration of the ANT within the epileptic network. Towards seizure termination, there is a significant decrease in thalamic excitability, thalamocortical synchronization, and decoupling, thereby suggesting a breakdown in thalamocortical connectivity. A higher disease burden is significantly correlated with increased synchronization between the ANT and epileptic networks. Collectively, the results elucidate mechanistic insights and provide the temporal architecture of thalamocortical interactions that can be targeted in the rational designing of closed-loop seizure abortive interventions. Highlights Anterior nucleus of thalamus is coactivated at the onset of temporal lobe seizures Increase thalamocortical synchronization and excitability is observed at seizure onset Seizure termination is characterized by a breakdown in thalamocortical connectivity Increased seizure burden affects thalamocortical synchronization" @default.
• W3087130409 created "2020-09-25" @default.
• W3087130409 creator A5015941553 @default.
• W3087130409 creator A5031326006 @default.
• W3087130409 creator A5061065548 @default.
• W3087130409 creator A5073509572 @default.
• W3087130409 creator A5083783525 @default.
• W3087130409 creator A5090556983 @default.
• W3087130409 date "2020-09-19" @default.
• W3087130409 modified "2023-10-09" @default.
• W3087130409 title "Anterior Nucleus of Thalamus Gates Progression of Mesial Temporal Seizures by Modulating Thalamocortical Synchrony" @default.
• W3087130409 cites W1449283962 @default.
• W3087130409 cites W1503935526 @default.
• W3087130409 cites W1521617359 @default.
• W3087130409 cites W1527468221 @default.
• W3087130409 cites W1698604584 @default.
• W3087130409 cites W1967939721 @default.
• W3087130409 cites W1968962031 @default.
• W3087130409 cites W1971828356 @default.
• W3087130409 cites W1972328487 @default.
• W3087130409 cites W1972496509 @default.
• W3087130409 cites W1973275441 @default.
• W3087130409 cites W1978389345 @default.
• W3087130409 cites W1986533481 @default.
• W3087130409 cites W1987906186 @default.
• W3087130409 cites W1994058708 @default.
• W3087130409 cites W1995096582 @default.
• W3087130409 cites W1996338330 @default.
• W3087130409 cites W2004703759 @default.
• W3087130409 cites W2008953662 @default.
• W3087130409 cites W2009546211 @default.
• W3087130409 cites W2012630986 @default.
• W3087130409 cites W2025933288 @default.
• W3087130409 cites W2045747994 @default.
• W3087130409 cites W2052644075 @default.
• W3087130409 cites W2059015493 @default.
• W3087130409 cites W2062559281 @default.
• W3087130409 cites W2069157127 @default.
• W3087130409 cites W2072309637 @default.
• W3087130409 cites W2073428061 @default.
• W3087130409 cites W2081523440 @default.
• W3087130409 cites W2084395790 @default.
• W3087130409 cites W2091028315 @default.
• W3087130409 cites W2095143979 @default.
• W3087130409 cites W2106822551 @default.
• W3087130409 cites W2109582949 @default.
• W3087130409 cites W2126012718 @default.
• W3087130409 cites W2128404682 @default.
• W3087130409 cites W2130243088 @default.
• W3087130409 cites W2136812849 @default.
• W3087130409 cites W2137231621 @default.
• W3087130409 cites W2143776609 @default.
• W3087130409 cites W2150041178 @default.
• W3087130409 cites W2154557769 @default.
• W3087130409 cites W2156108573 @default.
• W3087130409 cites W2158334924 @default.
• W3087130409 cites W2163877249 @default.
• W3087130409 cites W2169705862 @default.
• W3087130409 cites W2177232575 @default.
• W3087130409 cites W2256201004 @default.
• W3087130409 cites W2474562303 @default.
• W3087130409 cites W2524560745 @default.
• W3087130409 cites W2593164275 @default.
• W3087130409 cites W2594644573 @default.
• W3087130409 cites W2615983117 @default.
• W3087130409 cites W2765627740 @default.
• W3087130409 cites W2775243036 @default.
• W3087130409 cites W2781296888 @default.
• W3087130409 cites W2805368395 @default.
• W3087130409 cites W2871023201 @default.
• W3087130409 cites W2883027749 @default.
• W3087130409 cites W2883869440 @default.
• W3087130409 cites W2893791175 @default.
• W3087130409 cites W2909200296 @default.
• W3087130409 cites W2920961427 @default.
• W3087130409 cites W2949606941 @default.
• W3087130409 cites W2950023299 @default.
• W3087130409 cites W2950038320 @default.
• W3087130409 cites W2971082874 @default.
• W3087130409 cites W2978635590 @default.
• W3087130409 cites W2982499269 @default.
• W3087130409 cites W3014375247 @default.
• W3087130409 cites W3015184661 @default.
• W3087130409 cites W4232944527 @default.
• W3087130409 doi "https://doi.org/10.1101/2020.09.17.301812" @default.
• W3087130409 hasPublicationYear "2020" @default.
• W3087130409 type Work @default.
• W3087130409 sameAs 3087130409 @default.
• W3087130409 citedByCount "2" @default.
• W3087130409 countsByYear W30871304092022 @default.
• W3087130409 countsByYear W30871304092023 @default.
• W3087130409 crossrefType "posted-content" @default.
• W3087130409 hasAuthorship W3087130409A5015941553 @default.
• W3087130409 hasAuthorship W3087130409A5031326006 @default.
• W3087130409 hasAuthorship W3087130409A5061065548 @default.
• W3087130409 hasAuthorship W3087130409A5073509572 @default.
• W3087130409 hasAuthorship W3087130409A5083783525 @default.
• W3087130409 hasAuthorship W3087130409A5090556983 @default.
• W3087130409 hasBestOaLocation W30871304091 @default.
• W3087130409 hasConcept C15744967 @default.

• next