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- W3087165503 endingPage "1516" @default.
- W3087165503 startingPage "1496" @default.
- W3087165503 abstract "As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer." @default.
- W3087165503 created "2020-09-25" @default.
- W3087165503 creator A5027424742 @default.
- W3087165503 creator A5071568171 @default.
- W3087165503 creator A5077849607 @default.
- W3087165503 creator A5090885441 @default.
- W3087165503 date "2020-09-01" @default.
- W3087165503 modified "2023-10-14" @default.
- W3087165503 title "Glutamine reliance in cell metabolism" @default.
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