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- W3087152883 abstract "Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Irrespective of the underlying profibrotic condition (e.g. ageing, diabetes, hypertension), maladaptive cardiac fibrosis is defined by the transformation of resident fibroblasts to matrix-secreting myofibroblasts. Numerous profibrotic factors have been identified at the molecular level (e.g. TGFβ, IL11, AngII), which activate gene expression programs for myofibroblast activation. A number of existing HF therapies indirectly target fibrotic pathways; however, despite multiple clinical trials in HFpEF, a specific clinically effective antifibrotic therapy remains elusive. Therapeutic inhibition of TGFβ, the master-regulator of fibrosis, has unfortunately proven toxic and ineffective in clinical trials to date, and new approaches are needed. In this review, we discuss the pathophysiology and clinical implications of interstitial fibrosis in HFpEF. We provide an overview of trials targeting fibrosis in HFpEF to date and discuss the promise of potential new therapeutic approaches and targets in the context of underlying molecular mechanisms." @default.
- W3087152883 created "2020-09-25" @default.
- W3087152883 creator A5000353690 @default.
- W3087152883 creator A5071216592 @default.
- W3087152883 creator A5078655163 @default.
- W3087152883 date "2020-09-21" @default.
- W3087152883 modified "2023-10-14" @default.
- W3087152883 title "Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?" @default.
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